CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology

Journal of NeuroVirology

Volumn 7, Issue 5, 2001, Pages 409-420

  Begolka, W S ^a   Haynes, L M ^a   Olson, J K ^a   Padilla, J ^a   Neville, K L ^a   Dal Canto, M ^a   Palma, J ^a   Kim, B S ^a   Miller, S D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

2 microglobulin; CD8; Demyelination; Multiple sclerosis; Theiler's virus

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; MYELIN; PROTEOLIPID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM INFECTION; CHRONIC DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DEMYELINATING DISEASE; DISEASE COURSE; DISEASE PREDISPOSITION; DISEASE RESISTANCE; FEMALE; HISTOPATHOLOGY; IN VITRO STUDY; INCIDENCE; INFLAMMATORY INFILTRATE; LEG; MACROPHAGE; MONONUCLEAR CELL; MOUSE; MOUSE STRAIN; MURINE ENCEPHALOMYELITIS VIRUS; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTECTION; SPASTIC PARESIS; SPINAL CORD; T LYMPHOCYTE SUBPOPULATION; VIRUS INFECTION; VIRUS LOAD;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD8; ANTIGENS, VIRAL; BETA 2-MICROGLOBULIN; BRAIN; CAPSID; CAPSID PROTEINS; CARDIOVIRUS INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DEMYELINATING DISEASES; EPITOPES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HYPERSENSITIVITY, DELAYED; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MYELIN PROTEOLIPID PROTEIN; OVALBUMIN; PEPTIDE FRAGMENTS; RNA, MESSENGER; SPINAL CORD; THEILOVIRUS;

ANIMALIA; MURINAE; THEILER VIRUS; THEILER'S ENCEPHALOMYELITIS VIRUS;

EID: 0034754761     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/135502801753170264     Document Type: Article

References (52)

1. Differential expression of inflammatory cytokines parallels progression of central nervous system pathology in two clinically distinct models of multiple sclerosis
2. + T cells contribute to protection in Theiler's murine encephalomyelitis
3. Type 1 and type 2: A functional dichotomy for all T cell subsets
4. Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: Correlation with clinical signs
5. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: Correlation with TMEV-specific delayed-type hypersensitivity
6. Generation of polarized antigen-specific CD8 effector populations: Reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles
7. An early, abundant cytotoxic T-lymphocyte response against Theiler's virus is critical for preventing viral persistence
8. Theiler's virus infection of β2-microglobulin-deficient mice
9. Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: Critical importance of timing of treatment
10. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an specific for an immunodominant VP2 epitope
11. Theiler's virus in brain cell cultures: Lysis of neurons and oligodendrocytes and persistence in astrocytes and macrophages
12. + T cells
13. Suppressive effect on Theiler's murine encephalomyelitis virus-induced demyelinating disease by the administration of anti-IL-12 antibody
14. Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease
15. Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction
16. + T cells
17. Epidemiologic evidence for multiple sclerosis as an infection
18. In vivo administration of interleukin-2 protects susceptible mice from Theiler's virus persistence
19. Cellular reservoirs for coronavirus infection of the brain in β2-microglobulin knockout mice
20. CD8 Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions
21. VP1 and VP2 capsid proteins of Theiler's virus are targets of H-2D-restricted cytotoxic lymphocytes in the central nervous system of B10 mice
22. Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus
23. Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus
24. Central nervous system immunity in mice infected with Theiler's virus. I. Local neutralizing antibody response
25. Theiler's virus antigen detected in mouse spinal cord 21/2 years after infection
26. + cytotoxic T-cell responses during chronic viral infection
27. The immunopathogenesis and regulation of T-cell mediated demyelinating diseases
28. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
29. + T cells make discrete contributions to demyelination and neurologic disease in a viral model of multiple sclerosis
30. + lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice
31. Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice
32. Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures
33. Theiler's virus infection induces a specific cytotoxic T lymphocyte response
34. Theiler's virus infection of perforin-deficient mice
35. Split tolerance of Th1 and Th2 cells in tolerance to Theiler's murine encephalomyelitis virus
36. + T cell-mediated pathology
37. Class I-deficient resistant mice intracerebrally inoculated with Theiler's virus show an increased T cell response to viral antigens and susceptibility to demyelination
38. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis
39. Demyelination induced by Theiler's virus: Influence of the H-2 haplotype
40. b mice deficient in β2-microglobulin
41. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens)
42. Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region
43. Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis
44. Theiler's virus-associated antigens on the surfaces of cultured glial cells
45. Successful therapy of Theiler's virus-induced demyelination (DA Strain) with monoclonal anti-Lyt-2 antibody
46. + T cells secreting Th1 or Th2 cytokines
47. + TC1 cells: Loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and of other cytokines
48. + T helper type 2 cells
49. Multiple sclerosis: More genes versus environment
50. The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice
51. Role of individual T-cell epitopes of Theiler's virus in the pathogenesis of demyelination correlates with the ability to induce a Th1 response
52. + cytolytic T cells