Cellular sources and targets of IFN-γ-mediated protection against viral demyelination and neurological deficits

European Journal of Immunology

Volumn 32, Issue 3, 2002, Pages 606-615

  Murray, Paul D ^a   McGavern, Dorian B ^a   Pease, Larry R ^a   Rodriguez, Moses ^a  

^a MAYO CLINIC   (United States)

Author keywords

Glia; Multiple sclerosis; Neuroimmunology; Oligodendrocyte; T cell

Indexed keywords

ALPHA INTERFERON RECEPTOR; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BONE MARROW; CENTRAL NERVOUS SYSTEM; CHIMERA; CONTROLLED STUDY; DEMYELINATION; GENE DISRUPTION; GLIA; GLIA CELL; HEMATOPOIETIC CELL; HOST RESISTANCE; INTERFERON PRODUCTION; MOUSE; MULTIPLE SCLEROSIS; MURINE ENCEPHALOMYELITIS VIRUS; NATURAL KILLER CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SOMATIC CELL; T LYMPHOCYTE; TARGET CELL; VIRUS INFECTION;

ANIMALS; ANTIGENS, VIRAL; BONE MARROW TRANSPLANTATION; CARDIOVIRUS INFECTIONS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CROSSES, GENETIC; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; IMMUNOTHERAPY, ADOPTIVE; INTERFERON TYPE II; LYMPHOCYTE SUBSETS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; PSYCHOMOTOR PERFORMANCE; RADIATION CHIMERA; RECEPTORS, INTERFERON; RNA, VIRAL; SPINAL CORD; THEILOVIRUS;

EID: 0036210434     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200203)32:3<606::AID-IMMU606>3.0.CO;2-D     Document Type: Article

References (40)

1. Lymphokine-activated killer cells, natural killer cells and cytokines
2. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
3. + T cells secreting Th1 or Th2 cytokines
4. Cellular responses to interferon-gamma
5. Molecular basis of interferon-gamma and lipopolysaccharide enhancement of phagocyte respiratory burst capability. Studies on the gene expression of several NADPH oxidase components
6. New insights into the regulation of inducible nitric oxide synthesis
7. Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development
8. A direct role for IFN-gamma in regulation of Th1 cell development
9. Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
10. Germline transcripts of the murine immunoglobulin g2a gene: Structure and induction by interferon-gamma
11. Interferon-induced dsRNA-activated protein kinase (PKR): Antiproliferative, antiviral and antitumoral functions
12. The role of gamma interferon in immune resistance to vaginal infection by herpes simplex virus type 2 in mice
13. Exacerbated viral hepatitis in IFN-gamma receptor-deficient mice is not suppressed by IL-12
14. Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice
15. Interferon-gamma: The major mediator of resistance against Toxoplasma gondii
16. The regulation of immunity to Leishmania major
17. Immune response in mice that lack the interferon-gamma receptor
18. The IFN-gamma receptor: A paradigm for cytokine receptor signaling
19. Persistent infection of a glioma cell line generates a Theiler's virus variant which fails to induce demyelinating disease in SJL/J mice
20. CD4(+) and CD8(+) T cells make discrete contributions to demyelination and neurological disease in a viral model of multiple sclerosis
21. Spontaneous CNS remyelination in beta(2) microglobulin-deficient mice following virus-induced demyelination
22. Absence of neurological deficits following extensive demyelination in a class I-deficient murine model of multiple sclerosis
23. Theiler's virus infection of beta 2-microglobulin-deficient mice
24. Theiler's virus persistence and demyelination in major histocompatibility complex class II-deficient mice
25. Infection of class II-deficient mice by the DA strain of Theiler's virus
26. Gamma interferon is critical for resistance to Theiler's virus-induced demyelination
27. Alteration in the level of interferon-gamma results in acceleration of Theiler's virus-induced demyelinating disease
28. Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors
29. Quantitative assessment of neurological deficits in a chronic progressive murine model of CNS demyelination
30. Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
31. Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus
32. The immune system preferentially clears Theiler's virus from the gray matter of the central nervous system
33. + T cell response
34. Effector cells of both nonhemopoietic and hemopoietic origin are required for interferon (IFN)-gamma-and tumor necrosis factor (TNF)-alpha-dependent host resistance to the intracellular pathogen, Toxoplasma gondii
35. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes
36. + and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: Requirements for IL-2
37. Prevalent class I-restricted T cell response to the Theiler's virus epitope D-b: VP2(121-130) in the absence of endogenous CD4 help, tumor necrosis factor alpha, gamma interferon, perforin, or costimulation through CD28
38. Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis
39. Demyelinative myelopathy in mice induced by the DA virus
40. The balance between persistent virus infection and immune cells determines demyelination