Expression of ionotropic glutamate receptor GLUR3 and effects of glutamate on MBP- and MOG-specific lymphocyte activation and chemotactic migration in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 188, Issue 1-2, 2007, Pages 146-158

  Sarchielli, Paola ^a   Di Filippo, Massimiliano ^a   Candeliere, Antonio ^a   Chiasserini, Davide ^a   Mattioni, Alessia ^a   Tenaglia, Serena ^a   Bonucci, Michele ^a   Calabresi, Paolo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

AMPA receptor GluR3; Chemotactic migration; CXCL12 stromal cell derived factor 1; Disease activity; MBP; MIP 1 ; MOG; Multiple sclerosis; RANTES; T lymphocytes, proliferative response

Indexed keywords

AMPA RECEPTOR; GADOLINIUM PENTETATE; GLUTAMATE RECEPTOR 3; GLUTAMIC ACID; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; RANTES; STROMAL CELL DERIVED FACTOR 1;

ADULT; ARTICLE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID LEVEL; CHEMOTAXIS; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); DISEASE ACTIVITY; EXTRACELLULAR SPACE; FEMALE; HUMAN; IMMUNOBLOTTING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE MIGRATION; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECEPTOR UPREGULATION; RELAPSE; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ADULT; CASE-CONTROL STUDIES; CELL MOVEMENT; CHEMOKINES, CXC; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HUMANS; LYMPHOCYTES; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; MYELIN-ASSOCIATED GLYCOPROTEIN; RANTES; RECEPTORS, AMPA;

EID: 34447627677     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.05.021     Document Type: Article

References (48)

1. Bannert N., Craig S., Farzan M., Sogah D., Santo N.V., Choe H., and Sodroski J. Sialylated O-glycans and sulfated tyrosines in the NH2-terminal domain of CC chemokine receptor 5 contribute to high affinity binding of chemokines. J. Exp. Med. 194 (2001) 1661-1673
2. Baribaud F., Edwards T.G., Sharron M., Brelot A., Heveker N., Price K., Mortari F., Alizon M., Tsang M., and Doms R.W. Antigenically distinct conformations of CXCR4. J. Virol. 75 (2001) 8957-8967
3. Boldyrev A.A., Carpenter D.O., and Johnson P. Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems. J. Neurochem. 95 (2005) 913-918
4. Boven L.A., Montagne L., Nottet H.S., and De Groot C.J. Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesions. Clin. Exp. Immunol. 122 (2000) 257-263
5. Boyum A. A one-stage procedure for isolation of granulocytes and lymphocytes from human blood. General sedimentation properties of white blood cells in a 1 g gravity field. Scand. J. Clin. Lab. Invest., Suppl. 97 (1968) 51-76
6. Butt A.M. Neurotransmitter-mediated calcium signalling in oligodendrocyte physiology and pathology. Glia 54 (2006) 666-675
7. Butt A.M., Hamilton N., Hubbard P., Pugh M., and Ibrahim M. Synantocytes: the fifth element. J. Anat. 207 (2005) 695-706
8. Droge W., Eck H.P., Betzler M., Schlag P., Drings P., and Ebert W. Plasma glutamate concentration and lymphocyte activity. J. Cancer Res. Clin. Oncol. 114 (1988) 124-128
9. Ganor Y., Besser M., Ben-Zakay N., Unger T., and Levite M. Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration. J. Immunol. 170 (2003) 4362-4372
10. Ganor Y., Teichberg V.I., and Levite M. TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine/paracrine granzyme B-mediated proteolytic cleavage. J. Immunol. 178 (2007) 683-692
11. Groom A.J., Smith T., and Turski L. Multiple sclerosis and glutamate. Ann. N. Y. Acad. Sci. 993 (2003) 229-275
12. Gupta S., Fernandes G., Nair M., and Good R.A. Spontaneous and antibody-dependent cell-mediated cytotoxicity by human T cell subpopulations. Proc. Natl. Acad. Sci. U. S. A. 75 (1978) 5137-5141
13. Jalonen T.O., Pulkkinen K., Ukkonen M., Saarela M., and Elovaara I. Differential intracellular expression of CCR5 and chemokines in multiple sclerosis subtypes. J. Neurol. 249 (2002) 576-583
14. James G., and Butt A.M. P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 447 (2002) 247-260
15. Kanwar J.R. Anti-inflammatory immunotherapy for multiple sclerosis/experimental autoimmune encephalomyelitis (EAE) disease. Curr. Med. Chem. 12 (2005) 2947-2962
16. Kanwar J.R., Kanwar R.K., and Krissansen G.W. Simultaneous neuroprotection and blockade of inflammation reverses autoimmune encephalomyelitis. Brain 127 (2004) 1313-1331
17. Karadottir R., Cavelier P., Bergersen L.H., and Attwell D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 438 (2005) 1162-1166
18. Kay H.D., Bonnard G.D., West W.H., and Herberman R.B. A functional comparison of human Fc-receptor-bearing lymphocytes active in natural cytotoxicity and antibody-dependent cellular cytotoxicity. J. Immunol. 118 (1977) 2058-2066
19. Kostanyan I.A., Navolotskaya E.V., and Nurieva R.I. Identification of binding sites for l-glutamate on T lymphocytes. Russ. J. Immunol. 2 (1997) 135-137
20. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33 (1983) 1444-1452
21. Levite M. Nerve-driven immunity. The direct effects of neurotransmitters on T-cell function. Ann. N. Y. Acad. Sci. 917 (2000) 307-321
22. Levite M. Nervous immunity: neurotransmitters, extracellular K+ and T-cell function. Trends Immunol. 22 (2001) 2-5
23. Levite M., and Chowers Y. Nerve-driven immunity: neuropeptides regulate cytokine secretion of T cells and intestinal epithelial cells in a direct, powerful and contextual manner. Ann. Oncol. 12 (2001) S19-S25
24. Li S., Mealing G.A., Morley P., and Stys P.K. Novel injury mechanism in anoxia and trauma of spinal cord white matter: glutamate release via reverse Na+-dependent glutamate transport. J. Neurosci. 19 (1999) RC16, 1-9
25. Lombardi G., Miglio G., Canonico P.L., Naldi P., Comi C., and Monaco F. Abnormal response to glutamate of T lymphocytes from multiple sclerosis patients. Neurosci. Lett. 340 (2003) 5-8
26. Lombardi G., Miglio G., Dianzani C., Mesturini R., Varsaldi F., Chiocchetti A., Dianzani U., and Fantozzi R. Glutamate modulation of human lymphocyte growth: in vitro studies. Biochem. Biophys. Res. Commun. 318 (2004) 496-502
27. Lublin F.D., and Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46 (1996) 907-911
28. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noort S., Weinshenker B.Y., and Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 50 (2001) 121-127
29. Miglio G., Varsaldi F., Dianzani C., Fantozzi R., and Lombardi G. Stimulation of group I metabotropic glutamate receptors evokes calcium signals and c-jun and c-fos gene expression in human T cells. Biochem. Pharmacol. 70 (2005) 189-199
30. Miller D.H., Grossman R.I., Reingold S.C., and McFarland H.F. The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 121 (1998) 3-24
31. Neuhaus O., Farina C., Yassouridis A., Wiendl H., Then Bergh F., Dose T., Wekerle H., and Hohlfeld R. Multiple sclerosis: comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 7452-7457
32. Nguyen D.H., and Taub D. CXCR4 function requires membrane cholesterol: implications for HIV infection. J. Immunol. 168 (2002) 4121-4126
33. Nitsch R., Pohlm E.E., Smorodchenko A., Infante-Duarte C., Aktas O., and Zipp F. Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J. Neurosci. 24 (2004) 2458-2464
34. Pacheco R., Ciruela F., Casado V., Mallol J., Gallart T., Lluis C., and Franco R. Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation. J. Biol. Chem. 279 (2004) 33352-33358
35. Petit I., Szyper-Kravitz M., Nagler A., Lahav M., Peled A., Habler L., Ponomaryov T., Taichman R.S., Arenzana-Seisdedos F., Fujii N., Sandbank J., Zipori D., and Lapidot T. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 3 (2002) 687-694
36. Pitt D., Werner P., and Raine C.S. Glutamate excitototoxicity in a model of multiple sclerosis. Nat. Med. 6 (2000) 67-70
37. Qiu Y., Peng Y., and Wang J. Immunoregulatory role of neurotransmitters. Adv. Neuroimmunol. 6 (1996) 223-231
38. Sarchielli P., Greco L., Floridi A., Floridi A., and Gallai V. Excitatory amino acids and multiple sclerosis: evidence from cerebrospinal fluid. Arch. Neurol. 60 (2003) 1082-1088
39. Smith T., Groom A., Zhu B., and Turski L. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat. Med. 6 (2000) 62-66
40. Srinivasan R., Sailasuta N., Hurd R., Nelson S., and Pelletier D. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 128 (2005) 1016-1025
41. Stoll G., Jander S., and Schroeter M. Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system. Adv. Exp. Med. Biol. 513 (2002) 87-113
42. Stys P.K. General mechanisms of axonal damage and its prevention. J. Neurol. Sci. 233 (2005) 3-13
43. Tejada-Simon M.V., Zang Y.C., Yang D., Hong J., Li S., Singh R.A., Van den Berg-Loonen E., Killian J.M., Rivera V.M., and Zhang J.Z. Aberrant T cell responses to myelin antigens during clinical exacerbation in patients with multiple sclerosis. Int. Immunol. 12 (2000) 1641-1650
44. Vallejo-Illarramendi A., Domercq M., Perez-Cerda F., Ravid R., and Matute C. Increased expression and function of glutamate transporters in multiple sclerosis. Neurobiol. Dis. 21 (2006) 154-164
45. Werner P., Pitt D., and Raine C.S. Glutamate excitotoxicity-a mechanism for axonal damage and oligodendrocyte death in multiple sclerosis?. J. Neural Transm. Suppl. 60 (2000) 375-385
46. Werner P., Pitt D., and Raine C.S. Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage. Ann. Neurol. 50 (2001) 169-180
47. Wosik K., Ruffini F., Almazan G., Olivier A., Nalbantoglu J., and Antel J.P. Resistance of human adult oligodendrocytes to AMPA/kainate receptor-mediated glutamate injury. Brain 127 (2004) 2636-2648
48. Zang Y.C., Samanta A.K., Halder J.B., Hong J., Tejada-Simon M.V., Rivera V.M., and Zhang J.Z. Aberrant T cell migration toward RANTES and MIP-1 alpha in patients with multiple sclerosis. Overexpression of chemokine receptor CCR5. Brain 123 (2000) 1874-1882