The subpopulation of CF-1 mice deficient in P-glycoprotein contains a murine retroviral insertion in the mdr1a gene

Journal of Biochemical and Molecular Toxicology

Volumn 15, Issue 2, 2001, Pages 83-89

  Pippert, Todd R ^a   Umbenhauer, Diane R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CF 1 mouse; Multidrug resistance; P glycoprotein

Indexed keywords

ANTIPARASITIC AGENT; AVERMECTIN; DNA; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN LEVEL; CLINICAL PROTOCOL; CONTROLLED STUDY; CORRELATION FUNCTION; DRUG STRUCTURE; EXON; EXPOSURE; GENE AMPLIFICATION; GENE DELETION; GENE INSERTION; GENETIC DISORDER; INTESTINE; INTRON; MOUSE; MOUSE STRAIN; MURINE LEUKEMIA VIRUS; NEUROTOXICITY; NONHUMAN; PLACENTA; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA PROCESSING; RNA SPLICING; SEQUENCE ANALYSIS; TESTIS;

ANIMALS; BASE SEQUENCE; DNA TRANSPOSABLE ELEMENTS; EXONS; GENE DELETION; GENES, MDR; MICE; MOLECULAR SEQUENCE DATA; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID;

ANIMALIA; MURINAE; MURINE LEUKEMIA VIRUS;

EID: 0035049879     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.3     Document Type: Article

References (19)

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2. The physiological function of drug-transporting P-glycoproteins
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4. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
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14. Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism
15. The chemistry and pharmacology of avermectins
16. Photoaffinity labeling of avermectin binding sites from Caenorhabditis elegans and Drosophila melanogaster
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