Copper-catalyzed ascorbate oxidation results in glyoxal/AGE formation and cytotoxicity

Molecular Nutrition and Food Research

Volumn 51, Issue 4, 2007, Pages 445-455

  Shangari, Nandita ^a   Chan, Tom S ^b   Chan, Katie ^a   Wu, Shuo Huai ^c   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Advanced glycation end products; Ascorbate oxidation; Cataract; Glyoxal; Oxidative stress

Indexed keywords

RATTUS;

ADVANCED GLYCATION END PRODUCT; ASCORBIC ACID; BOVINE SERUM ALBUMIN; COPPER; GLUTATHIONE; GLYOXAL; HYDROGEN PEROXIDE; IMIDAZOLE DERIVATIVE; IMIDAZOLONE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL DEATH; CELL FREE SYSTEM; CELL MEMBRANE POTENTIAL; CHEMISTRY; DRUG EFFECT; LIVER CELL; LIVER MITOCHONDRION; MALE; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; ASCORBIC ACID; CELL DEATH; CELL-FREE SYSTEM; COPPER; GLUTATHIONE; GLYCOSYLATION END PRODUCTS, ADVANCED; GLYOXAL; HEPATOCYTES; HYDROGEN PEROXIDE; IMIDAZOLES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SERUM ALBUMIN, BOVINE;

EID: 34447517609     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200600109     Document Type: Conference Paper

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