The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 285-296

  Teng, Shirley ^a   Beard, Kristin ^a   Pourahmad, Jalal ^a   Moridani, Majid ^a   Easson, Elaine ^b   Poon, Raymond ^b   O'Brien, Peter J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HEALTH CANADA   (Canada)

Author keywords

Alcohol dehydrogenase; Aldehyde dehydrogenase; Formaldehyde; GSH; Mitochondria; Oxidative stress

Indexed keywords

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ANTIOXIDANT; CARNITINE; CYCLOSPORIN; DNA; ENZYME; FORMALDEHYDE; GLUTATHIONE; IRON CHELATING AGENT; PROTEIN; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; CARCINOGENICITY; CELL DEATH; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DNA ADDUCT; DNA POLYMORPHISM; DOSE RESPONSE; ENZYME INHIBITION; GENETIC SUSCEPTIBILITY; LIPID PEROXIDATION; LIVER CELL; LIVER METABOLISM; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; RAT;

ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; ANIMALS; CELL DEATH; ENZYME INHIBITORS; FORMALDEHYDE; GLUTATHIONE; HEPATOCYTES; HUMANS; KINETICS; LIPID PEROXIDATION; MALE; METABOLIC DETOXICATION, DRUG; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 0035969837     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00272-6     Document Type: Conference Paper

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