Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4′-thioadenosine derivatives without 4′-hydroxymethyl group as highly potent and selective antagonists

Journal of Medicinal Chemistry

Volumn 50, Issue 14, 2007, Pages 3159-3162

  Lak, Shin Jeong ^a   Seung, Ah Choe ^a   Gunaga, Prashantha ^a   Hea, Ok Kim ^a   Hyuk, Woo Lee ^a   Sang, Kook Lee ^a   Tosh, Dilip K ^a   Patel, Amit ^b   Palaniappan, Krishnan K ^b   Gao, Zhan Guo ^b   Jacobson, Kenneth A ^b   Hyung, Ryong Moon ^c  

^a Ewha Womans University   (South Korea)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c Pusan National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE DERIVATIVE; CYCLIC AMP; DEXTRO 4' THIOADENOSINE; HYDROXYL GROUP; LIGAND; MANNOSE; METHYL GROUP; N6 (3 CHLOROBENZYL)PURINE DERIVATIVE; NUCLEOSIDE; PURINE DERIVATIVE; THIOL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN;

ADENOSINE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIGANDS; RECEPTOR, ADENOSINE A3; THIONUCLEOSIDES;

EID: 34447508102     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070259t     Document Type: Article

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