The cross-species A3 adenosine-receptor antagonist MRS 1292 inhibits adenosine-triggered human nonpigmented ciliary epithelial cell fluid release and reduces mouse intraocular pressure

Current Eye Research

Volumn 30, Issue 9, 2005, Pages 747-754

  Yang, Hui ^a   Avila, Marcel Y ^a   Peterson Yantorno, Kim ^a   Coca Prados, Miguel ^b   Stone, Richard A ^a   Jacobson, Kenneth A ^c   Civan, Mortimer M ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

A3 adenosine receptors; Aqueous humor inflow; Cl channels; Intraocular pressure; MRS 1292

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 4',5' URONAMIDE DERIVATIVE; 6 ETHYL 4 PROPYL 2 PHENYL 3 PYRIDINECARBOXYLIC ACID 5 THIOCARBOXYLIC ACID 5 ETHYL 3 PROPYL ESTER; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; MRS 1067; MRS 1097; MRS 1292; N 6 (3 IODOBENZYL)ADENOSINE 5' N METHYLURONAMIDE; OT 7999; UNCLASSIFIED DRUG; DIHYDROPYRIDINE DERIVATIVE; DRUG DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL SELECTION; CELL VOLUME; CILIARY BODY EPITHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FEMALE; GLAUCOMA; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR FLUID; INTRAOCULAR PRESSURE; MALE; MICROPIPETTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; ANIMAL; AQUEOUS HUMOR; CELL SIZE; CILIARY BODY; DRUG ANTAGONISM; EPITHELIUM CELL; METABOLISM; TOPICAL DRUG ADMINISTRATION;

ADENOSINE; ADMINISTRATION, TOPICAL; ANIMALS; AQUEOUS HUMOR; CELL SIZE; CELLS, CULTURED; CILIARY BODY; DIHYDROPYRIDINES; EPITHELIAL CELLS; FEMALE; HUMANS; INTRAOCULAR PRESSURE; MALE; MICE; RECEPTOR, ADENOSINE A3;

EID: 22744435457     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.1080/02713680590953147     Document Type: Article

References (44)

1. Brubaker RF, Clinical measurement of aqueous dynamics: Implications for addressing glaucoma. In: Civan MM. Eye's Aqueous Humor: From Secretion to Glaucoma. San Diego: Academic Press, 1998;234-284.
2. Collaborative Normal-Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol. 1998;126:498-505.
3. Collaborative Normal-Tension Glaucoma Study Group. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Am J Ophthalmol. 1998;126:487-497.
4. The AGIS investigators. The advanced glaucoma intervention study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429-440.
5. Do C-W, Civan MM. Basis of chloride transport in ciliary epithelium. J Membr Biol. 2004;200:1-13.
6. 3-subtype adenosine receptors modulate intraocular pressure in the mouse. Br J Pharmacol. 2001;134:241-245.
7. 3 adenosine receptors reduces mouse intraocular pressure. Invest Ophthalmol Vis Sci. 2002;43:3021-3026.
8. 3 receptor ligands: new potential therapy for the treatment of glaucoma. Bioorg Med Chem Lett. 2004;14:3775-3779.
9. 3 adenosine receptor in eyes with pseudoexfoliation syndrome and glaucoma. Invest Ophthalmol Vis Sci. 2005;46:2023-2034.
10. Daines BS, Kent AR, McAleer MS, Crosson CE. Intraocular adenosine levels in normal and ocular-hypertensive patients. J Ocul Pharmacol Ther. 2003;19:113-119.
11. 3 adenosine receptor-selective antagonists. Neuropharmacology. 1997;36:1157-1165.
12. Linden J. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Annu Rev Pharmacol Toxicol. 2001;41:775-787.
13. 3 adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. J Med Chem. 2002;45:4471-4484.
14. 3 receptor. Eur J Pharmacol. 2002;443:39-42.
15. 3 adenosine receptor ligands: history and perspectives. Med Res Rev. 2000;20:103-128.
16. Park KS, Hoffmann C, Kim HO, Padgett WL, Brambilla R, Motta C, Abbracchio MP, Jacobson KA. Activation and desensitization of rat As-adenosine receptors by selective adenosine derivatives and xanthine-7-ribosides. Drug Dev Res. 1998;44:97-105.
17. 3 adenosine receptors. J Med Chem. 1994;37:3614-3621.
18. 3 adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms. Circ Res. 2001;88:520-528.
19. 3 receptor. J Immunol. 2003;171:338-345.
20. Jacobson KA, Kim SK, Costanzi S, Gao ZG. Purine receptors: GPCR structure and agonist design. Molecular Interventions 2004;4:337-347.
21. - channels of nonpigmented ciliary epithelial cells. Am J Physiol. 1999;276:C659-C666.
22. 3-adenosine and swelling-activated Cl(-) channels in nonpigmented ciliary epithelial cells. Am J Physiol Cell Physiol. 2000;279:C440-C451.
23. Martin-Vasallo P, Ghosh S, Coca-Prados M. Expression of Na,K-ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells. J Cell Physiol. 1989;141:243-252.
24. Civan MM, Coca-Prados M, Peterson-Yantorno K. Pathways signaling the regulatory volume decrease of cultured nonpigmented ciliary epithelial cells. Invest Ophthalmol Vis Sci. 1994;35:2876-2886.
25. - channels in pigmented ciliary epithelial cells. Am J Physiol Cell Physiol. 2001;281:C1614-C1623.
26. - channels of nonpigmented ciliary epithelial cells. Am J Physiol. 1997;273:C1354-1361.
27. Avila MY, Carré DA, Stone RA, Civan MM. Reliable measurement of mouse intraocular pressure by a servo-null micropipette system. Invest Ophthalmol Vis Sci. 2001;42:1841-1846.
28. + exchange reduce mouse intraocular pressure. Invest Ophthalmol Vis Sci. 2002;43:1897-1902.
29. Reitsamer HA, Kiel JW, Harrison JM, Ransom NL, McKinnon SJ. Tonopen measurement of intraocular pressure in mice. Exp Eye Res. 2004;78:799-804.
30. Crosson CE, Adenosine receptor activation modulates intraocular pressure in rabbits. J Pharmacol Exp Ther. 1995;273:320-326.
31. Crosson CE, Gray T. Characterization of ocular hypertension induced by adenosine agonists. Invest Ophthalmol Vis Sci. 1996;37:1833-1839.
32. Tian B, Gabelt BT, Crosson CE, Kaufman PL. Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys. Exp Eye Res. 1997;64:979-989.
33. Mitchell CH, Peterson-Yantorno K, Coca-Prados M, Civan MM. Tamoxifen and ATP synergistically activate Cl- release by cultured bovine pigmented ciliary epithelial cells. J Physiol. 2000;525 (Pt)1:183-193.
34. Do C-W, Peterson-Yantorno K, Mitchell CH, Civan MM. cAMP-Activated Maxi-Cl- Channels in native bovine pigmented ciliary epithelial cells. Am J Physiol Cell Physiol. 2004;287:C1003-1011. Epub 2004 Jun 09 10.1152/ajpcell. 00175.2004.
35. O'Brien WJ, Edelhauser HF. The corneal penetration of trifluorothymidine, adenine arabinoside, and idoxuridine: a comparative study. Invest Ophthalmol Vis Sci. 1977;16:1093-1103.
36. 3 adenosine receptor. J Biol Chem. 2002;277:19056-19063.
37. 3 adenosine receptor antagonists. Mini Rev Med Chem. 2001;1:417-427.
38. 3 receptors. J Med Chem. 1996;39:2980-2989.
39. 3 receptors: novel ligands and paradoxical effects. Trends Pharmacol Sci 1998;19:184-191.
40. 3 adenosine receptor antagonists. J Med Chem. 1999;42:706-721.
41. 3 adenosine receptors. Mol Pharmacol. 2000;57:968-975.
42. 3-adenosine receptors. Drug Devel Res. 1994;33:51-59.
43. 3 adenosine receptors. Biochem Pharmacol. 2003;65:1675-1684.
44. Civan MM, Macknight AD. The ins and outs of aqueous humour secretion. Exp Eye Res. 2004;78:625-631.