Novel N6-substituted adenosine 5′-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 285, Issue 6 54-6, 2003, Pages

  Tracey, W Ross ^a   Magee, William P ^a   Oleynek, Joseph J ^a   Hill, Roger J ^a   Smith, Andrew H ^a   Flynn, David M ^a   Knight, Delvin R ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Heart; Infarct; Ischemia; Rabbit; Reperfusion

Indexed keywords

3 AMINO 5 [6 (2,5 DICHLOROBENZYLAMINO)PURIN 9 YL] 4 HYDROXYTETRAHYDROFURAN 2 CARBOXYLIC ACID METHYLAMIDE; 3 AMINO 5 [6 [5 CHLORO 2 (3 METHYLISOXAZOL 5 YLMETHOXY)BENZYLAMINO]PURIN 9 YL] 4 HYDROXYTETRAHYDROFURAN 2 CARBOXYLIC ACID METHYLAMIDE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR BLOCKING AGENT; BW A1433U; CP 532 903; CP 608 039; UNCLASSIFIED DRUG; ADENOSINE; CP 532,903; CP 53261; CP 608039; CP-532,903; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FURAN DERIVATIVE; ISOXAZOLE DERIVATIVE; PURINE DERIVATIVE; RADIOACTIVE IODINE; SERTRALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RECEPTOR SENSITIVITY; ANIMAL; CHEMISTRY; CHO CELL; DISEASE MODEL; DOSE RESPONSE; DRUG POTENTIATION; GENETIC TRANSFECTION; GENETICS; HAMSTER; HEART INFARCTION; HUMAN; METABOLISM; RADIOASSAY; REPERFUSION INJURY;

ADENOSINE; ANIMALS; CHO CELLS; CRICETINAE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FURANS; HUMANS; IODINE RADIOISOTOPES; ISOXAZOLES; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PURINES; RABBITS; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; SERTRALINE; TRANSFECTION;

EID: 0344440751     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00411.2003     Document Type: Article

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