메뉴 건너뛰기




Volumn 27, Issue 14, 2007, Pages 5235-5245

Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-κB activation

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; PROTEIN BCL 10; T LYMPHOCYTE RECEPTOR;

EID: 34447503930     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01645-06     Document Type: Article
Times cited : (34)

References (64)
  • 1
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κ B and I κ B proteins: New discoveries and insights
    • Baldwin, A. S., Jr. 1996. The NF-κ B and I κ B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
    • (1996) Annu. Rev. Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 4
    • 33745937881 scopus 로고    scopus 로고
    • Proteasome-dependent down-regulation of activated Stat5A in the nucleus
    • Chen, Y., X. Dai, A. L. Haas, R. Wen, and D. Wang. 2006. Proteasome-dependent down-regulation of activated Stat5A in the nucleus. Blood 108: 566-574.
    • (2006) Blood , vol.108 , pp. 566-574
    • Chen, Y.1    Dai, X.2    Haas, A.L.3    Wen, R.4    Wang, D.5
  • 5
    • 0033047309 scopus 로고    scopus 로고
    • Integration of T cell receptor-dependent signaling pathways by adapter proteins
    • Clements, J. L., N. J. Boerth, J. R. Lee, and G. A. Koretzky. 1999. Integration of T cell receptor-dependent signaling pathways by adapter proteins. Annu. Rev. Immunol. 17:89-108.
    • (1999) Annu. Rev. Immunol , vol.17 , pp. 89-108
    • Clements, J.L.1    Boerth, N.J.2    Lee, J.R.3    Koretzky, G.A.4
  • 6
    • 0033575211 scopus 로고    scopus 로고
    • c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-κB
    • Costanzo, A., C. Guiet, and P. Vito. 1999. c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-κB. J. Biol. Chem. 274: 20127-20132.
    • (1999) J. Biol. Chem , vol.274 , pp. 20127-20132
    • Costanzo, A.1    Guiet, C.2    Vito, P.3
  • 9
    • 0035843970 scopus 로고    scopus 로고
    • Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation
    • Gaide, O., F. Martinon, O. Micheau, D. Bonnet, M. Thome, and J. Tschopp. 2001. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-κB activation. FEBS Lett. 496:121-127.
    • (2001) FEBS Lett , vol.496 , pp. 121-127
    • Gaide, O.1    Martinon, F.2    Micheau, O.3    Bonnet, D.4    Thome, M.5    Tschopp, J.6
  • 10
    • 0031833431 scopus 로고    scopus 로고
    • The regulation and roles of Rel/NF-κ B transcription factors during lymphocyte activation
    • Gerondakis, S., R. Grumont, I. Rourke, and M. Grossmann. 1998. The regulation and roles of Rel/NF-κ B transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10:353-359.
    • (1998) Curr. Opin. Immunol , vol.10 , pp. 353-359
    • Gerondakis, S.1    Grumont, R.2    Rourke, I.3    Grossmann, M.4
  • 11
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109(Suppl.):S81-S96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 12
    • 0031897632 scopus 로고    scopus 로고
    • NF-κ B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-κ B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225-260.
    • (1998) Annu. Rev. Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 13
    • 8644283766 scopus 로고    scopus 로고
    • The molecular adapter Carmal controls entry of IκB kinase into the central immune synapse
    • Hara, H., C. Bakal, T. Wada, D. Bouchard, R. Rottapel, T. Saito, and J. M. Penninger. 2004. The molecular adapter Carmal controls entry of IκB kinase into the central immune synapse. J. Exp. Med. 200:1167-1177.
    • (2004) J. Exp. Med , vol.200 , pp. 1167-1177
    • Hara, H.1    Bakal, C.2    Wada, T.3    Bouchard, D.4    Rottapel, R.5    Saito, T.6    Penninger, J.M.7
  • 15
    • 0026672334 scopus 로고
    • Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus
    • Hawley, R. G., A. Z. Fong, B. F. Burns, and T. S. Hawley. 1992. Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J. Exp. Med. 176:1149-1163.
    • (1992) J. Exp. Med , vol.176 , pp. 1149-1163
    • Hawley, R.G.1    Fong, A.Z.2    Burns, B.F.3    Hawley, T.S.4
  • 17
    • 0030837598 scopus 로고    scopus 로고
    • Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
    • Horwitz, B. H., M. L. Scott, S. R. Cherry, R. T. Bronson, and D. Baltimore. 1997. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity 6:765-772.
    • (1997) Immunity , vol.6 , pp. 765-772
    • Horwitz, B.H.1    Scott, M.L.2    Cherry, S.R.3    Bronson, R.T.4    Baltimore, D.5
  • 20
    • 0038578823 scopus 로고    scopus 로고
    • The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3
    • Kane, L. P., and A. Weiss. 2003. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol. Rev. 192: 7-20.
    • (2003) Immunol. Rev , vol.192 , pp. 7-20
    • Kane, L.P.1    Weiss, A.2
  • 21
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[κ]B activity
    • Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-[κ]B activity. Annu. Rev. Immunol. 18:621-663.
    • (2000) Annu. Rev. Immunol , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 22
    • 0033537840 scopus 로고    scopus 로고
    • CIPER, a novel NF κB-activating protein containing a caspase recruitment domain with homology to herpesvirus-2 protein E10
    • Koseki, T., N. Inohara, S. Chen, R. Carrio, J. Merino, M. O. Hottiger, G. J. Nabel, and G. Nunez. 1999. CIPER, a novel NF κB-activating protein containing a caspase recruitment domain with homology to herpesvirus-2 protein E10. J. Biol. Chem. 274:9955-9961.
    • (1999) J. Biol. Chem , vol.274 , pp. 9955-9961
    • Koseki, T.1    Inohara, N.2    Chen, S.3    Carrio, R.4    Merino, J.5    Hottiger, M.O.6    Nabel, G.J.7    Nunez, G.8
  • 23
    • 0036781052 scopus 로고    scopus 로고
    • NF-κB regulation in the immune system
    • Li, Q., and I. M. Verma. 2002. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2:725-734.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 24
    • 8444225946 scopus 로고    scopus 로고
    • The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling
    • Lin, X., and D. Wang. 2004. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin. Immunol. 16:429-435.
    • (2004) Semin. Immunol , vol.16 , pp. 429-435
    • Lin, X.1    Wang, D.2
  • 25
    • 0035374349 scopus 로고    scopus 로고
    • Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κ B signaling pathway
    • Lucas, P. C., M. Yonezumi, N. Inohara, L. M. McAllister-Lucas, M. E. Abazeed, F. F. Chen, S. Yamaoka, M. Seto, and G. Nunez. 2001. Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-κ B signaling pathway. J. Biol. Chem. 276:19012-19019.
    • (2001) J. Biol. Chem , vol.276 , pp. 19012-19019
    • Lucas, P.C.1    Yonezumi, M.2    Inohara, N.3    McAllister-Lucas, L.M.4    Abazeed, M.E.5    Chen, F.F.6    Yamaoka, S.7    Seto, M.8    Nunez, G.9
  • 26
    • 0037082448 scopus 로고    scopus 로고
    • Maes, B., A. Demunter, B. Peeters, and C. De Wolf-Peeters. 2002. BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression. Blood 99:1398-1404.
    • Maes, B., A. Demunter, B. Peeters, and C. De Wolf-Peeters. 2002. BCL10 mutation does not represent an important pathogenic mechanism in gastric MALT-type lymphoma, and the presence of the API2-MLT fusion is associated with aberrant nuclear BCL10 expression. Blood 99:1398-1404.
  • 27
    • 28844499919 scopus 로고    scopus 로고
    • Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation
    • Matsumoto, R., D. Wang, M. Blonska, H. Li, M. Kobayashi, B. Pappu, Y. Chen, D. Wang, and X. Lin. 2005. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-κB activation. Immunity 23:575-585.
    • (2005) Immunity , vol.23 , pp. 575-585
    • Matsumoto, R.1    Wang, D.2    Blonska, M.3    Li, H.4    Kobayashi, M.5    Pappu, B.6    Chen, Y.7    Wang, D.8    Lin, X.9
  • 30
    • 0038037580 scopus 로고    scopus 로고
    • Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes
    • Newton, K., and V. M. Dixit. 2003. Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes. Curr. Biol. 13:1247-1251.
    • (2003) Curr. Biol , vol.13 , pp. 1247-1251
    • Newton, K.1    Dixit, V.M.2
  • 31
    • 0023219884 scopus 로고
    • Antibody-induced modulation of the CD3AT cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation
    • Pantaleo, G., D. Olive, A. Poggi, T. Pozzan, L. Moretta, and A. Moretta. 1987. Antibody-induced modulation of the CD3AT cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation. J. Exp. Med. 166:619-624.
    • (1987) J. Exp. Med , vol.166 , pp. 619-624
    • Pantaleo, G.1    Olive, D.2    Poggi, A.3    Pozzan, T.4    Moretta, L.5    Moretta, A.6
  • 32
    • 0034192088 scopus 로고    scopus 로고
    • The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells
    • Rao, N., M. L. Lupher, Jr., S. Ota, K. A. Reedquist, B. J. Druker, and H. Band. 2000. The linker phosphorylation site Tyr292 mediates the negative regulatory effect of Cbl on ZAP-70 in T cells. J. Immunol. 164:4616- 4626.
    • (2000) J. Immunol , vol.164 , pp. 4616-4626
    • Rao, N.1    Lupher Jr., M.L.2    Ota, S.3    Reedquist, K.A.4    Druker, B.J.5    Band, H.6
  • 34
    • 0033534533 scopus 로고    scopus 로고
    • Adaptors and molecular scaffolds in immune cell signaling
    • Rudd, C. E. 1999. Adaptors and molecular scaffolds in immune cell signaling. Cell 96:5-8.
    • (1999) Cell , vol.96 , pp. 5-8
    • Rudd, C.E.1
  • 35
    • 0345374583 scopus 로고    scopus 로고
    • Regulation of NF-κB-dependent lymphocyte activation and development by paracaspase
    • Ruefli-Brasse, A. A., D. M. French, and V. M. Dixit. 2003. Regulation of NF-κB-dependent lymphocyte activation and development by paracaspase. Science 302:1581-1584.
    • (2003) Science , vol.302 , pp. 1581-1584
    • Ruefli-Brasse, A.A.1    French, D.M.2    Dixit, V.M.3
  • 37
    • 0345358541 scopus 로고    scopus 로고
    • Differential requirement for Malt1 in T and B cell antigen receptor signaling
    • Ruland, J., G. S. Duncan, A. Wakeham, and T. W. Mak. 2003. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 19:749-758.
    • (2003) Immunity , vol.19 , pp. 749-758
    • Ruland, J.1    Duncan, G.S.2    Wakeham, A.3    Mak, T.W.4
  • 38
    • 0037124307 scopus 로고    scopus 로고
    • Protein kinase C beta controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase alpha
    • Saijo, K., I. Mecklenbrauker, A. Santana, M. Leitger, C. Schmedt, and A. Tarakhovsky. 2002. Protein kinase C beta controls nuclear factor κB activation in B cells through selective regulation of the IκB kinase alpha. J. Exp. Med. 195:1647-1652.
    • (2002) J. Exp. Med , vol.195 , pp. 1647-1652
    • Saijo, K.1    Mecklenbrauker, I.2    Santana, A.3    Leitger, M.4    Schmedt, C.5    Tarakhovsky, A.6
  • 39
    • 0034288890 scopus 로고    scopus 로고
    • Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism
    • San Jose, E., A. Borroto, F. Niedergang, A. Alcover, and B. Alarcon. 2000. Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism. Immunity 12:161-170.
    • (2000) Immunity , vol.12 , pp. 161-170
    • San Jose, E.1    Borroto, A.2    Niedergang, F.3    Alcover, A.4    Alarcon, B.5
  • 40
    • 0742270964 scopus 로고    scopus 로고
    • Complex and dynamic redistribution of NF-κB signaling intermediates in response to T cell receptor stimulation
    • Schaefer, B. C., J. W. Kappler, A. Kupfer, and P. Marrack. 2004. Complex and dynamic redistribution of NF-κB signaling intermediates in response to T cell receptor stimulation. Proc. Natl. Acad. Sci. USA 101:1004-1009.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1004-1009
    • Schaefer, B.C.1    Kappler, J.W.2    Kupfer, A.3    Marrack, P.4
  • 41
    • 1942453854 scopus 로고    scopus 로고
    • Degradation of Bcl10 induced by T-cell activation negatively regulates NF-κB signaling
    • Scharschmidt, E., E. Wegener, V. Heissmeyer, A. Rao, and D. Krappmann. 2004. Degradation of Bcl10 induced by T-cell activation negatively regulates NF-κB signaling. Mol. Cell. Biol. 24:3860-3873.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 3860-3873
    • Scharschmidt, E.1    Wegener, E.2    Heissmeyer, V.3    Rao, A.4    Krappmann, D.5
  • 43
    • 20644455960 scopus 로고    scopus 로고
    • Control of lymphocyte development by nuclear factor-κB
    • Siebenlist, U., K. Brown, and E. Claudio. 2005. Control of lymphocyte development by nuclear factor-κB. Nat. Rev. Immunol. 5:435-445.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 435-445
    • Siebenlist, U.1    Brown, K.2    Claudio, E.3
  • 45
    • 0033580935 scopus 로고    scopus 로고
    • CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis
    • Srinivasula, S. M., M. Ahmad, J. H. Lin, J. L. Poyet, T. Fernandes-Alnemri, P. N. Tsichlis, and E. S. Alnemri. 1999. CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-κB activation and apoptosis. J. Biol. Chem. 274:17946-17954.
    • (1999) J. Biol. Chem , vol.274 , pp. 17946-17954
    • Srinivasula, S.M.1    Ahmad, M.2    Lin, J.H.3    Poyet, J.L.4    Fernandes-Alnemri, T.5    Tsichlis, P.N.6    Alnemri, E.S.7
  • 48
    • 2442612540 scopus 로고    scopus 로고
    • CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
    • Thome, M. 2004. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat. Rev. Immunol. 4:348-359.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 348-359
    • Thome, M.1
  • 49
    • 0033537851 scopus 로고    scopus 로고
    • Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase
    • Thome, M., F. Martinon, K. Hofmann, V. Rubio, V. Steiner, P. Schneider, C. Mattmann, and J. Tschopp. 1999. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-κB transcription factor and c-Jun N-terminal kinase. J. Biol. Chem. 274:9962-9968.
    • (1999) J. Biol. Chem , vol.274 , pp. 9962-9968
    • Thome, M.1    Martinon, F.2    Hofmann, K.3    Rubio, V.4    Steiner, V.5    Schneider, P.6    Mattmann, C.7    Tschopp, J.8
  • 50
    • 0033638182 scopus 로고    scopus 로고
    • Identification of paracaspases and metacaspases: Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma
    • Uren, A. G., K. O'Rourke, L. A. Aravind, M. T. Pisabarro, S. Seshagiri, E. V. Koonin, and V. M. Dixit. 2000. Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol. Cell 6:961-967.
    • (2000) Mol. Cell , vol.6 , pp. 961-967
    • Uren, A.G.1    O'Rourke, K.2    Aravind, L.A.3    Pisabarro, M.T.4    Seshagiri, S.5    Koonin, E.V.6    Dixit, V.M.7
  • 51
    • 1842331510 scopus 로고    scopus 로고
    • Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation
    • Valitutti, S., S. Muller, M. Salio, and A. Lanzavecchia. 1997. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J. Exp. Med. 185:1859-1864.
    • (1997) J. Exp. Med , vol.185 , pp. 1859-1864
    • Valitutti, S.1    Muller, S.2    Salio, M.3    Lanzavecchia, A.4
  • 52
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273:104-106.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 53
    • 0346993668 scopus 로고    scopus 로고
    • CD3/CD28 costimulation-induced NF-κB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IκB kinase beta to the immunological synapse through CARMA1
    • Wang, D., R. Matsumoto, Y. You, T. Che, X. Y. Lin, S. L. Gaffen, and X. Lin. 2004. CD3/CD28 costimulation-induced NF-κB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IκB kinase beta to the immunological synapse through CARMA1. Mol. Cell. Biol. 24:164-171.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 164-171
    • Wang, D.1    Matsumoto, R.2    You, Y.3    Che, T.4    Lin, X.Y.5    Gaffen, S.L.6    Lin, X.7
  • 56
    • 8144221736 scopus 로고    scopus 로고
    • An important role of phospholipase Cγ1 in pre-B-cell development and allelic exclusion
    • Wen, R., Y. Chen, J. Schuman, G. Fu, S. Yang, W. Zhang, D. K. Newman, and D. Wang. 2004. An important role of phospholipase Cγ1 in pre-B-cell development and allelic exclusion. EMBO J. 23:4007-4017.
    • (2004) EMBO J , vol.23 , pp. 4007-4017
    • Wen, R.1    Chen, Y.2    Schuman, J.3    Fu, G.4    Yang, S.5    Zhang, W.6    Newman, D.K.7    Wang, D.8
  • 57
    • 0242321892 scopus 로고    scopus 로고
    • Phospholipase Cγ2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells
    • Wen, R., Y. Chen, L. Xue, J. Schuman, S. Yang, S. W. Morris, and D. Wang. 2003. Phospholipase Cγ2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells. J. Biol. Chem. 278:43654- 43662.
    • (2003) J. Biol. Chem , vol.278 , pp. 43654-43662
    • Wen, R.1    Chen, Y.2    Xue, L.3    Schuman, J.4    Yang, S.5    Morris, S.W.6    Wang, D.7
  • 60
    • 0041381357 scopus 로고    scopus 로고
    • Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells
    • Xue, L., S. W. Morris, C. Orihuela, E. Tuomanen, X. Cui, R. Wen, and D. Wang. 2003. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat. Immunol. 4:857-865.
    • (2003) Nat. Immunol , vol.4 , pp. 857-865
    • Xue, L.1    Morris, S.W.2    Orihuela, C.3    Tuomanen, E.4    Cui, X.5    Wen, R.6    Wang, D.7
  • 61
    • 0033537887 scopus 로고    scopus 로고
    • mE10, a novel caspase recruitment domain-containing proapoptotic molecule
    • Yan, M., J. Lee, S. Schilbach, A. Goddard, and V. Dixit. 1999. mE10, a novel caspase recruitment domain-containing proapoptotic molecule. J. Biol. Chem. 274:10287-10292.
    • (1999) J. Biol. Chem , vol.274 , pp. 10287-10292
    • Yan, M.1    Lee, J.2    Schilbach, S.3    Goddard, A.4    Dixit, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.