Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: Compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue

Journal of Biological Chemistry

Volumn 282, Issue 22, 2007, Pages 16681-16690

  Ichimura, Shizuo ^a,b   Uchida, Takeshi ^a,c   Taniguchi, Shuhei ^b   Hira, Shusuke ^b   Tosha, Takehiko ^b,c   Morishima, Isao ^b   Kitagawa, Teizo ^c,e   Ishimori, Koichiro ^a,d  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

^d INSTITUTE FOR MOLECULAR SCIENCE   (Japan)

^e TOYOTA PHYSICAL AND CHEMICAL RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

HEME-LIGATED PEROXIDE; MUTATION;

AMINES; AMINO ACIDS; GENETIC ENGINEERING; HYDROGEN BONDS;

ENZYME ACTIVITY;

AMINO ACID; ARGININE; ASPARAGINE; CARBON; GLUTAMINE; IRON; OXYGEN; PEROXIDASE; PEROXIDE; PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE 2; PROSTAGLANDIN SYNTHASE; UNCLASSIFIED DRUG; VALINE; WATER; CYCLOOXYGENASE 2; HEME; MEMBRANE PROTEIN; PROSTAGLANDIN H2; PTGS2 PROTEIN, HUMAN; VEGETABLE PROTEIN;

ABSORPTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; GENE MUTATION; HUMAN; MUTANT; PRIORITY JOURNAL; PROTEIN INTERACTION; RAMAN SPECTROMETRY; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; COMPARATIVE STUDY; ENZYMOLOGY; GENETICS; HYDROGEN BOND; METABOLISM; MISSENSE MUTATION; PLANT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ARGININE; CYCLOOXYGENASE 2; GLUTAMINE; HEME; HUMANS; HYDROGEN BONDING; IRON; MEMBRANE PROTEINS; MUTATION, MISSENSE; PEROXIDASE; PEROXIDES; PLANT PROTEINS; PLANTS; PROSTAGLANDIN H2; SPECIES SPECIFICITY; SPECTRUM ANALYSIS, RAMAN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34447503408     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610785200     Document Type: Article

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