Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 3, 1997, Pages 1069-1075

  Zhang, Yan ^a   Shaffer, Alex ^a   Portanova, Joseph ^a   Seibert, Karen ^a   Isakson, Peter C ^a,b  

^a PFIZER INC   (United States)

^b MONSANTO COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; CYCLOOXYGENASE 2; KETOROLAC; POLYSORBATE 20; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; HYPERALGESIA; INFLAMMATION; MACULA DENSA; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN METABOLISM; RAT; STIMULUS RESPONSE; TURNOVER TIME;

ANIMALS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; HYPERALGESIA; INFLAMMATION; KETOROLAC; MALE; RATS; RATS, SPRAGUE-DAWLEY; TOLMETIN;

EID: 0031473814     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. BOYCE, S., CHAN, C. -C., GORDON, R., LI, C. -S., RODGER, I. W., WEBB, J. K., RUPNIAK, N. M. J. AND HILL, R. G.: L-745,337: A selective inhibitor of cyclooxygenase-2 elicits anti-nociception but not gastric ulceration in rats. Neuropharmacology 33: 1609-1611, 1994.
2. 1 on rat cutaneous afferent nerve activity. Br. J. Pharm. 64: 343-347, 1977.
3. CHAN, C., BOYCE, S., BRIDEAU, C., FORD-HUTCHINSON, A. W., GORDON, R., GUAY, D., HILL, R. G., LI, C., MANCINI, J., PENNETON, M., PRASIT, P., RASORI, R., RIENDEAU, D., ROY, P., TAGARI, P., VICKERS, P., WONG, E. AND RODGER, I. W.: Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: A novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J. Pharmacol. Exp. Ther. 274: 1531-1537, 1995.
4. CHEN, J., MARSH, T., ZHANG, J. S. AND GRAHAM, S, H.: Expression of cyclooxygenase 2 in rat brain following kainate treatment. Neuroreport 6: 245-248, 1995.
5. 2 is noradrenergic terminal-dependent. Neurosci. Lett. 115: 253-258, 1990.
6. COHEN, M. M. AND PERL, E. R.: Contributions of arachidonic acid derivatives and substance P to the sensitization of cutaneous nociceptors. J. Neurophysiol. 64: 457-464, 1990.
7. COPELAND, R. A., WILLIAMS, J. M., GIANNARAS, J., NURNBERG, S., COVINGTON, J., PINTO, D., PICK, S. AND TRZASKOS, J. M.: Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase. Proc. Natl. Acad. Sci. U.S.A. 91: 11202-11206, 1994.
8. DEWITT, D.: Prostaglandin endoperoxide synthase: Regulation of enzyme expression. Biochim. Biophys. Acta. 1083: 121-134, 1991.
9. DUBUISSON, D. AND DENNIS, S. G.: The formalin test: A quantitative study of the effects of morphine, meperidine and brain stem stimulation in rats and cats. Pain 4: 161-174, 1977.
10. FU, J., MASFERRER, J., SEIBERT, K., RAZ, A. AND NEEDLEMAN, P.: The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes. J. Biol. Chem. 265: 16737, 1990.
11. FUTAKI, N., YOSHIKAWA, K., YUMIKO, H., ARAI, I., HIGUCHI, S., IZUKA, H. AND OTOMO, S.: NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effect, which causes minimal stomach lesions. Gen. Pharmacol. 24: 105-110, 1993.
12. GIERSE, J. K., HAUSER, S. D., CREELY, D. P., KOBOLDT, C., RANGWALA, S. H., ISAKSON, P. C. AND SEIBERT, K.: Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase. Biochem. J. 305: 479-484, 1995.
13. HARGREAVES, K., DUBNER, R., BROWN, F., FLORES, C. AND JORIS, J.: A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32: 77-88, 1988.
14. HARRIS, R. C., MCKANNA, J. A., AKAI, Y., JACOBSON, H. R., DUBOIS, R. N. AND BREYER, M. D.: Cyclooxygenase-2 is associated with the macula densa of rat kidney, and increases with salt restriction. J. Clin. Invest. 94: 2504-2510, 1994.
15. INSEL, P. A.: Analgesic-antipyretic and anti-inflammatory agents and drugs employed in the treatment of gout. In Goodman and Gilman's The Pharmacological Basis of Therapeutics. 9th ed., ed. by J. G. Hardman, A. G. Gilman and L. E. Limbird, pp. 617-657, McGraw-Hill, New York, 1996.
16. KAUFMANN, W. E., WORLEY, P. F., PEGG, J., BREMER, P. AND ISAKSON, P. C.: COX-2: A synaptically induced enzyme is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U.S.A. 93: 2317-2321, 1996.
17. KUJUBU, D. A., FLETCHER, B. S., VARNUM, B. C., LIM, R. W. AND HERSCHMAN, H. R.: TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J. Biol. Chem. 266: 12866-12872, 1991.
18. LANEUVILLE, O., BREUER, D. K., DEWITT, D. L., HLA, T., FUNK, C. D. AND SMITH, W. L.: Differential inhibition of human prostaglandin endoperoxide H synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J. Pharmacol. Exp. Ther. 271: 927-934, 1994.
19. MALMBERG, A. B. AND YAKSH, T. L.: Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science (Wash. DC) 257: 1276-1279, 1992a.
20. MALMBERG, A. B. AND YAKSH, T. L.: Anti-nociceptive actions of spinal non-steroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 263: 136-145, 1992b.
21. MALMBERG, A. B. AND YAKSH, T. L.: Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats. J. Neurosci. 15: 2768-2776, 1995.
22. MARCHESELLI, V. L. AND BAZAN, N. G.: Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. J. Biol. Chem. 271: 24794-24799, 1996.
23. MARTIN, H. A., BASBAUM, A. I., KWIAT, G. C., GOETZL, E. J. AND LEVINE, J. D.: Leukotriene and prostaglandin sensitization of cutaneous high-threshold C and A-delta mechanoceptors in the hairy skin of rat hindlimbs. Neuroscience 22: 651-659, 1987.
24. MASFERRER, J. L., SEIBERT, K., ZWEIFEL, B. AND NEEDLEMAN, P.: Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme. Proc. Natl. Acad. Sci. U.S.A. 89(9): 3917-3921, 1992.
25. MASFERRER, J. L., ZWEIFEL, B. S., MANNING, P. T., HAUSER, S. D., LEAHY, K. M., SMITH, W. G., ISAKSON, P. C. AND SEIBERT, K.: Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and non-ulcerogenic. Proc. Natl. Acad. Sci. U.S.A. 91: 3228-3232, 1994.
26. MITCHELL, J. A., AKARASEREENONT, P., THIEMERMANN, C., FLOWER, R. J. AND VANE, J. R.: Selectivity of non-steroidal anti-inflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. U.S.A. 90: 11693-11697, 1993.
27. 2. J. Immunol. 155: 4437-4444, 1995.
28. O'BANION, M. K., SADOWSKI, H. B., WINN, V. AND YOUNG, D. A.: A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. J. Biol. Chem. 266: 23261-23267, 1991.
29. OTTERNESS, I. G. AND BLIVEN, M. L.: Laboratory models for testing nonsteroidal anti-inflammatory drugs. In Non-steroidal Anti-inflammatory Drugs, ed. by J. G. Lombardino, pp. 111-252, Wiley, New York, 1985.
30. PENNING, T. D., TALLEY, J. J., BERTENSHAW, S. R., CARTER, J. S., COLLINS, P. W., DOCTER, S. D., GRANETO, M. J., LEE, L. F., MALECHA, J. W., MIYASHIRO, J. M., ROGERS, R. S., ROGIER, D. J., YU, S. S., ANDERSON, G. D., COGBURN, J. N., GREGORY, S. A., KOBOLDT, C. M., PERKINS, W. E., SEIBERT, K., VEENHUIZEN, A. W., ZHANG, Y. AND ISAKSON, P. C.: Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of SC-58635 (celecoxib). J. Med. Chem. 40: 1347-1365, 1997.
31. 2 blocks inflammation, hyperalgesia, and interleukin 6 production in vivo. J. Exp. Med. 184: 883-891, 1996.
32. RAMWELL, P. W., SHAW, J. D. AND JESSUP, R.: Spontaneous and evoked release of prostaglandins from frog spinal cord. Am. J. Physiol. 211: 998-1004, 1966.
33. SALVEMINI, D., WANG, Z-Q., WYATT, P. S., BOURDON, D. M., MARINO, M. H., MANNING, P. T. AND CURRIE, M. G.: Nitric oxide: A key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118: 829-838, 1996.
34. SEIBERT, K., ZHANG, Y., LEAHY, K., HAUSER, S., MASFERRER, J., PERKINS, W., LEE, L. AND ISAKSON, P. C.: Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. U.S.A. 91: 12013-12017, 1994.
35. SMITH, J. B, AND WILLIS, A. L.: Aspirin selectively inhibits prostaglandin production in human platelets. Nature (Lond.) New Biol. 231: 235-239, 1971.
36. SMITH, W. L. AND DEWITT, D. L.: Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. Adv. Immunol. 62: 167-215, 1996.
37. TROULLOW E. S., HARGREAVES, K. M., BUTLER, D. P. AND DIONNE, R. A.: Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus. J. Oral Maxillofac. Surg. 48: 945-952, 1990.
38. VANE, J. R. AND BOTTING, R. M.: Biological properties of cyclooxygenase products. In Lipid Mediators, ed. by F. Cunningham, pp. 61-97, Academic Press Limited, New York, 1994.
39. VANE, J. R., MITCHELL, J. A., APPLETON, I., TOMLINSON, A., BISHOP-BAILEY, D., CROXTALL, J. AND WILLOUGHBY, D. A.: Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc. Natl. Acad. Sci. U.S.A. 91: 2046-2050, 1994.
40. VANE, J. R.: Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs. Nature (Lond.) New Biol. 231: 232-235, 1971.
41. WINTER, C. A., RISLEY, E. A. AND NUSS, G. W.: Carrageenan-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Proc. Soc. Exp. Biol. Med. 111: 544-552, 1962.
42. XIE, W., CHIPMAN, J. G., ROBERTSON, D. L., ERIKSON, R. L. AND SIMMONS, D. L.: Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proc. Natl. Acad. Sci. U.S.A. 88: 2692-2696, 1991.
43. YAKSH, T. L.: The spinal pharmacology of facilitation of afferent processing evoked by high-threshold afferent input of the post-injury pain state. Curr. Opin. Neurol. Neurosurg. 6: 250-256, 1993.
44. YAKSH, T. L.: Central and peripheral mechanisms for the analgesic action of acetylsalicylic acid. In Acetylsalicylic Acid: New Uses for an Old Drug, ed. by H. Barett, M. Ju, J. Hirsh and J. F. Mustard, pp. 137-151, Raven Press, New York, 1982.
45. YAMAGATA, K., ANDREASSON, K. I., KAUFMANN, W. E., BARNES, C. A. AND WORLEY, P. F.: Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids. Neuron 11: 371-386, 1993.
46. YAMAMOTO, T. AND NOZAKI-TAGUCHI, N.: Analysis of the effects of cylooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor. Brain Res. 739: 104-110, 1996.