Synthesis of 4-phenoxybenzamide adenine dinucleotide as NAD analogue with inhibitory activity against enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4588-4591

  Bonnac, Laurent ^a   Gao, Guang Yao ^a   Chen, Liqiang ^a   Felczak, Krzysztof ^a   Bennett, Eric M ^a   Xu, Hua ^b   Kim, TaeSoo ^b   Liu, Nina ^b   Oh, HyeWon ^b   Tonge, Peter J ^b   Pankiewicz, Krzysztof W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

Enoyl ACP reductase (InhA); Fragment based drug discovery; Isoniazid; M. tuberculosis; NAD analogues

Indexed keywords

4 PHENOXY BENZAMIDE RIBOSIDE; 4 PHENOXYBENZAMIDE ADENINE DINUCLEOTIDE; DINUCLEOTIDE; IMIDAZOLE; ISONIAZID; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN;

ADENINE NUCLEOTIDES; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NAD; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

MYCOBACTERIUM TUBERCULOSIS;

EID: 34447336119     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.084     Document Type: Article

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