The practical synthesis of a methylenebisphosphonate analogue of benzamide adenine dinucleotide: Inhibition of human inosine monophosphate dehydrogenase (type I and II)

Journal of Medicinal Chemistry

Volumn 40, Issue 8, 1997, Pages 1287-1291

  Pankiewicz, K W ^a   Lesiak, K ^a   Zatorski, A ^a   Goldstein, B M ^a   Carr, S F ^a   Sochacki, M ^a   Majumdar, A ^a   Seidman, M ^a   Watanabe, K A ^a  

^a Division of Medicinal Chemistry   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA METHYLENE BENZAMIDE ADENINE DINUCLEOTIDE; INOSINATE DEHYDROGENASE; INOSINATE DEHYDROGENASE INHIBITOR; MEDRONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; INHIBITION KINETICS; REACTION ANALYSIS;

ADENINE NUCLEOTIDES; ALCOHOL DEHYDROGENASE; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BENZAMIDES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; HORSES; HUMANS; IMP DEHYDROGENASE; ISOENZYMES; KINETICS; LIVER; TUMOR CELLS, CULTURED;

EID: 0030907934     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960641y     Document Type: Article

References (33)