Effects of the dual endothelin receptor antagonist tezosentan and hypertonic saline/dextran on porcine endotoxin shock

Acta Physiologica

Volumn 190, Issue 4, 2007, Pages 291-302

  Somell, A ^a,b   Weitzberg, E ^a   Suneson, A ^c   Sollevi, A ^a,b   Hjelmqvist, H ^a,b,c  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH DEFENCE RESEARCH AGENCY   (Sweden)

Author keywords

Dextran; Endothelin; Endotoxin; Hypertonic saline; Sepsis; Shock; Tezosentan

Indexed keywords

DEXTRAN; ENDOTHELIN RECEPTOR ANTAGONIST; ESCHERICHIA COLI ENDOTOXIN; SODIUM CHLORIDE; TEZOSENTAN;

ANESTHESIA INDUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL OXYGEN TENSION; ARTERY CATHETERIZATION; ARTICLE; BLOOD GAS ANALYSIS; BOLUS INJECTION; CARDIOPULMONARY HEMODYNAMICS; CAROTID ARTERY; CONTINUOUS INFUSION; CONTROLLED STUDY; ENDOTOXEMIA; FEMALE; HEART INDEX; LUNG ARTERY PRESSURE; LUNG GAS EXCHANGE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SEPTIC SHOCK; SURVIVAL RATE; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE;

ACID-BASE EQUILIBRIUM; ACIDOSIS; ANIMALS; BLOOD CIRCULATION; BLOOD PRESSURE; DEXTRANS; DRUG THERAPY, COMBINATION; ENDOTOXINS; ESCHERICHIA COLI; FEMALE; HYPOTENSION; MALE; PULMONARY GAS EXCHANGE; PYRIDINES; RANDOM ALLOCATION; RECEPTORS, ENDOTHELIN; SALINE SOLUTION, HYPERTONIC; SHOCK, SEPTIC; SWINE; TETRAZOLES; VASODILATION;

EID: 34447305776     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2007.01703.x     Document Type: Article

References (57)

1. Angle, N., Hoyt, D., Coimbra, R. et al. 1998. Hypertonic saline resuscitation diminishes lung injury by suppressing neutrophil activation after hemorrhagic shock. Shock 9, 164 170.
2. Awane-Igata, Y., Ikeda, S. Watanabe, T. 1997. Inhibitory effects of TAK-044 on endothelin induced vasoconstriction in various canine arteries and porcine coronary arteries: a comparison with selective ETA and ETB receptor antagonists. Br J Pharmacol 120, 516 522.
3. Battistini, B., Forget, M. Laight, D. 1996. Potential roles for endothelins in systemic inflammatory response syndrome with a particular relation to cytokines. Shock 5, 167 183.
4. Ben-Haim, S., Edoute, Y., Hayam, G. Better, O. 1992. Sodium modulates inotropic response to hyperosmolarity in isolated working rat heart. Am J Physiol 263, 1154 1160.
5. Chen, S., Chen, Y., Meng, Q., Durand, J., Dicarlo, V. Oparil, S. 1995. Endothelin-receptor antagonist bosentan prevents and reverses hypoxic pulmonary hypertension in rats. J Appl Physiol 79, 2122 2131.
6. Chin, A., Radhakrishnan, J., Fornell, L. John, E. 2002. Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock. J Pediatr Surg 37, 482 487.
7. Ciesla, D., Moore, E., Gonzales, R., Biffl, W. Silliman, C. 2000. Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signalling. Shock 14, 265 269.
8. Clozel, M., Ramuz, H., Clozel, J. et al. 1999. Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 290, 840 846.
9. Filep, J., Sirois, M., Foldes-Filep, E. et al. 1993. Enhancement by endothelin-1 of microvascular permeability via the activation of ETA receptors. Br J Pharmacol 109, 880 886.
10. Fitzgerald, R., Oishi, P., Ovadia, B. et al. 2004. Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension. Pediatr Crit Care Med 5, 571 577.
11. Fitzmaurice, G. 2004. Modelling the mean: parametric curves. In : G. Fitzmaurice, N. Laird J. Ware (eds) Applied Longitudinal Analysis, pp. 141 147. John Wiley & Sons, Hoboken, NJ.
12. Gardiner, S., Kemp, P., March, J. Bennet, T. 1995. Enhancement of the hypotensive and vasodilator effects of endotoxemia in conscious rats by the endothelin antagonist, SB 209670. Br J Pharmacol 116, 1718 1719.
13. Geiger, R., Pajk, W., Neu, N. et al. 2006. Tezosentan decreases pulmonary artery pressure and improves survival rate in an animal model of meconium aspiration. Pediatr Res 59, 147 150.
14. Haynes, W. Webb, D. 1994. Contribution of endogenous generation of endothelin-1 to basal vascular tone. Lancet 344, 852 854.
15. Helset, E., Ytrehus, K., Tveita, T., Kjaeve, J. Jorgensen, L. 1994. Endothelin-1 causes accumulation of leukocytes in the pulmonary circulation. Circ Shock 44, 201 209.
16. Hemsen, A. 1991. Biochemical and functional characterization of endothelin peptides with special reference to vascular effects. Acta Physiol Scand Suppl 142, 1 61.
17. Ing, R., Nazeeri, M., Zeldes, S., Dulchavsky, S. Diebel, L. 1994. Hypertonic saline/dextran improves septic myocardial performance. Am Surg 60, 505 507.
18. Ishikawa, T., Yanagisawa, M., Kimura, S., Goto, K. Masaki, T. 1988a. Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide. Pfluegers Arch 413, 108 110.
19. Ishikawa, T., Yanagisawa, M., Kimura, S., Goto, K. Masaki, T. 1988b. Positive inotropic actions of novel vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 255, 970 973.
20. Ishimaru, S., Shichiri, M., Mineshita, S. Hirata, Y. 2001. Role of endothelin-1/endothelin receptor system in endotoxic shock rats. Hypertens Res 24, 119 126.
21. Ishizuka, T., Takamizawa-Matsumoto, M., Suzuki, K. Kurita, A. 1999. Endothelin-1 enhances vascular cell adhesion molecule-1 expression in tumor necrosis factor-α-stimulated vascular endothelial cells. Eur J Pharmacol 369, 237 245.
22. Junger, W., Coimbra, R., Liu, F. et al. 1997. Hypertonic saline resuscitation: a tool to modulate immune function in trauma patients Shock 8, 235 241.
23. Junger, W., Hoyt, D., Davis, R. et al. 1998. Hypertonicity regulates the function of human neutrophils by modulating chemoattractant receptor signalling and activating mitogen-activated protein kinase p38. J Clin Invest 101, 2768 2779.
24. Kaszaki, J., Wolfard, A., Boros, M., Baranyi, L., Okada, H. Nagy, S. 1997. Effects of antiendothelin treatment on the early hemodynamic changes in hyperdynamic endotoxemia. Acta Chir Hung 36, 152 153.
25. Kiely, D., Cargill, R., Struthers, A. Lipworth, B. 1997. Cardiopulmonary effects of endothelin-1 in man. Cardiovasc Res 33, 378 386.
26. Konrad, D. 2006. Cardiac function in experimental septic and non-septic conditions with special reference to the endothelin system. Thesis for Doctoral Degree (PhD), Karolinska Institutet.
27. Konrad, D., Oldner, A., Rossi, P., Wanecek, M., Rudehill, A. Weitzberg, E. 2004. Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock. Crit Care Med 32, 1192 1199.
28. Kreimeier, U., Frey, L., Dentz, J., Herbel, T. Messmer, K. 1991. Hypertonic saline dextran resuscitation during the initial phase of acute endotoxemia: effect on the regional blood flow. Crit Care Med 19, 801 809.
29. Kuklin, V., Kirov, M., Evgenov, O. et al. 2004. Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep. Crit Care Med 32, 766 773.
30. Kuklin, V., Kirov, M., Sovershaev, M. et al. 2005a. Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. Crit Care 9, 211 217.
31. Kuklin, V., Sovershaev, M., Andreasen, T., Skogen, V., Ytrehus, K. Bjertnaes, L. 2005b. Tezosentan reduces the microvascular filtration coefficient in isolated lungs from rats subjected to cecum ligation and puncture. Crit Care 9, 677 686.
32. Leeper Woodford, S., Carey, P., Byrne, K. et al. 1991. Ibuprofen attenuates plasma tumor necrosis factor activity during sepsis-induced acute lung injury. J Appl Physiol 71, 915 923.
33. Lipcsey, M., Larsson, A., Eriksson, M. Sjölin, J. 2006. Inflammatory, coagulatory and circulatory responses to logarithmic increases in the endotoxin dose in the anaesthetised pig. J Endotoxin Res 12, 99 112.
34. Lopez Farre, A., Riesco, A., Espinosa, G. et al. 1993. Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart. Circulation 88, 1166 1171.
35. Merkus, D., Houweling, B., Mirza, A., Boomsma, F., den Meiracker, A. Duncker, D. 2003. Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation. Cardiovasc Res 59, 745 754.
36. Modesti, P., Vanni, S., Paniccia, R. et al. 1999. Endothelin receptors in adult human and swine isolated ventricular cardiomyocytes. Biochem Pharmacol 58, 369 374.
37. Molenaar, P., O'Reilly, G., Sharkey, A. et al. 1993. Characterization and localization of endothelin receptor subtypes in the human atrioventricular conducting system and myocardium. Circ Res 72, 526 538.
38. Oi, Y., Åneman, A., Svensson, M., Ewert, S., Dahlqvist, M. Haljamae, H. 2000. Hypertonic saline-dextran improves intestinal perfusion and survival in porcine endotoxin shock. Crit Care Med 28, 2843 2850.
39. Oldner, A., Wanecek, M., Goiny, M. et al. 1998. The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock. Gut 42, 696 702.
40. Parker, S. Watkins, P. 2001. Experimental models of gram-negative sepsis. Br J Surg 88, 22 30.
41. Pernow, J., Hemsen, A. Lundberg, J. 1989. Increased plasma levels of endothelin-like immunoreactivity during endotoxin administration in the pig. Acta Physiol Scand 137, 317 318.
42. Pittet, J., Morel, D., Hemsen, A., Gunning, K., Lacroix, J.S., Suter, P. et al. 1991. Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 213, 261 264.
43. Poli-de-Figueiredo, L., Cruz, R., Jr., Sannomiya, P. Rocha-e-Silva, M. 2006. Mechanisms of action of hypertonic saline resuscitation in severe sepsis and septic shock. Endocr Metab Immune Disord Drug Targets 6, 201 206.
44. Rossi, P., Wanecek, M., Konrad, D. Oldner, A. 2004. Tezosentan counteracts endotoxin-induced pulmonary edema and improves gas exchange. Shock 21, 543 548.
45. Rubanyi, G. Polokoff, M. 1994. Endothelins: molecular biology, biochemistry, pharmacology, physiology and pathophysiology. Pharmacol Rev 46, 325 415.
46. Ruetten, H., Thiemermann, C. Vane, J.R. 1996. Effect of the endothelin receptor antagonist, SB 209670, on circulatory failure and organ injury in endotoxic shock in the anaesthetized rat. Br J Pharmacol 118, 198 204.
47. Sakai, S., Miyauchi, T., Kobayashi, M., Yamaguchi, I., Goto, K. Sugishita, Y. 1996. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature 384, 353 355.
48. Sanz, M., Johnston, B., Issekutz, A. Kubes, P. 1999. Endothelin-1 causes P-selectin-dependent leukocyte rolling and adhesion within rat mesenteric microvessels. Am J Physiol 277, 1823 1830.
49. Schalcher, C., Cotter, G., Reisin, L. et al. 2001. The dual endothelin receptor antagonist tezosentan acutely improves hemodynamic parameters in patients with advanced heart failure. Am Heart J 142, 340 349.
50. Seo, B., Oemar, B., Siebenmann, R., von Segesser, L. Lüscher, T. 1994. Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels. Circulation 89, 1203 1208.
51. Somell, A., Sollevi, A., Suneson, A., Riddez, L. Hjelmqvist, H. 2005. Beneficial effects of hypertonic saline/dextran on early survival in porcine endotoxin shock. Acta Anaesthesiol Scand 49, 1124 1134.
52. Torre-Amione, G., Young, J., Colucci, W. et al. 2003. Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol 42, 140 147.
53. Urbanowicz, W., Sogni, P., Moreau, R. et al. 2004. Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats. Gut 53, 1844 1849.
54. Wanecek, M., Oldner, A., Rudehill, A., Sollevi, A., Alving, K. Weitzberg, E. 1997. Cardiopulmonary dysfunction during porcine endotoxin shock is effectively counteracted by the endothelin receptor antagonist bosentan. Shock 7, 364 370.
55. Wanecek, M., Oldner, A., Rudehill, A., Sollevi, A., Alving, K. Weitzberg, E. 1999. EndothelinA-receptor antagonism attenuates pulmonary hypertension in porcine endotoxin shock. Eur Respir J 13, 145 151.
56. Wanecek, M., Weitzberg, E., Rudehill, A. Oldner, A. 2000. The endothelin system in septic and endotoxin shock. Eur J Pharmacol 407, 1 15.
57. Weitzberg, E., Lundberg, J. Rudehill, A. 1991. Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ Shock 33, 222 227.