Tezosentan, a combined parenteral endothelin receptor antagonist, produces pulmonary vasodilation in lambs with acute and chronic pulmonary hypertension

Pediatric Critical Care Medicine

Volumn 5, Issue 6, 2004, Pages 571-577

  Fitzgerald, Robert K ^a   Oishi, Peter ^a   Ovadia, Boaz ^a   Ross, Gregory A ^a   Reinhartz, Olaf ^a   Johengen, Michael J ^a   Fineman, Jeffrey R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endothelin; Endothelin Receptors; Pulmonary Circulation; Pulmonary Hypertension; Tezosentan; Vascular Endothelium

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN 1, ALA(1,3,11,15); ENDOTHELIN 1, ALA(1,3,11,15)-; ENDOTHELIN RECEPTOR; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE; TEZOSENTAN; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ACUTE DISEASE; ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; CHRONIC DISEASE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INTRAARTERIAL DRUG ADMINISTRATION; LUNG CIRCULATION; NEWBORN; PATHOPHYSIOLOGY; PULMONARY HYPERTENSION; RANDOMIZATION; SHEEP; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACUTE DISEASE; ANIMALS; ANIMALS, NEWBORN; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; ENDOTHELINS; HYPERTENSION, PULMONARY; INJECTIONS, INTRA-ARTERIAL; PULMONARY CIRCULATION; PYRIDINES; RANDOM ALLOCATION; RECEPTORS, ENDOTHELIN; SHEEP; TETRAZOLES; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 21644467908     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/01.PCC.0000137357.52609.F0     Document Type: Article

References (37)

1. Morin FC III, Stenmark KR: Persistent pulmonary hypertension of the newborn. Am J Respir Crit Care Med 1995; 151:2010-2032
2. Hoffman JIE, Rudolph AM, Heymann MA: Pulmonary vascular disease with congenital heart lesions: Pathologic features and causes. Circulation 1981; 64:873-877
3. Burrows FA, Klinck JR, Rabinovitch M, et al: Pulmonary hypertension in children: Perioperative management. Can Anaesth Soc J 1986; 33:606-628
4. Komai H, Haworth SG: The effect of cardiopulmonary bypass on the lung. In: Cardiopulmonary Bypass in Neonates, Infants, and Young Children. Jonas RA, Elliott MJ (Eds). Oxford, UK, Butterworth Heinemann, 1994, pp 242-262
5. Runo JR, Loyd JE: Primary pulmonary hypertension. Lancet 2003; 361:1533-1544
6. Rabinovitch M, Bothwell T, Hayakawa BN, et al: Pulmonary artery endothelial abnormalities in patients with congenital heart defects and pulmonary hypertension. Lab Invest 1986; 6:632-653
7. Giaid A, Yanagisawa M, Langleben D, et al: Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med 328:1732-1739
8. Faymonville ME, Deby-Dupont G, Larbuisson R, et al: Prostaglandin E2, prostacyclin, and thromboxane changes during nonpulsatile cardiopulmonary bypass in humans. J Thorac Cardiovasc Surg 1986; 91:858-866
9. Anyanwu E, Dittrich H, Gieseking R, et al: Ultrastructural changes in the human lung following cardiopulmonary bypass. Basic Res Cardiol 1982; 77:309-322
10. Yanagisawa M, Kurihara H, Kimura S, et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1998; 332:411-415
11. Hassoun PM, Thappa V, Landman MJ, et al: Endothelin 1: Mitogenic activity on pulmonary artery smooth muscle cells and release from hypoxic endothelial cells. Proc Exp Biol Med 1992; 199:165-170
12. Arai H, Hori S, Aramori I, et al: Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990; 348:730-732
13. Sakurai T, Yanagisawa M, Takuwa Y, et al: Cloning of a cDNA encoding a non-isopeptide- selective subtype of the endothelin receptor. Nature 1990; 348:732-735
14. Shetty SS, Toshikazu O, Webb RL, et al: Functionally distinct endothelin b receptors in vascular endothelium and smooth muscle. Biochem Biophys Res Commun 1993; 191: 459-464
15. Donahue DM, Lee ME, Suen HC, et al: Pulmonary hypoxia increases endothelin-1 gene expression in sheep. J Surg Res 1994; 57: 280-283
16. Miyauchi T, Yorikane R, Sakai S, et al: Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res 1993; 73: 887-897
17. Wong J, Reddy VM, Hendricks-Munoz K, et al: Endothelin-1 vasoactive responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol 1995; 269:H1965-H1972
18. Allen SW, Chatfield BA, Koppenhafer SA, et al: Circulating immunoreactive endothelin-1 in children with pulmonary hypertension. Association with acute hypoxic pulmonary vasoreactivity. Am Rev Respir Dis 1993; 148: 519-522
19. Vincent JA, Ross RD, Kassab J, et al: Relation of elevated plasma endothelin in congenital heart disease to increased pulmonary blood flow. Am J Cardiol 1993; 71:1204-1207
20. Komai H, Adatia IT, Elliot MJ, et al: Increased plasma levels of endothelin-1 after cardiopulmonary bypass in patients with pulmonary hypertension and congenital heart disease. J Thorac Cardiovasc Surg 1993; 106: 473-478
21. Reddy VM, Hendricks-Munoz KD, Rajasinghe HA, et al: Post-cardiopulmonary bypass pulmonary hypertension in lambs with increased pulmonary blood flow: A role for endothelin-1. Circulation 1997; 95: 1054-1061
22. Rubin LJ, Badesch DB, Barst RJ, et al: Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 2002; 346:896-903
23. Clozel M, Ramuz H, Clozel J-P, et al: Pharmacology of Tezosentan, new endothelin receptor antagonist designed for parental use. J Pharmacol Exp Ther 1999; 290:840-846
24. Chin A, Radhakrishnan J, Fornell L, et al: Effects of Tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets. J Pediatr Surg 2001; 36:1824-1828
25. Wilhelm SM, Stowe NT, Robinson AV, et al: The use of the endothelin receptor antagonist, tezosentan, before and after renal ischemia protects renal function. Transplantation 2001; 71:211-216
26. Torre-Amione G, Young JB, Colucci WS, et al: Hemodynamic and clinical effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients hospitalized for acute decompensated heart failure. J Am Coll Cardiol 2003; 42:140-147
27. Michael JR, Markewitz BA: Endothelins and the lung. Am J Respir Crit Care Med 1996; 154:555-581
28. Cassin, S, Kristova V, Davis T, et al: Tonedependent responses to endothelin in isolated perfused fetal sheep pulmonary circulation in situ. J Appl Physiol 1991; 70: 1228-1234
29. Rudolph AM, Kurland MD, Auld PAM, et al: Effects of vasodilator drugs on normal and serotonin-constricted pulmonary vessels of the dog. Am J Physiol 1959; 197:617-623
30. Vila JM, Medina P, Segarra G, et al: Endothelin- 1-induced potentiation of adrenergic responses in the rabbit pulmonary artery: Role of thromboxane A(2). Eur J Pharmacol 2001; 413:247-254
31. Yamamoto S, Burman HP, O'Donnell CP, et al: Endothelin causes portal and pulmonary hypertension in porcine endotoxemic shock. Am J Physiol. 1997; 272: H1239-H1249
32. Reddy VM, Meyrick B, Wong J, et al: In utero placement of aortopulmonary shunts: A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation 1995; 92:606-613
33. Black SM, Bekker J, Johengen M, et al: Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 2000; 47:97-106
34. Ovadia B, Reinhartz O, Fitzgerald R, et al: Alterations in ET-1, not nitric oxide, in oneweek- old lambs with congenital heart disease and increased pulmonary blood flow. Am J Physiol 2003; 284:H480-H490
35. O'Connor CM, Gattis WA, Adams KF Jr, et al: Tezosentan in patients with acute heart failure and acute coronary syndromes. J Am Coll Cardiol 2003; 41:1452-1457
36. Wong J, Vanderford PA, Fineman JR, et al: Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb. Am J Physiol 1993; 265:H1318-H1325
37. Wong J, Vanderford PA, Winters J, et al: Endothelin b receptor agonists produce pulmonary vasodilation in the intact newborn lamb with pulmonary hypertension. J Cardiovasc Pharmacol 1995; 25: 207-215