Novel endothelin receptor antagonist attenuates endotoxin-induced lung injury in sheep

Critical Care Medicine

Volumn 32, Issue 3, 2004, Pages 766-773

  Kuklin, Vladimir N ^a   Kirov, Mikhail Y ^a   Evgenov, Oleg V ^a   Sovershaev, Mikhail A ^a   Sjöberg, Jonas ^a   Kirova, Svetlana S ^a   Bjertnaes, Lars J ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Acute lung injury; Endothelin receptor antagonist; Endothelin 1; Endotoxin; Extravascular lung water; Pulmonary hemodynamics; Sheep; Tezosentan

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; ENDOTOXIN; RINGER LACTATE SOLUTION; TEZOSENTAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; ESCHERICHIA COLI; HEART INDEX; HEART STROKE VOLUME; HEMODYNAMICS; HYPOXEMIA; LUNG EDEMA; LUNG EXTRAVASCULAR FLUID; LUNG INJURY; LUNG VASCULAR RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZATION; SHEEP; SYSTEMIC VASCULAR RESISTANCE; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRAVASCULAR LUNG WATER; HEMODYNAMIC PROCESSES; LIPOPOLYSACCHARIDES; PROSPECTIVE STUDIES; PYRIDINES; RANDOM ALLOCATION; RECEPTORS, ENDOTHELIN; RESPIRATORY DISTRESS SYNDROME, ADULT; SHEEP; TETRAZOLES; VASODILATOR AGENTS;

EID: 1542509848     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000114575.08269.F6     Document Type: Article

References (35)

1. Bone RC: The pathogenesis of sepsis. Ann Intern Med 1991; 115:457-469
2. Sugiura M, Inagami T, Kon V: Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay. Biochem Biophys Res Commun 1989; 161: 1220-1227
3. Nakamura T, Kasai K, Sekiguchi Y, et al: Elevation of plasma endothelin concentrations during endotoxin shock in dogs. Eur J Pharmacol 1991; 205:277-282
4. Yanagisawa M, Kurihara H, Kimura S, et al: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988; 332:411-415
5. Pernow J, Hemsen A, Lundberg JM: Tissue specific distribution, clearance and vascular effects of endothelin in the pig. Biochem Biophys Res Commun 1989; 161: 647-653
6. Filep JG: Endothelin peptides: Biological actions and pathophysiological significance in the lung. Life Sci 1993; 52:119-133
7. Langleben D, DeMarchie M, Laporta D, et al: Endothelin-1 in acute lung injury and the adult respiratory distress syndrome. Am Rev Respir Dis 1993; 148:1646-1650
8. Mitaka C, Hirata Y, Makita K, et al: Endothelin-1 and atrial natriuretic peptide in septic shock. Am Heart J 1993; 126:466-468
9. Tschaikowsky K, Sagner S, Lehnert N, et al: Endothelin in septic patients: Effects on cardiovascular and renal function and its relationship to proinflammatory cytokines. Crit Care Med 2000; 28:1854-1860
10. Schmeck J, Konrad C, Schoffel S, et al: Interaction of acetylcholine and endothelin-1 in the modulation of pulmonary arterial pressure. Crit Care Med 2000; 28: 3869-3875
11. Wanecek M, Weitzberg E, Rudehill A, et al: The endothelin system in septic and endotoxin shock. Eur J Pharmacol 2000; 407: 1-15
12. Helset E, Kjaeve J, Hauge A: Endothelin-1-induced increases in microvascular permeability in isolated, perfused rat lungs requires leukocytes and plasma. Circ Shock 1993; 39: 15-20
13. Hele DJ, Birrell MA, Webber SE, et al: Effect of endothelin antagonists, including the novel ET(A) receptor antagonist LBL 031, on endothelin-1 and lipopolysaccharide-induced microvascular leakage in rat airways. Br J Pharmacol 2000; 131:1129-1134
14. Weitzberg E, Hemsen A, Rudehill A, et al: Bosentan-improved cardiopulmonary vascular performance and increased plasma levels of endothelin-1 in porcine endotoxin shock. Br J Pharmacol 1996; 118:617-626
15. Wanecek M, Rudehill A, Hemsen A, et al: The endothelin receptor antagonist, bosentan, in combination with the cyclooxygenase inhibitor, diclofenac, counteracts pulmonary hypertension in porcine endotoxin shock. Crit Care Med 1997; 25:848-857
16. Wanecek M, Weitzberg E, Alving K, et al: Effects of the endothelin receptor antagonist bosentan on cardiac performance during porcine endotoxin shock. Acta Anaesthesiol Scand 2001; 45:1262-1270
17. Clozel M, Ramuz H, Clozel JP, et al: Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use. J Pharmacol Exp Ther 1999; 290: 840-846
18. Dingemanse J, Clozel M, van Giersbergen PL: Entry-into-humans study with tezosentan, an intravenous dual endothelin receptor antagonist. J Cardiovasc Pharmacol 2002; 39: 795-802
19. Torre-Amione G, Young JB, Durand J, et al: Hemodynamic effects of tezosentan, an intravenous dual endothelin receptor antagonist, in patients with class III to IV congestive heart failure. Circulation 2001; 20:103: 973-980
20. Chin A, Radhakrishnan J, Fornell L, et al: Effects of tezosentan, a dual endothelin receptor antagonist, on the cardiovascular and renal systems of neonatal piglets during endotoxic shock. J Pediatr Surg 2002; 37: 482-487
21. Evgenov OV, Evgenov NV, Mollnes TE, et al: Methylene blue reduces pulmonary oedema and cyclo-oxygenase products in endotoxaemic sheep. Eur Respir J 2002; 20: 957-964
22. Zhou ZH, Sun B, Lin K, et al: Prevention of rabbit acute lung injury by surfactant, inhaled nitric oxide, and pressure support ventilation. Am J Respir Crit Care Med 2000; 161:581-588
23. Nakazawa H, Noda H, Noshima S, et al: Pulmonary transvascular fluid flux and cardiovascular function in sheep with chronic secsis. J Appl Physiol 1993; 75:2521-2528
24. Perkowski SZ, Sloane PJ, Spath JA Jr, et al: TNF-alpha and the pathophysiology of endotoxin-induced acute respiratory failure in sheep. J Appl Physiol 1996; 80:564-573
25. Morel DR, Pittet JF, Gunning K, et al: Time course of plasma and pulmonary lymph endothelin-like immunoreactivity during sustained endotoxaemia in chronically instrumented sheep. Clin Sci 1991; 81: 357-365
26. Pittet JF, Morel DR, Hemsen A, et al: Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 1991; 213: 261-264
27. Oldner A, Wanecek M, Goiny M, et al: The endothelin receptor antagonist bosentan restores gut delivery and reverses mucosal acidosis in porcine endotoxin shock. Gut 1998; 42:696-702
28. Iskit AB, Sungur A, Gedikoglu G, et al: The effects of bosentan, aminoguanidine and L-canavanine on mesenteric blood flow, spleen and liver in endotoxemic mice. Eur J Pharmacol 1999; 379:73-80
29. Malmstrom RE, Bjorne H, Oldner A, et al: Intestinal nitric oxide in the normal and endotoxemic pig. Shock 2002; 18:456-460
30. Ivy DD, Parker TA, Kinsella JP, et al: Endothelin A receptor blockade decreases pulmonary vascular resistance in premature lambs with hyaline membrane disease. Pediatr Res 1998; 44:175-180
31. Albertini M, Ciminaghi B, Mazzola S, et al: Improvement of respiratory function by bosentan during endotoxic shock in the pig. Prostaglandins Leukot Essent Fatty Acids 2001; 65:103-138
32. Kaisers U, Busch T, Wolf S, et al: Inhaled endothelin A antagonist improves arterial oxygenation in experimental acute lung injury. Intensive Care Med 2000; 26: 1334-1342
33. Deja M, Wolf S, Busch T, et al: The inhaled ET(A) receptor antagonist LU-135252 acts as a selective pulmonary vasodilator. Clin Sci 2002; 103:48:218-248
34. Miyauchi T, Masaki T: Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol 1999; 61:391-415
35. Barnard JW, Barman SA, Adkins WK, et al: Sustained effects of endothelin-1 on rabbit, dog, and rat pulmonary circulations. Am J Physiol 1991; 261:H479-H486