Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract

Biochemical Pharmacology

Volumn 74, Issue 4, 2007, Pages 647-658

  Teixeira, Cleber E ^a,b   Jin, Liming ^b   Priviero, Fernanda B M ^b   Ying, Zhekang ^b   Webb, R Clinton ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Detrusor; Rho kinase; RhoA; RhoGEFs; Trigone; Urethra

Indexed keywords

2 METHYL 1 [(4 METHYL 5 ISOQUINOLINYL)SULFONYL]HOMOPIPERAZINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; CALCIUM; CARBACHOL; ENDOTHELIN 1; FASUDIL; H 1152; ISOQUINOLINE DERIVATIVE; PHENYLEPHRINE; POTASSIUM CHLORIDE; RHO KINASE ALPHA; RHO KINASE BETA; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BLADDER CONTRACTION; DETRUSOR MUSCLE; MALE; MUSCLE CONTRACTILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SENSITIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE TONE; URETHRA;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ADENOSINE TRIPHOSPHATE; AMIDES; ANIMALS; ATROPINE; BLOTTING, WESTERN; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENDOTHELIN-1; ENZYME INHIBITORS; GUANINE NUCLEOTIDE DISSOCIATION INHIBITORS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NIFEDIPINE; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOA GTP-BINDING PROTEIN; URETHRA; URINARY BLADDER;

EID: 34447284478     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.06.004     Document Type: Article

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