Pharmacological properties of A-204176, a novel and selective α1A adrenergic agonist, in in vitro and in vivo models of urethral function

Life Sciences

Volumn 70, Issue 2, 2001, Pages 181-197

  O'Neill, Alyssa B ^a,b   Buckner, Steven A ^a   Brune, Michael E ^a   Milicic, Ivan ^a   Daza, Anthony V ^a   Gauvin, Donna M ^a   Altenbach, Robert J ^a   Meyer, Michael D ^a   Williams, Michael ^a   Sullivan, James P ^a   Brioni, Jorge D ^a  

^a ABBOTT LABORATORIES   (United States)

^b Dept 48Q ^*  (United States)

Author keywords

A 204176; Adrenergic 1 agonists; Arterial blood pressure; Intraurethral pressure; Leak point pressure; Phenylpropanolamine; Urethral pressure profilometry

Indexed keywords

A 204176; ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR; N [5 (1H IMIDAZOL 4 YL) 5,6,7,8 TETRAHYDRO 1 NAPHTHALENYL]METHANESULFONAMIDE; PHENYLEPHRINE; PHENYLPROPANOLAMINE; PRAZOSIN; UNCLASSIFIED DRUG;

ABDOMINAL PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOG; DRUG BINDING; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MUSCLE TONE; NONHUMAN; RABBIT; RAT; SPLEEN; URETHRA; URETHRA PRESSURE; URINE INCONTINENCE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; AORTA; BLOOD PRESSURE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; IMIDAZOLES; INJECTIONS, INTRAVENOUS; ISOMETRIC CONTRACTION; MALE; MUSCLE, SMOOTH; PHENYLPROPANOLAMINE; PRAZOSIN; PRESSURE; RABBITS; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; TETRAHYDRONAPHTHALENES; URETHRA; URINARY CATHETERIZATION; URODYNAMICS;

CANIS FAMILIARIS; ORYCTOLAGUS CUNICULUS;

EID: 0035976853     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01388-1     Document Type: Article

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