Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis

Biochemical and Biophysical Research Communications

Volumn 360, Issue 2, 2007, Pages 327-332

  Zhang, Keying ^a   Shang, Yingli ^a   Liao, Shangying ^a   Zhang, Wei ^a   Nian, Hong ^a   Liu, Yixun ^a   Chen, Quan ^a   Han, Chunsheng ^a  

^a INSTITUTE OF ZOOLOGY   (China)

Author keywords

Apoptosis; Germ cell; Hyperthermia; ROS; Testis; UCP2

Indexed keywords

REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GERM CELL; HYPERTHERMIA; HYPERTHERMIC THERAPY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERMATID; THERMAL EXPOSURE;

ANIMALS; APOPTOSIS; CELLS, CULTURED; FEVER; ION CHANNELS; MALE; MICE; MITOCHONDRIAL PROTEINS; SPERMATOZOA; TESTIS;

EID: 34447100854     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.071     Document Type: Article

References (38)

1. Kormano M. Development of the rectum-testis temperature difference in the post-natal rat. Journal of Reproduction and Fertility 14 (1967) 427-437
2. Lue Y.H., Hikim A.P., Swerdloff R.S., Im P., Taing K.S., Bui T., Leung A., and Wang C. Single exposure to heat induces stage-specific germ cell apoptosis in rats: role of intratesticular testosterone on stage specificity. Endocrinology 140 (1999) 1709-1717
3. Xu J., Xu Z., Jiang Y., Qian X., and Huang Y. Cryptorchidism induces mouse testicular germ cell apoptosis and changes in bcl-2 and bax protein expression. Journal of Environmental Pathology, Toxicology and Oncology 19 (2000) 25-33
4. Vera Y., Diaz-Romero M., Rodriguez S., Lue Y., Wang C., Swerdloff R.S., and Sinha Hikim A.P. Mitochondria-dependent pathway is involved in heat-induced male germ cell death: lessons from mutant mice. Biology of Reproduction 70 (2004) 1534-1540
5. Green D.R., and Kroemer G. The pathophysiology of mitochondrial cell death. Science 305 (2004) 626-629
6. Du C., Fang M., Li Y., Li L., and Wang X. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102 (2000) 33-42
7. Orrenius S., Gogvadze V., and Zhivotovsky B. Mitochondrial oxidative stress: implications for cell death. Annual Review of Pharmacology and Toxicology 47 (2007) 143-183
8. Cadenas E., and Davies K.J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radical Biology & Medicine 29 (2000) 222-230
9. Adam-Vizi V., and Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends in Pharmacological Sciences 27 (2006) 639-645
10. Katschinski D.M., Boos K., Schindler S.G., and Fandrey J. Pivotal role of reactive oxygen species as intracellular mediators of hyperthermia-induced apoptosis. The Journal of Biological Chemistry 275 (2000) 21094-21098
11. Adams S.H. Uncoupling protein homologs: emerging views of physiological function. The Journal of Nutrition 130 (2000) 711-714
12. Ricquier D., and Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. The Biochemical Journal 345 Pt 2 (2000) 161-179
13. Fleury C., Neverova M., Collins S., Raimbault S., Champigny O., Levi-Meyrueis C., Bouillaud F., Seldin M.F., Surwit R.S., Ricquier D., and Warden C.H. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nature Genetics 15 (1997) 269-272
14. Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B.S., Miroux B., Couplan E., Alves-Guerra M.C., Goubern M., Surwit R., Bouillaud F., Richard D., Collins S., and Ricquier D. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nature Genetics 26 (2000) 435-439
15. Krauss S., Zhang C.Y., and Lowell B.B. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 118-122
16. Echtay K.S., Roussel D., St-Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., Harper J.A., Roebuck S.J., Morrison A., Pickering S., Clapham J.C., and Brand M.D. Superoxide activates mitochondrial uncoupling proteins. Nature 415 (2002) 96-99
17. Korshunov S.S., Skulachev V.P., and Starkov A.A. High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Letters 416 (1997) 15-18
18. Negre-Salvayre A., Hirtz C., Carrera G., Cazenave R., Troly M., Salvayre R., Penicaud L., and Casteilla L. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. The FASEB Journal 11 (1997) 809-815
19. Teshima Y., Akao M., Jones S.P., and Marban E. Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes. Circulation Research 93 (2003) 192-200
20. Kizaki T., Suzuki K., Hitomi Y., Taniguchi N., Saitoh D., Watanabe K., Onoe K., Day N.K., Good R.A., and Ohno H. Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proceedings of the National Academy of Sciences of the United States of America 99 (2002) 9392-9397
21. Lee K.U., Lee I.K., Han J., Song D.K., Kim Y.M., Song H.S., Kim H.S., Lee W.J., Koh E.H., Song K.H., Han S.M., Kim M.S., Park I.S., and Park J.Y. Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis. Circulation Research 96 (2005) 1200-1207
22. Blanc J., Alves-Guerra M.C., Esposito B., Rousset S., Gourdy P., Ricquier D., Tedgui A., Miroux B., and Mallat Z. Protective role of uncoupling protein 2 in atherosclerosis. Circulation 107 (2003) 388-390
23. Horimoto M., Fulop P., Derdak Z., Wands J.R., and Baffy G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology (Baltimore, Md.) 39 (2004) 386-392
24. Krauss S., Zhang C.Y., Scorrano L., Dalgaard L.T., St-Pierre J., Grey S.T., and Lowell B.B. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. The Journal of Clinical Investigation 112 (2003) 1831-1842
25. Diano S., Matthews R.T., Patrylo P., Yang L., Beal M.F., Barnstable C.J., and Horvath T.L. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology 144 (2003) 5014-5021
26. Mattiasson G., Shamloo M., Gido G., Mathi K., Tomasevic G., Yi S., Warden C.H., Castilho R.F., Melcher T., Gonzalez-Zulueta M., Nikolich K., and Wieloch T. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nature Medicine 9 (2003) 1062-1068
27. McLeod C.J., Aziz A., Hoyt Jr. R.F., McCoy Jr. J.P., and Sack M.N. Uncoupling proteins 2 and 3 function in concert to augment tolerance to cardiac ischemia. The Journal of Biological Chemistry 280 (2005) 33470-33476
28. de Bilbao F., Arsenijevic D., Vallet P., Hjelle O.P., Ottersen O.P., Bouras C., Raffin Y., Abou K., Langhans W., Collins S., Plamondon J., Alves-Guerra M.C., Haguenauer A., Garcia I., Richard D., Ricquier D., and Giannakopoulos P. Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. Journal of Neurochemistry 89 (2004) 1283-1292
29. Li Y.C., Hu X.Q., Xiao L.J., Hu Z.Y., Guo J., Zhang K.Y., Song X.X., and Liu Y.X. An oligonucleotide microarray study on gene expression profile in mouse testis of experimental cryptorchidism. Frontiers in Bioscience 11 (2006) 2465-2482
30. Draper H.H., and Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods in Enzymology 186 (1990) 421-431
31. Benzie I.F., and Strain J.J. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods in Enzymology 299 (1999) 15-27
32. Chandrasekaran Y., McKee C.M., Ye Y., and Richburg J.H. Influence of TRP53 status on FAS membrane localization, CFLAR (c-FLIP) ubiquitinylation, and sensitivity of GC-2spd (ts) cells to undergo FAS-mediated apoptosis. Biology of Reproduction 74 (2006) 560-568
33. Mills E.M., Xu D., Fergusson M.M., Combs C.A., Xu Y., and Finkel T. Regulation of cellular oncosis by uncoupling protein 2. The Journal of Biological Chemistry 277 (2002) 27385-27392
34. Ikeda M., Kodama H., Fukuda J., Shimizu Y., Murata M., Kumagai J., and Tanaka T. Role of radical oxygen species in rat testicular germ cell apoptosis induced by heat stress. Biology of Reproduction 61 (1999) 393-399
35. Hofmann M.C., Hess R.A., Goldberg E., and Millan J.L. Immortalized germ cells undergo meiosis in vitro. Proceedings of the National Academy of Sciences of the United States of America 91 (1994) 5533-5537
36. Criddle D.N., Gillies S., Baumgartner-Wilson H.K., Jaffar M., Chinje E.C., Passmore S., Chvanov M., Barrow S., Gerasimenko O.V., Tepikin A.V., Sutton R., and Petersen O.H. Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells. The Journal of Biological Chemistry 281 (2006) 40485-40492
37. Peltola V., Huhtaniemi I., and Ahotupa M. Antioxidant enzyme activity in the maturing rat testis. Journal of Andrology (1992) 450-455
38. Bauche F., Fouchard M.H., and Jegou B. Antioxidant system in rat testicular cells. FEBS Letters 349 (1994) 392-396