Connexins in the lens: Are they to blame in diabetic cataractogenesis?

Novartis Foundation Symposium

Volumn 219, Issue , 1999, Pages 97-112

  Kistler, Joerg ^a   Lin, Jun Sheng ^b   Bond, Jacqui ^a   Green, Colin ^b   Eckert, Reiner ^a   Merriman, Rachelle ^a   Tunstall, Mark ^a   Donaldson, Paul ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

GAP JUNCTION PROTEIN;

ANIMAL; CATARACT; CHANNEL GATING; DIABETES MELLITUS; LENS; PATHOLOGY; PHYSIOLOGY; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CATARACT; CONNEXINS; DIABETES COMPLICATIONS; ION CHANNEL GATING; LENS CORTEX, CRYSTALLINE;

EID: 0032616510     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (21)

1. Baldo GJ, Mathias RT 1992 Spatial variations in membrane properties in the intact rat lens. Biophys J 63:518-529
2. Beyer EC, Kistler J, Paul DL, Goodenough DA 1989 Antisera directed against connexin43 peptides react with a 43-kD protein localized to gap junctions in myocardium and other tissues. J Cell Biol 108:595-605
3. Bond J, Green C, Donaldson P, Kistler J 1996 Liquefaction of cortical tissue in diabetic and galactosemic rat lenses defined by confocal laser scanning microscopy. Invest Ophthalmol Vis Sci 37:1557-1565
4. Datiles M, Fukui H, Kuwabara T, Kinoshita JH 1982 Galactose cataract prevention with sorbinil, an aldose reductase inhibitor: a light microscopic study. Invest Ophthalmol Vis Sci 22:174-179
5. Donaldson PJ, Dong Y, Roos M, Green C, Goodenough DA, Kistler J 1995 Changes in lens connexin expression lead to increased gap junctional voltage dependence and conductance. Am J Physiol 269:C590-C600
6. Goodenough DA, Dick JSB, Lyons JE 1980 Lens metabolic cooperation: a study of mouse lens transport and permeability visualized with freeze-substitution autoradiography and electron microscopy. J Cell Biol 86:576-589
7. Grujters WTM, Kistler J, Bullivant S 1987 Formation, distribution and dissociation of intercellular junctions in the lens. J Cell Sci 88:351-359
8. Jiang JX, Goodenough DA 1996 Heteromeric connexons in lens gap junction channels. Proc Natl Acad Sci USA 93:1287-1291
9. Kuwabara T, Kinoshita JH, Cogan DG 1969 Electron microscopic study of galactose induce cataract. Invest Ophthalmol Vis Sci 8:133-149
10. Lee AYW, Ching SK, Chung SSM 1995 Demonstration that polyol accumulation is responsible for diabetic cataract by use of transgenic mice expressing the aldose reductase gene in the lens. Proc Natl Acad Sci USA 92:2780-2784
11. Lin JS 1997 Post-translational cleavage of lens connexin50 and its functional implications. PhD thesis, University of Auckland, Auckland, New Zealand
12. Lin JS, Fitzgerald S, Dong Y, Knight C, Donaldson P, Kistler J 1997 Processing of the gap junction protein connexin50 in the ocular lens is accomplished by calpain. Eur J Cell Biol 73:141-149
13. Liu SG, Taffet S, Stoner L, Delmar M, Vallano ML, Jalife J 1993 A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification. Biophys J 64:1422-1433
14. Mathias RT, Rae JL, Baldo GJ 1997 Physiological properties of the normal lens. Physiol Rev 77:21-50
15. Merriman-Smith R, Tunstall M, Kistler J, Donaldson P, Housley G, Eckert R 1998 Expression profiles of P2 receptor isoforms P2Y1 and P2Y2 in the rat lens. Invest Ophthalmol Vis Sci 39: in press
16. Mitton KP, Dean PAW, Dzialosynski T, Xiong H, Sanford SE, Trevithick JR 1993 Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. Exp Eye Res 56:187-198
17. Paul DL, Ebihara L, Takemoto LJ, Swenson KI, Goodenough DA 1991 Connexin46, a novel lens gap junction protein, induces voltage gated currents in nonjunctional plasma membrane of Xenopus oocytes. J Cell Biol 115:1077-1089
18. Prescott A, Duncan G, Van Marle J, Vrensen G 1994 A correlated study of metabolic cell communication and gap junction distribution in the adult frog lens. Exp Eye Res 58:737-746
19. Rae JL, Bartling C, Rae J, Mathias RT 1996 Dye transfer between cells of the lens. J Membr Biol 150:89-103
20. Robison WG, Houlder N, Kinoshita JH 1990 The role of lens epithelium in sugar cataract formation. Exp Eye Res 50:641-646
21. White TW, Bruzzone R, Goodenough DA, Paul DL 1992 Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70. Mol Biol Cell 3:711-720