Mathematical model of vertebrate gap junctions derived from electrical measurements on homotypic and heterotypic channels

Journal of Physiology

Volumn 510, Issue 1, 1998, Pages 177-189

  Vogel, Rolf ^a   Weingart, Robert ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

VOLTAGE GATED CHANNEL FORMING PROTEIN; GAP JUNCTION PROTEIN;

ARTICLE; CELL JUNCTION; CHANNEL GATING; MATHEMATICAL MODEL; MEMBRANE CHANNEL; MEMBRANE CONDUCTANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; TRANSPORT KINETICS; CONFORMATIONAL TRANSITION; ELECTRIC CONDUCTIVITY; GAP JUNCTION; HETEROTYPIC GAP JUNCTION CHANNEL; HOMOTYPIC GAP JUNCTION CHANNEL; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; PREDICTION; PROCESS DEVELOPMENT; PROCESS MODEL; PROTEIN DETERMINATION; PROTEIN FUNCTION;

ANIMALS; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GAP JUNCTIONS; HUMANS; ION CHANNELS; MODELS, BIOLOGICAL; VERTEBRATES;

EID: 0032126260     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.177bz.x     Document Type: Article

References (14)

1. BAIGENT, S., STARK, J. & WARNKR, A. (1997). Modelling the effect of gap junction nonlinearities in systems of coupled cells. Journal of Theoretical Biology 186, 223-239.
2. BANACH, K. & WEINGART, R. (1996). Connexin43 gap junctions exhibit asymmetrical gating properties. Pflügers Archiv 431, 775-785.
3. BRUZZONE, R., WHITE, T. W. & PAUL, D. L. (1996). Connections with connexins; the molecular basis of direct intercellular signalling. European Journal of Biochemistry 238, 1-27.
4. BUKAUSKAS, F. F., ELFGANG, C., WILLECKE, K. & WEINGART, R. (1995a). Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. Biophysical Journal 68, 2289-2298.
5. BUKAUSKAS, F. F., ELFGANG, C., WILLECKE, K. & WEINGART, R. (1995b). Heterotypic gap junction channels (connexin26-connexin32) violate the paradigm of unitary conductance. Pflügers Archiv 429, 870-872.
6. BUKAUSKAS, F. F., VOGEL, R. & WEINGART, R. (1997). Biophysical properties of heterotypic gap junctions newly formed between two types of insect cells. Journal of Physiology 499, 701-713.
7. BUKAUSKAS, F. F. & WEINGART, R. (1995). Gating properties of homo-and heterotypic gap junction channels formed by different mouse connexins. In Proceedings of the 1995 Gap Junction Conference, L'Ile des Embiez, France.
8. HARRIS, A. L., SPRAY, D. C. & BENNETT, M. V. L. (1981). Kinetic properties of a voltage-dependent junctional conductance. Journal of General Physiology 77, 95-117.
9. JOHNSTON, D. & Wu, S. M. (1995). Foundations of Cellular Neurophysiology, pp. 9-53 and 121-142. MIT Press, Cambridge, MA, USA.
10. TREXLER, E. B., BENNETT, M. V. L., BARGIELLO, T. A. & VERSELIS, V. K. (1996). Voltage gating and permeation in a gap junction hemichannel. Proceedings of the National Academy of Sciences of the USA 93, 5836-5841.
11. VALIUNAS, V., BUKAUSKAS, F. F. & WEINGART, R. (1997). Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells. Circulation Research 80, 708-719.
12. VALIUNAS, V. & WEINGART, R. (1997). Voltage gating and conductive properties of gap junction hemichannels studied in transfected HeLa cells. In Proceedings of the 1997 International Gap Junction Conference, Key Largo, FL, USA, p. 97.
13. WALTZMAN, M. N. & SPRAY, D. C. (1995). Exogenous expression of connexins for physiological characterisation of channel properties: Comparison of methods and results. In International Communication Through Gap Junctions: Progress in Cell Research, vol. 4, ed. KANNO, Y., KATAOKA, K., SHIBA, Y., SHIBATA, Y., SHIMAZU, T., pp. 9-17. Elsevier, Amsterdam.
14. WEINGART, R., BUKAUSKAS, F. F., VALIUNAS, V., VOGEL, R., WILLECKE, K. & ELFGANG, C. (1996). Heterotypic gap junctions and gating properties. In Proceedings of Keystone Conference: Molecular Aspects to the Function of Intercellular Junctions, p. 16.