메뉴 건너뛰기




Volumn 85, Issue 2, 2003, Pages 492-502

Iron toxicity in organotypic cultures of hippocampal slices: Role of reactive oxygen species

Author keywords

Apoptosis; Caspase; Cytochrome c; Iron; Reactive oxygen species; Toxicity

Indexed keywords

CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 9; CYTOCHROME C; FERROUS SULFATE; FLUORESCEIN; IRON; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

EID: 0345700749     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01708.x     Document Type: Article
Times cited : (53)

References (47)
  • 1
    • 0035337960 scopus 로고    scopus 로고
    • Asbestos causes apoptosis in alveolar epithelial cells: Role of iron-induced free radicals
    • Aljandali A., Pollack H., Yeldandi A., Li Y., Weitzman S. A. and Kamp D. W. (2001) Asbestos causes apoptosis in alveolar epithelial cells: role of iron-induced free radicals. J. Lab. Clin. Med. 137, 330-339.
    • (2001) J. Lab. Clin. Med. , vol.137 , pp. 330-339
    • Aljandali, A.1    Pollack, H.2    Yeldandi, A.3    Li, Y.4    Weitzman, S.A.5    Kamp, D.W.6
  • 2
    • 0027096062 scopus 로고
    • Oxidants are a major contributor to aging
    • Ames B. N. and Shigenaga M. K. (1992) Oxidants are a major contributor to aging. Ann. NYAcad. Sci. 663, 85-96.
    • (1992) Ann. NY Acad. Sci. , vol.663 , pp. 85-96
    • Ames, B.N.1    Shigenaga, M.K.2
  • 3
    • 0031911994 scopus 로고    scopus 로고
    • Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
    • Baker K., Marcus C. B., Huffman K., Kruk H., Malfroy B. and Doctrow S. R. (1998) Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215-221.
    • (1998) J. Pharmacol. Exp. Ther. , vol.284 , pp. 215-221
    • Baker, K.1    Marcus, C.B.2    Huffman, K.3    Kruk, H.4    Malfroy, B.5    Doctrow, S.R.6
  • 4
    • 0033512348 scopus 로고    scopus 로고
    • New perspectives on iron: An introduction
    • Boldt D. H. (1999) New perspectives on iron: an introduction. Am. J. Med. Sci. 318, 207-212.
    • (1999) Am. J. Med. Sci. , vol.318 , pp. 207-212
    • Boldt, D.H.1
  • 5
    • 0029866991 scopus 로고    scopus 로고
    • Beta-amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
    • Bruce A. J., Malfroy B. and Baudry M. (1996) beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc. Natl Acad. Sci. USA 93, 2312-2316.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 2312-2316
    • Bruce, A.J.1    Malfroy, B.2    Baudry, M.3
  • 6
    • 0032504574 scopus 로고    scopus 로고
    • Mitochondrial control of apoptosis: The role of cytochrome c
    • Cai J., Yang J. and Jones D. P. (1998) Mitochondrial control of apoptosis: the role of cytochrome c. Biochim. Biophys. Acta 1366, 139-149.
    • (1998) Biochim. Biophys. Acta , vol.1366 , pp. 139-149
    • Cai, J.1    Yang, J.2    Jones, D.P.3
  • 8
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra J., Samali A. and Orrenius S. (2000) Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 29, 323-333.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 9
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen G. M. (1997) Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.
    • (1997) Biochem. J. , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 10
    • 0000341879 scopus 로고
    • Free radicals, oxidative stress, and neurodegeneration
    • Calne D. B., ed. WB Saunders, Philadelphia
    • Cohen G. M. and Werner P. (1995) Free radicals, oxidative stress, and neurodegeneration. In: Neurodegenerative Diseases (Calne D. B., ed.), pp. 139-161. WB Saunders, Philadelphia.
    • (1995) Neurodegenerative Diseases , pp. 139-161
    • Cohen, G.M.1    Werner, P.2
  • 11
    • 0026513756 scopus 로고
    • A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains
    • Connor J. R., Menzies S. L., St Martin S. M. and Mufson E. J. (1992) A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31, 75-83.
    • (1992) J. Neurosci. Res. , vol.31 , pp. 75-83
    • Connor, J.R.1    Menzies, S.L.2    St Martin, S.M.3    Mufson, E.J.4
  • 12
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D. R. and Reed J. C. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 13
    • 0001796587 scopus 로고    scopus 로고
    • Oxidative stress, brain iron and neurodegeneration. Basic principles
    • Olanow C. W. and Youdium M., eds. Academic Press, London
    • Gutteridge J. M. C. and Halliwell B. (1996) Oxidative stress, brain iron and neurodegeneration. Basic principles. In: Neurodegeneration and Neuroprotection in Parkinson's Disease (Olanow C. W. and Youdium M., eds), pp. 1-21. Academic Press, London.
    • (1996) Neurodegeneration and Neuroprotection in Parkinson's Disease , pp. 1-21
    • Gutteridge, J.M.C.1    Halliwell, B.2
  • 14
    • 0027301060 scopus 로고
    • Lipid antioxidants in acute central nervous system injury
    • Hall E. D. (1993) Lipid antioxidants in acute central nervous system injury. Ann. Emerg. Med. 22, 1022-1027.
    • (1993) Ann. Emerg. Med. , vol.22 , pp. 1022-1027
    • Hall, E.D.1
  • 15
    • 0026754574 scopus 로고
    • Reactive oxygen species and the central nervous system
    • Halliwell B. (1992) Reactive oxygen species and the central nervous system. J. Neurochem. 59, 1609-1623.
    • (1992) J. Neurochem. , vol.59 , pp. 1609-1623
    • Halliwell, B.1
  • 16
    • 0026740508 scopus 로고
    • Biologically relevant metal ion-dependent hydroxyl radical generation. An update
    • Halliwell B. and Gutteridge J. M. (1992) Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Lett. 307, 108-112.
    • (1992) EBS Lett. , vol.307 , pp. 108-112
    • Halliwell, B.1    Gutteridge, J.M.2
  • 17
    • 0032783532 scopus 로고    scopus 로고
    • Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: Comparison with 2′,7′-dichloro dihydrofluorescein diacetate, 5 (and 6)-carboxy-2′,7′-dichloro dihydrofluorescein diacetate, and dihydrorhodamine 123
    • Hempel S. L., Buettner G. R., O'Malley Y. Q., Wessels D. A. and Flaherty D. M. (1999) Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichloro dihydrofluorescein diacetate, 5 (and 6)-carboxy-2′,7′-dichloro dihydrofluorescein diacetate, and dihydrorhodamine 123. Free Radic. Biol. Med. 27, 146-159.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 146-159
    • Hempel, S.L.1    Buettner, G.R.2    O'Malley, Y.Q.3    Wessels, D.A.4    Flaherty, D.M.5
  • 18
    • 0034305391 scopus 로고    scopus 로고
    • Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis
    • Jacob A. K., Hotchkiss R. S., Swanson P. E., Tinsley K. W., Karl I. E. and Buchman T. G. (2000) Injection of iron compounds followed by induction of the stress response causes tissue injury and apoptosis. Shock 14, 460-464.
    • (2000) Shock , vol.14 , pp. 460-464
    • Jacob, A.K.1    Hotchkiss, R.S.2    Swanson, P.E.3    Tinsley, K.W.4    Karl, I.E.5    Buchman, T.G.6
  • 19
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P. and Olanow C. W. (1998) Understanding cell death in Parkinson's disease. Ann. Neurol. 44, S72-S84.
    • (1998) Ann. Neurol. , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 20
    • 0032534623 scopus 로고    scopus 로고
    • Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons
    • Kaal E. C., Veldman H., Sodaar P., Joosten E. A. and Dop Bar P. R. (1998) Oxidant treatment causes a dose-dependent phenotype of apoptosis in cultured motoneurons. J. Neurosci. Res. 54, 778-786.
    • (1998) J. Neurosci. Res. , vol.54 , pp. 778-786
    • Kaal, E.C.1    Veldman, H.2    Sodaar, P.3    Joosten, E.A.4    Dop Bar, P.R.5
  • 21
    • 0034648298 scopus 로고    scopus 로고
    • The Haber-Weiss reaction and mechanisms of toxicity
    • Kehrer J. P. (2000) The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 149, 43-50.
    • (2000) Toxicology , vol.149 , pp. 43-50
    • Kehrer, J.P.1
  • 22
    • 0023221068 scopus 로고
    • Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
    • Koh J. Y. and Choi D. W. (1987) Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J. Neurosci. Methods 20, 83-90.
    • (1987) J. Neurosci. Methods , vol.20 , pp. 83-90
    • Koh, J.Y.1    Choi, D.W.2
  • 23
    • 0037101622 scopus 로고    scopus 로고
    • The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes
    • Kress G. J., Dineley K. E. and Reynolds I. J. (2002) The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes. J. Neurosci. 22, 5848-5855.
    • (2002) J. Neurosci. , vol.22 , pp. 5848-5855
    • Kress, G.J.1    Dineley, K.E.2    Reynolds, I.J.3
  • 24
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist M. and Jaattela M. (2001) Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol. 2, 589-598.
    • (2001) Nat. Rev. Mol. Cell. Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 25
    • 0033789565 scopus 로고    scopus 로고
    • Free radical pathways in CNS injury
    • Lewen A., Matz P. and Chan P. H. (2000) Free radical pathways in CNS injury. J. Neurotrauma 17, 871-890.
    • (2000) J. Neurotrauma , vol.17 , pp. 871-890
    • Lewen, A.1    Matz, P.2    Chan, P.H.3
  • 26
    • 0032619789 scopus 로고    scopus 로고
    • The mechanism of 'Fenton-like' reactions and their importance for biological systems. A biologist's view
    • Liochev S. I. (1999) The mechanism of 'Fenton-like' reactions and their importance for biological systems. A biologist's view. Met. Ions Biol. Syst. 36, 1-39.
    • (1999) Met. Ions Biol. Syst. , vol.36 , pp. 1-39
    • Liochev, S.I.1
  • 27
    • 0035205515 scopus 로고    scopus 로고
    • Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures
    • Liu W., Liu R., Schreiber S. S. and Baudry M. (2001a) Role of polyamine metabolism in kainic acid excitotoxicity in organotypic hippocampal slice cultures. J. Neurochem. 79, 976-984.
    • (2001) J. Neurochem. , vol.79 , pp. 976-984
    • Liu, W.1    Liu, R.2    Schreiber, S.S.3    Baudry, M.4
  • 28
    • 0035914173 scopus 로고    scopus 로고
    • Kainate excitotoxicity in organotypic hippocampal slice cultures: Evidence for multiple apoptotic pathways
    • Liu W., Liu R., Chun J. T., Bi R., Hoe W., Schreiber S. S. and Baudry M. (2001b) Kainate excitotoxicity in organotypic hippocampal slice cultures: evidence for multiple apoptotic pathways. Brain Res. 916, 239-248.
    • (2001) Brain Res. , vol.916 , pp. 239-248
    • Liu, W.1    Liu, R.2    Chun, J.T.3    Bi, R.4    Hoe, W.5    Schreiber, S.S.6    Baudry, M.7
  • 29
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
    • Liu X., Kim C. N., Yang J., Jemmerson R. and Wang X. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 30
    • 0027976087 scopus 로고
    • Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: Evidence that astrocytes play an important role in antioxidative processes in the brain
    • Makar T. K., Nedergaard M., Preuss A., Gelbard A. S., Perumal A. S. and Cooper A. J. (1994) Vitamin E, ascorbate, glutathione, glutathione disulfide, and enzymes of glutathione metabolism in cultures of chick astrocytes and neurons: evidence that astrocytes play an important role in antioxidative processes in the brain. J. Neurochem. 62, 45-53.
    • (1994) J. Neurochem. , vol.62 , pp. 45-53
    • Makar, T.K.1    Nedergaard, M.2    Preuss, A.3    Gelbard, A.S.4    Perumal, A.S.5    Cooper, A.J.6
  • 31
    • 0028318638 scopus 로고
    • Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia- and acidosis-induced damage in hippocampal slices
    • Musleh W., Bruce A., Malfroy B. and Baudry M. (1994) Effects of EUK-8, a synthetic catalytic superoxide scavenger, on hypoxia- and acidosis-induced damage in hippocampal slices. Neuropharmacology 33, 929-934.
    • (1994) Neuropharmacology , vol.33 , pp. 929-934
    • Musleh, W.1    Bruce, A.2    Malfroy, B.3    Baudry, M.4
  • 32
    • 0002563935 scopus 로고    scopus 로고
    • Iron and neurodegeneration: Prospects for neuroprotection
    • Olanow C. W., Jenner P. and Youdim M., eds. Academic Press, London
    • Olanow C. W. and Youdim M. H. B. (1996) Iron and neurodegeneration: prospects for neuroprotection. In: Neurodegeneration and Neuroprotection in Parkinson's Disease (Olanow C. W., Jenner P. and Youdim M., eds), pp. 55-67. Academic Press, London.
    • (1996) Neurodegeneration and Neuroprotection in Parkinson's Disease , pp. 55-67
    • Olanow, C.W.1    Youdim, M.H.B.2
  • 33
    • 0034670065 scopus 로고    scopus 로고
    • Glial cells contribute more to iron and aluminum accumulation but are more resistant to oxidative stress than neuronal cells
    • Oshiro S., Kawahara M., Kuroda Y., Zhang C., Cai Y., Kitajima S. and Shirao M. (2000) Glial cells contribute more to iron and aluminum accumulation but are more resistant to oxidative stress than neuronal cells. Biochim. Biophys. Acta 1502, 405-414.
    • (2000) Biochim. Biophys. Acta , vol.1502 , pp. 405-414
    • Oshiro, S.1    Kawahara, M.2    Kuroda, Y.3    Zhang, C.4    Cai, Y.5    Kitajima, S.6    Shirao, M.7
  • 34
    • 0030924506 scopus 로고    scopus 로고
    • β-amyloid neurotoxicity in vitro: Evidence of oxidative stress but not protection by antioxidants
    • Pike C. J., Ramezan-Arab N. and Cotman C. W. (1997) β-Amyloid neurotoxicity in vitro: evidence of oxidative stress but not protection by antioxidants. J. Neurochem. 69, 1601-1611.
    • (1997) J. Neurochem. , vol.69 , pp. 1601-1611
    • Pike, C.J.1    Ramezan-Arab, N.2    Cotman, C.W.3
  • 35
    • 0034722098 scopus 로고    scopus 로고
    • Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons
    • Pong K., Doctrow S. R. and Baudry M. (2000) Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res. 881, 182-189.
    • (2000) Brain Res. , vol.881 , pp. 182-189
    • Pong, K.1    Doctrow, S.R.2    Baudry, M.3
  • 36
    • 0032579829 scopus 로고    scopus 로고
    • An in vitro model for analysis of oxidative death in primary mouse astrocytes
    • Robb S. J. and Connor J. R. (1998) An in vitro model for analysis of oxidative death in primary mouse astrocytes. Brain Res. 788, 125-132.
    • (1998) Brain Res. , vol.788 , pp. 125-132
    • Robb, S.J.1    Connor, J.R.2
  • 37
    • 0033578309 scopus 로고    scopus 로고
    • EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
    • Rong Y., Doctrow S. R., Tocco G. and Baudry M. (1999) EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Natl Acad. Sci. USA 96, 9897-9902.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9897-9902
    • Rong, Y.1    Doctrow, S.R.2    Tocco, G.3    Baudry, M.4
  • 39
    • 0027209389 scopus 로고
    • Strategies of antioxidant defense
    • Sies H. (1993) Strategies of antioxidant defense. Eur. J. Biochem. 215, 213-219.
    • (1993) Eur. J. Biochem. , vol.215 , pp. 213-219
    • Sies, H.1
  • 40
    • 0021236076 scopus 로고
    • Cerebral circulation and metabolism
    • Siesjo B. K. (1984) Cerebral circulation and metabolism. J. Neurosurg 60, 883-908.
    • (1984) J. Neurosurg. , vol.60 , pp. 883-908
    • Siesjo, B.K.1
  • 41
    • 0030885482 scopus 로고    scopus 로고
    • Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
    • Smith M. A., Harris P. L., Sayre L. M. and Perry G. (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl Acad. Sci. USA 94, 9866-9868.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9866-9868
    • Smith, M.A.1    Harris, P.L.2    Sayre, L.M.3    Perry, G.4
  • 42
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L., Buchs P. A. and Muller D. (1991) A simple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173-182.
    • (1991) J. Neurosci. Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 43
    • 0033230119 scopus 로고    scopus 로고
    • Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species
    • Tanaka J., Toku K., Zhang B., Ishihara K., Sakanaka M. and Maeda N. (1999) Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species. Glia 28, 85-96.
    • (1999) Glia , vol.28 , pp. 85-96
    • Tanaka, J.1    Toku, K.2    Zhang, B.3    Ishihara, K.4    Sakanaka, M.5    Maeda, N.6
  • 46
    • 0024434025 scopus 로고
    • Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior
    • discussion 615-607
    • Youdim M. B., Ben-Shachar D. and Yehuda S. (1989) Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and behavior. Am. J. Clin. Nutr. 50, 607-615; discussion 615-607.
    • (1989) Am. J. Clin. Nutr. , vol.50 , pp. 607-615
    • Youdim, M.B.1    Ben-Shachar, D.2    Yehuda, S.3
  • 47
    • 0034641936 scopus 로고    scopus 로고
    • Apoptosis in the nervous system
    • Yuan J. and Yankner B. A. (2000) Apoptosis in the nervous system. Nature 407, 802-809.
    • (2000) Nature , vol.407 , pp. 802-809
    • Yuan, J.1    Yankner, B.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.