Metabolic engineering of plants for alkaloid production

Metabolic Engineering

Volumn 4, Issue 1, 2002, Pages 41-48

  Hughes, Erik H ^a   Shanks, Jacqueline V ^b  

^a Rice University   (United States)

^b Iowa State University of Science and Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0036332024     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1006/mben.2001.0205     Document Type: Article

References (64)

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2. Analysis of a cDNA encoding arginine decarboxylase from oat reveals similarity to the Escherichia coli arginine decarboxylase and evidence of protein processing
3. Increased production of serotonin by suspension and root cultures of Peganum harmala transformed with a tryptophan decarboxylase cDNA clone from Catharanthus roseus
4. Effects of over-expression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus
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6. Redirection of tryptophan leads to production of low indole glucosinolate canola
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14. Use of plant cells and organ culture in the production of biological chemicals
15. Alkaloid production by a Cinchona officinalis "Ledgeriana" hairy root culture containing constitutive expression constructs of tryptophan decarboxylase and strictosidine synthase cDNAs from Catharanthus roseus
16. Molecular cloning and analysis of strictosidine β-d-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus
17. Overexpression of a tryptophan decarboxylase cDNA in Catharanthus roseus crown gall calluses results in increased tryptamine levels but not in increased terpenoid indole alkaloid production
18. Over-expressing a yeast ornithine decarboxylase gene in transgenic roots of Nicotiana rustica can lead to enhanced nicotine accumulation
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24. Enhancement of scopolamine production in Hyoscyamus muticus L. hairy root cultures by genetic engineering
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33. Isolation and characterization of a cDNA clone from Catharanthus roseus encoding NADPH: Cytochrome P-450 monooxygenases in plants
34. Molecular cloning and functional identification of a plant ornithine decarboxylase cDNA
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37. Metabolic engineering for the production of plant secondary metabolites
38. Determination of metabolic rate-limitations by precursor feeding in Catharanthus roseus hairy root cultures
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40. Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor
41. Two tropinone reductases, that catalyse opposite stereospecific reductions in tropane alkaloid biosynthesis, are localized in plant root with different cell-specific patterns
42. Stable vindoline production in transformed cell cultures of Catharanthus roseus
43. Probing plant metabolism with NMR
44. Regulation of secondary metabolism in transformed root cultures
45. Biochemistry and physiology of alkaloids and betalains
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49. Recent natural products based drug development: A pharmaceutical industry perspective
50. The terminal O-acetyltransferase involved in vindoline biosynthesis defines a new class of proteins responsible for coenzyme A-dependent acyl transfer
51. Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate
52. Expression of Atropa belladonna putrescine N-methyltransferase gene in root pericycle
53. ORCA3, a jasmonate-responsive transcriptional regulator of plant primary and secondary metabolism
54. Molecular cloning and characterization of deacetoxyvindoline 4-hydroxylase, a 2-oxoglutarate dependent dioxygenase involved in the biosynthesis of vindoline in Catharanthus roseus (L.) G. Don
55. Cloning and expression of cDNAs encoding two enzymes of the MEP pathway in Catharanthus roseus
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58. Metabolic engineering of plant secondary metabolite pathways for the production of fine chemicals
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63. Metabolic engineering of medicinal plants: Transgenic Atropa belladonna with an improved alkaloid composition
64. Future trends of exploration for the biotechnological production of isoquinoline alkaloids