CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue

Diabetes

Volumn 56, Issue 7, 2007, Pages 1872-1880

  Hajri, Tahar ^a   Hall, Angela M ^b   Jensen, Dalan R ^c   Pietka, Terri A ^b   Drover, Victor A ^d   Tao, Huan ^a   Eckel, Robert ^c   Abumrad, Nada A ^b  

^a VANDERBILT UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; FATTY ACID; GLUCOSE; INSULIN; LEPTIN; STAT3 PROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY ACID TRANSPORT; FOOD INTAKE; GLUCOSE INTAKE; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; ANTIGENS, CD36; DISEASE MODELS, ANIMAL; FATTY ACIDS; LEPTIN; MICE; OBESITY; SIGNAL TRANSDUCTION;

EID: 34347385591     PISSN: 00121797     EISSN: 00121797     Source Type: Journal    
DOI: 10.2337/db06-1699     Document Type: Article

References (50)

1. Trayhurn P: Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 184:285-293, 2005
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
4. Bjorbaek C, Kahn BB: Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 59:305-331, 2004
5. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A 94:4637-4641, 1997
6. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387:903-908, 1997
7. Cohen P, Friedman JM: Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J Nutr 134:2455S-2463S, 2004
8. El-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J Clin Invest 105:1827-1832, 2000
9. Wang MY, Orci L, Ravazzola M, Unger RH: Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci U S A 102:18011-18016, 2005
10. Fried SK, Ricci MR, Russell CD, Laferrere B: Regulation of leptin production in humans. J Nutr 130:3127S-3131S, 2000
11. Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, Havel PJ: Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139:551-558, 1998
12. Cammisotto PG, Gelinas Y, Deshaies Y, Bukowiecki LJ: Regulation of leptin secretion from white adipocytes by free fatty acids. Am J Physiol Endocrinol Metab 285:E521-E526, 2003
13. Shintani M, Nishimura H, Yonemitsu S, Masuzaki H, Ogawa Y, Hosoda K, Inoue G, Yoshimasa Y, Nakao K: Downregulation of leptin by free fatty acids in rat adipocytes: effects of triacsin C, palmitate, and 2-bromopalmitate. Metabolism 49:326-330, 2000
14. Peino R, Fernandez Alvarez J, Penalva A, Considine RV, Rodriguez-Segade S, Rodriguez-Garcia J, Cordido F, Casanueva FF, Dieguez C: Acute changes in free-fatty acids (FFA) do not alter serum leptin levels. J Endocrinol Invest 21:526-530, 1998
15. Stumvoll M, Fritsche A, Tschritter O, Lehmann R, Wahl HG, Renn W, Haring H: Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids. Metabolism 49:335-339, 2000
16. Hajri T, Han XX, Bonen A, Abumrad NA: Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice. J Clin Invest 109:1381-1389, 2002
17. Coburn CT, Knapp FF Jr, Febbraio M, Beets AL, Silverstein RL, Abumrad NA: Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice. J Biol Chem 275:32523-32529, 2000
18. Febbraio M, Abumrad NA, Hajjar DP, Sharma K, Cheng W, Pearce SF, Silverstein RL: A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274:19055-19062, 1999
19. Jensen DR, Gayles EC, Ammon S, Phillips R, Eckel RH: A self-correcting indirect calorimeter system for the measurement of energy balance in small animals. J Appl Physiol 90:912-918, 2001
20. Drover VA, Abumrad NA: CD36-dependent fatty acid uptake regulates expression of peroxisome proliferator activated receptors. Biochem Soc Trans 33:311-315, 2005
21. Fried SK, Moustaid-Moussa N: Culture of adipose tissue and isolated adipocytes. In Adipose Tissue Protocols. Ailhaud G, Ed. Totowa, NJ, Humana Press, 2001, p. 197-212
22. Fisher FF, Trujillo ME, Hanif W, Barnett AH, McTernan PG, Scherer PE, Kumar S: Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48:1084-1087, 2005
23. Bastie CC, Hajri T, Drover VA, Grimaldi PA, Abumrad NA: CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsiveness. Diabetes 53:2209-2216, 2004
24. Thomas T, Gori F, Khosla S, Jensen MD, Burguera B, Riggs BL: Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes. Endocrinology 140:1630-1638, 1999
25. Goudriaan JR, Dahlmans VE, Teusink B, Ouwens DM, Febbraio M, Maassen JA, Romijn JA, Havekes LM, Voshol PJ: CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. J Lipid Res 44:2270-2277, 2003
26. Lee Y, Wang MY, Kakuma T, Wang ZW, Babcock E, McCorkle K, Higa M, Zhou YT, Unger RH: Liporegulation in diet-induced obesity: the antisteatotic role of hyperleptinemia. J Biol Chem 276:5629-5635, 2001
27. Febbraio M, Guy E, Coburn C, Knapp FF Jr, Beets AL, Abumrad NA, Silverstein RL: The impact of overexpression and deficiency of fatty acid translocase (FAT)/CD36. Mol Cell Biochem 239:193-197, 2002
28. De Vos P, Lefebvre AM, Miller SG, Guerre-Millo M, Wong K, Saladin R, Hamann LG, Staels B, Briggs MR, Auwerx J: Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma. J Clin Invest 98:1004-1009, 1996
29. Kallen CB, Lazar MA: Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 93:5793-5796, 1996
30. Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K, Ide T, Kubota N, Terauchi Y, Tobe K, Miki H, Tsuchida A, Akanuma Y, Nagai R, Kimura S, Kadowaki T: The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem 276:41245-41254, 2001
31. Kast-Woelbern HR, Dana SL, Cesario RM, Sun L, de Grandpre LY, Brooks ME, Osburn DL, Reifel-Miller A, Klausing K, Leibowitz MD: Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis. J Biol Chem 279:23908-23915, 2004
32. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM: mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234, 1994
33. Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 26:439-451, 2005
34. Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr: STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421:856-859, 2003
35. Buettner C, Pocai A, Muse ED, Etgen AM, Myers MG Jr, Rossetti L: Critical role of STAT3 in leptin's metabolic actions. Cell Metab 4:49-60, 2006
36. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB: Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409:729-733, 2001
37. Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, Sarraf P, Spiegelman BM, Lowell BB: Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter. J Biol Chem 272:5283-5290, 1997
38. Ho M, Foxall S, Higginbottom M, Donofrio DM, Liao J, Richardson PJ, Maneuf YP: Leptin-mediated inhibition of the insulin-stimulated increase in fatty acid uptake in differentiated 3T3-L1 adipocytes. Metabolism 55:8-12, 2006
39. Fan X, Bradbury MW, Berk PD: Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J Nutr 133:2707-2715, 2003
40. Palanivel R, Eguchi M, Shuralyova I, Coe I, Sweeney G: Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes. Metabolism 55:1067-1075, 2006
41. Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L: Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11:320 -327, 2005
42. Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889, 2004
43. Huan JN, Li J, Han Y, Chen K, Wu N, Zhao AZ: Adipocyte-selective reduction of the leptin receptors induced by antisense RNA leads to increased adiposity, dyslipidemia, and insulin resistance. J Biol Chem 278:45638-45650, 2003
44. Petrescu O, Fan X, Gentileschi P, Hossain S, Bradbury M, Gagner M, Berk PD: Long-chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. Int J Obes (Lond) 29:196-203, 2005
45. Aitman TJ, Cooper LD, Norsworthy PJ, Wahid FN, Gray JK, Curtis BR, McKeigue PM, Kwiatkowski D, Greenwood BM, Snow RW, Hill AV, Scott J: Malaria susceptibility and CD36 mutation. Nature 405:1015-1016, 2000
46. Yamashita S, Hirano KI, Kuwasako T, Janabi M, Toyama Y, Ishigami M, Sakai N: Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis: insights from CD36-deficient patients. Mol Cell Biochem 299:19-22, 2007
47. Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, Iori E, Lager RA, Shroff AR, Gervino EV, Nesto RW, Johnstone MT, Abumrad NA, Avogaro A, Trischitta V, Doria A: A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet 13:2197-2205, 2004
48. Corpeleijn E, van der Kallen CJ, Kruijshoop M, Magagnin MG, de Bruin TW, Feskens EJ, Saris WH, Blaak EE: Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with type 2 diabetes mellitus and insulin resistance. Diabet Med 23:907-911, 2006
49. Bonen A, Tandon NN, Glatz JF, Luiken JJ, Heigenhauser GJ: The fatty acid transporter FAT/CD36 is upregulated in subcutaneous and visceral adipose tissues in human obesity and type 2 diabetes. Int J Obes (Lond) 30:877-883, 2006
50. Lepretre F, Linton KJ, Lacquemant C, Vatin V, Samson C, Dina C, Chikri M, Ali S, Scherer P, Seron K, Vasseur F, Aitman T, Froguel P: Genetic study of the CD36 gene in a French diabetic population. Diabete Metab 30:459-463, 2004