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Volumn 43, Issue 9, 2006, Pages 541-548

Cannabinoid system and neuroinflammation: Therapeutic perspectives in multiple sclerosis;El sistema cannabinoide en situaciones de neuroinflamación: Perspectivas terapéuticas en la esclerosis múltiple

Author keywords

Cannabinoids; Glial cells; Immune function; Multiple sclerosis; Neuroinflammation

Indexed keywords

CANNABINOID RECEPTOR; CYTOKINE;

EID: 34347379750     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: 10.33588/rn.4309.2006259     Document Type: Review
Times cited : (6)

References (54)
  • 1
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y, Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964; 86: 1646-7.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 2
    • 23444432920 scopus 로고    scopus 로고
    • The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
    • Lambert MD, Fowler CJ. The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 2005; 48: 5059-87.
    • (2005) J Med Chem , vol.48 , pp. 5059-5087
    • Lambert, M.D.1    Fowler, C.J.2
  • 3
    • 0242584643 scopus 로고    scopus 로고
    • Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor
    • Offértaler L, Mo F, Bátkai S, Liu J, Begg M, Razdan RK, et al. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 2003; 63: 699-705.
    • (2003) Mol Pharmacol , vol.63 , pp. 699-705
    • Offértaler, L.1    Mo, F.2    Bátkai, S.3    Liu, J.4    Begg, M.5    Razdan, R.K.6
  • 4
    • 0033769188 scopus 로고    scopus 로고
    • Levels, metabolism and pharmacological activity of anandamide in CB1, cannabinoid receptor knock-out mice: Evidence for non CB1, nor CB2 receptor mediated actions of anandamide in mouse brain
    • Di Marzo V, Breivogel CS, Tao Q, Bridgen DT, Razdan RK, Zimmer AM, et al. Levels, metabolism and pharmacological activity of anandamide in CB1, cannabinoid receptor knock-out mice: evidence for non CB1, nor CB2 receptor mediated actions of anandamide in mouse brain. J Neurochem 2000; 75: 2434-44.
    • (2000) J Neurochem , vol.75 , pp. 2434-2444
    • Di Marzo, V.1    Breivogel, C.S.2    Tao, Q.3    Bridgen, D.T.4    Razdan, R.K.5    Zimmer, A.M.6
  • 6
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda LA, Lolait SJ, Browstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990; 346: 561-4.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Browstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 8
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signalling
    • Molina-Holgado E, Arévalo-Martín A, Vela JM, Almazán G, Molina-Holgado F, Borrell J, et al. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signalling J Neurosci 2002; 22: 9742-53.
    • (2002) J Neurosci , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Arévalo-Martín, A.2    Vela, J.M.3    Almazán, G.4    Molina-Holgado, F.5    Borrell, J.6
  • 9
    • 26444557412 scopus 로고    scopus 로고
    • The endocannabinoid system drives neural progenitors proliferation
    • Aguado T, Monory K, Palazuelos J, Stella N, Cravat B, Lutz B, et al. The endocannabinoid system drives neural progenitors proliferation. FASEB J 2005; 19: 1704-6.
    • (2005) FASEB J , vol.19 , pp. 1704-1706
    • Aguado, T.1    Monory, K.2    Palazuelos, J.3    Stella, N.4    Cravat, B.5    Lutz, B.6
  • 10
    • 32544441379 scopus 로고    scopus 로고
    • The endocannabinoid system promotes astroglial differentiation by acting on neural progenitors cells
    • Aguado T, Palazuelos J, Monory K, Stella N, Cravat B, Lutz B, et al. The endocannabinoid system promotes astroglial differentiation by acting on neural progenitors cells. J Neurosci 2006; 26: 1551-61.
    • (2006) J Neurosci , vol.26 , pp. 1551-1561
    • Aguado, T.1    Palazuelos, J.2    Monory, K.3    Stella, N.4    Cravat, B.5    Lutz, B.6
  • 11
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 1995; 232: 54-61.
    • (1995) Eur J Biochem , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3    Dussossoy, D.4    Carriere, D.5
  • 12
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty cid amide hydrolase are selectively overexpressed in neuritis plaques-associated glia in Alzheimer disease
    • Benito C, Núñez E, Tolón RM, Carrier EJ, Rábano A, Hillard CJ, et al. Cannabinoid CB2 receptors and fatty cid amide hydrolase are selectively overexpressed in neuritis plaques-associated glia in Alzheimer disease. J Neurosci 2003; 23: 11136-41.
    • (2003) J Neurosci , vol.23 , pp. 11136-11141
    • Benito, C.1    Núñez, E.2    Tolón, R.M.3    Carrier, E.J.4    Rábano, A.5    Hillard, C.J.6
  • 13
    • 9644268887 scopus 로고    scopus 로고
    • Cannabinoid signalling in glial cells
    • Stella N. Cannabinoid signalling in glial cells. Glia 2004; 48: 267-77.
    • (2004) Glia , vol.48 , pp. 267-277
    • Stella, N.1
  • 14
    • 26844504226 scopus 로고    scopus 로고
    • Identification and functional characterization of brain-stem cannabinoid CB2 receptors
    • Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie M, et al. Identification and functional characterization of brain-stem cannabinoid CB2 receptors. Science 2005; 310: 329-32.
    • (2005) Science , vol.310 , pp. 329-332
    • Van Sickle, M.D.1    Duncan, M.2    Kingsley, P.J.3    Mouihate, A.4    Urbani, P.5    Mackie, M.6
  • 15
    • 35348874221 scopus 로고
    • Pharmacology of cannabinoid receptors
    • Howlett AC. Pharmacology of cannabinoid receptors. Ann Rev Pharmacol Toxicol 1995; 273: 734-43.
    • (1995) Ann Rev Pharmacol Toxicol , vol.273 , pp. 734-743
    • Howlett, A.C.1
  • 16
    • 0035801320 scopus 로고    scopus 로고
    • Novel cannabinoid-sensitive receptors mediates inhibition of glutamatergic synaptic transmission in the hippocampus
    • Hájos N, Ledent C, Freund TF. Novel cannabinoid-sensitive receptors mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience 2001; 106: 1-4.
    • (2001) Neuroscience , vol.106 , pp. 1-4
    • Hájos, N.1    Ledent, C.2    Freund, T.F.3
  • 17
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992; 258: 1946-9.
    • (1992) Science , vol.258 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 18
    • 0028589390 scopus 로고
    • Formation and inactivation of endogenous cannabinoid anandamide in central neurons
    • Di Marzo V, Fontana A, Cadas H, Schinelli S, Cimino G, Schwartz JC, et al. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994; 372: 689-91.
    • (1994) Nature , vol.372 , pp. 689-691
    • Di Marzo, V.1    Fontana, A.2    Cadas, H.3    Schinelli, S.4    Cimino, G.5    Schwartz, J.C.6
  • 19
    • 0029012014 scopus 로고
    • Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
    • Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, et al. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem Pharmacol 1995; 50: 83-90.
    • (1995) Biochem Pharmacol , vol.50 , pp. 83-90
    • Mechoulam, R.1    Ben-Shabat, S.2    Hanus, L.3    Ligumsky, M.4    Kaminski, N.E.5    Schatz, A.R.6
  • 20
    • 33144473891 scopus 로고    scopus 로고
    • N arachidonoyl-L-serine, an endocannabinoid like brain constituent with vasodilatory properties
    • Milman G, Maor Y, Abu-Lafi, S, Horowitz, M, Gallily R, Batkai, S, et al. N arachidonoyl-L-serine, an endocannabinoid like brain constituent with vasodilatory properties. Proc Natl Aca Sci USA 2006; 103: 2428-33.
    • (2006) Proc Natl Aca Sci USA , vol.103 , pp. 2428-2433
    • Milman, G.1    Maor, Y.2    Abu-Lafi, S.3    Horowitz, M.4    Gallily, R.5    Batkai, S.6
  • 21
  • 22
    • 1842611887 scopus 로고    scopus 로고
    • The endocannabinoid system: A general view and latest additions
    • De Petrocellis L, Cascio MG, Di Marzo V. The endocannabinoid system: a general view and latest additions. Br J Pharmacol 2004; 141: 765-74.
    • (2004) Br J Pharmacol , vol.141 , pp. 765-774
    • De Petrocellis, L.1    Cascio, M.G.2    Di Marzo, V.3
  • 25
    • 0035499974 scopus 로고    scopus 로고
    • Modulation of transmitter release via presynaptic cannabinoid receptors
    • Shliker E, Kathmann M. Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 2001; 22: 565-72.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 565-572
    • Shliker, E.1    Kathmann, M.2
  • 26
    • 0035191240 scopus 로고    scopus 로고
    • Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation
    • Carlisle SJ, Marciano-Cabral F, Staab A, Ludwick C, Cabral GA. Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation. Int Immunopharmacol 2002; 2: 69-82.
    • (2002) Int Immunopharmacol , vol.2 , pp. 69-82
    • Carlisle, S.J.1    Marciano-Cabral, F.2    Staab, A.3    Ludwick, C.4    Cabral, G.A.5
  • 27
    • 0037442829 scopus 로고    scopus 로고
    • Non-psychotropic cannabinoid receptors regulate microglial cell migration
    • Walter L, Franklin A, Witting A, Wade C, Xie Y, Kunos K, et al. Non-psychotropic cannabinoid receptors regulate microglial cell migration. J. Neurosci 2003; 23: 1398-405.
    • (2003) J. Neurosci , vol.23 , pp. 1398-1405
    • Walter, L.1    Franklin, A.2    Witting, A.3    Wade, C.4    Xie, Y.5    Kunos, K.6
  • 28
    • 35348889586 scopus 로고    scopus 로고
    • Cultured rat microglial cells synthesize the endocannabinoid 2-arachydonyl glycerol, which increases proliferation via a CB2 receptor dependent mechanism
    • Carrier EJ, Kearn CS, Barkmaier AJ, Breese NM, Yang W, Nithipatikom K, et al. Cultured rat microglial cells synthesize the endocannabinoid 2-arachydonyl glycerol, which increases proliferation via a CB2 receptor dependent mechanism. Mol Pharmacol 2004; 60: 155-63.
    • (2004) Mol Pharmacol , vol.60 , pp. 155-163
    • Carrier, E.J.1    Kearn, C.S.2    Barkmaier, A.J.3    Breese, N.M.4    Yang, W.5    Nithipatikom, K.6
  • 29
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramírez BG, Blázquez C, Gómez del Pulgar T, Guzmán M, De Ceballos M. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J Neurosci 2005; 25: 1904-13.
    • (2005) J Neurosci , vol.25 , pp. 1904-1913
    • Ramírez, B.G.1    Blázquez, C.2    Gómez del Pulgar, T.3    Guzmán, M.4    De Ceballos, M.5
  • 30
    • 0032982520 scopus 로고    scopus 로고
    • The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
    • Waksman Y, Olson JM, Carlisle SJ, Cabral GA. The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J Pharmacol Exp Ther 1999; 288: 1357-66.
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1357-1366
    • Waksman, Y.1    Olson, J.M.2    Carlisle, S.J.3    Cabral, G.A.4
  • 31
    • 0037036436 scopus 로고    scopus 로고
    • Astrocytes in culture produce anandamide and other acylethanolamines
    • Walter L, Franklin A, Witting A, Möller T, Stella N. Astrocytes in culture produce anandamide and other acylethanolamines. J Biol Chem 2002; 277: 20869-76.
    • (2002) J Biol Chem , vol.277 , pp. 20869-20876
    • Walter, L.1    Franklin, A.2    Witting, A.3    Möller, T.4    Stella, N.5
  • 32
    • 0030795910 scopus 로고    scopus 로고
    • Anandamide suppresses nitric oxide and TNF-α responses to Theiler's virus or endotoxin in astrocytes
    • Molina-Holgado F, Lledó A. Guaza C. Anandamide suppresses nitric oxide and TNF-α responses to Theiler's virus or endotoxin in astrocytes. NeuroReport 1997; 8: 1929-33.
    • (1997) NeuroReport , vol.8 , pp. 1929-1933
    • Molina-Holgado, F.1    Lledó, A.2    Guaza, C.3
  • 33
    • 0031866598 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide potentiates IL-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway
    • Molina-Holgado F, Molina-Holgado E, Guaza C. The endogenous cannabinoid anandamide potentiates IL-6 production by astrocytes infected with Theiler's murine encephalomyelitis virus by a receptor-mediated pathway. FEBS Lett 1998; 433: 139-42.
    • (1998) FEBS Lett , vol.433 , pp. 139-142
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3
  • 34
    • 0037085572 scopus 로고    scopus 로고
    • Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide induced nitric oxide release in astrocyte cultures
    • Molina-Holgado F, Molina-Holgado E, Guaza C, Rothwell NJ. Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide induced nitric oxide release in astrocyte cultures. J Neurosci Res 2002; 67: 829-36.
    • (2002) J Neurosci Res , vol.67 , pp. 829-836
    • Molina-Holgado, F.1    Molina-Holgado, E.2    Guaza, C.3    Rothwell, N.J.4
  • 35
    • 27844552904 scopus 로고    scopus 로고
    • Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures
    • Ortega-Gutiérrez S, Molina-Holgado E, Guaza C. Effect of anandamide uptake inhibition in the production of nitric oxide and in the release of cytokines in astrocyte cultures. Glia 2005; 52: 166-8.
    • (2005) Glia , vol.52 , pp. 166-168
    • Ortega-Gutiérrez, S.1    Molina-Holgado, E.2    Guaza, C.3
  • 36
    • 0041842648 scopus 로고    scopus 로고
    • Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glial cells
    • Molina-Holgado F, Pinteaux E, Moore J, Molina-Holgado E, Guaza C, Gibson RM, et al. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glial cells. J Neurosci 2003; 23: 6470-4.
    • (2003) J Neurosci , vol.23 , pp. 6470-6474
    • Molina-Holgado, F.1    Pinteaux, E.2    Moore, J.3    Molina-Holgado, E.4    Guaza, C.5    Gibson, R.M.6
  • 37
    • 22044449933 scopus 로고    scopus 로고
    • Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 synthesis in murine macrophages: Role of IL-10 and ERK1/2 kinase signalling
    • Correa F, Mestre L, Docagne F, Guaza C. Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 synthesis in murine macrophages: role of IL-10 and ERK1/2 kinase signalling. Br J Pharmacol 2005; 145: 441-50.
    • (2005) Br J Pharmacol , vol.145 , pp. 441-450
    • Correa, F.1    Mestre, L.2    Docagne, F.3    Guaza, C.4
  • 38
    • 15244359387 scopus 로고    scopus 로고
    • Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis
    • Mestre L, Correa F, Arévalo-Martín A, Molina-Holgado E, Valenti M, Ortar G, et al. Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis J Neurochem 2005; 92: 1327-39.
    • (2005) J Neurochem , vol.92 , pp. 1327-1339
    • Mestre, L.1    Correa, F.2    Arévalo-Martín, A.3    Molina-Holgado, E.4    Valenti, M.5    Ortar, G.6
  • 39
    • 0242654882 scopus 로고    scopus 로고
    • UK MS Research Group. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): Multicentre randomised placeb-control trial
    • Zajicek J, Fox P, Sanders H, Wright D, Vickery J, Nunn A, et al, UK MS Research Group. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placeb-control trial. Lancet 2003; 362: 1517-26.
    • (2003) Lancet , vol.362 , pp. 1517-1526
    • Zajicek, J.1    Fox, P.2    Sanders, H.3    Wright, D.4    Vickery, J.5    Nunn, A.6
  • 44
    • 0037397037 scopus 로고    scopus 로고
    • Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R (+) WIN55,212
    • Croxford JL, Miller SD. Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R (+) WIN55,212. J Clin Invest 2003; 111: 1231-40.
    • (2003) J Clin Invest , vol.111 , pp. 1231-1240
    • Croxford, J.L.1    Miller, S.D.2
  • 46
    • 26944483132 scopus 로고    scopus 로고
    • Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis
    • Cabranes A, Venderova K, De Lago E, Fezza F, Sánchez A, Mestre L, et al. Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis Neurobiol Dis 2005; 20: 207-17.
    • (2005) Neurobiol Dis , vol.20 , pp. 207-217
    • Cabranes, A.1    Venderova, K.2    De Lago, E.3    Fezza, F.4    Sánchez, A.5    Mestre, L.6
  • 47
    • 0035452419 scopus 로고    scopus 로고
    • Changes in cannabinoid CB1 receptors in striatal and cortical regions of rat with experimental allergic encephalomyelitis, an animal model of multiple sclerosis
    • Berrendero F, Sánchez A, Cabranes A, Puerta C, Ramos JA, García-Merino A, et al. Changes in cannabinoid CB1 receptors in striatal and cortical regions of rat with experimental allergic encephalomyelitis, an animal model of multiple sclerosis. Synapse 2001; 41: 195-202.
    • (2001) Synapse , vol.41 , pp. 195-202
    • Berrendero, F.1    Sánchez, A.2    Cabranes, A.3    Puerta, C.4    Ramos, J.A.5    García-Merino, A.6
  • 48
    • 29544446576 scopus 로고    scopus 로고
    • The endogenous anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells
    • Eljaschewitsch E, Witting A, Mawrin C, Lee T, Schmidt PM, Wolf S, et al. The endogenous anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 2006; 49: 67-79.
    • (2006) Neuron , vol.49 , pp. 67-79
    • Eljaschewitsch, E.1    Witting, A.2    Mawrin, C.3    Lee, T.4    Schmidt, P.M.5    Wolf, S.6
  • 51
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in focal and global cerebral ischemia and neuronal cultures
    • Nagayama T, Sinor AD, Simon RP, Chen J, Graham SH, Jin K, et al. Cannabinoids and neuroprotection in focal and global cerebral ischemia and neuronal cultures. J Neurosci 1999; 19: 2987-95.
    • (1999) J Neurosci , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6
  • 52
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait AM, Gallily R, Sumariwalla PF, Malik AS, Andreakos E, Mechoulam R, et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000; 97: 9561-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6
  • 53
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid based drugs as anti-inflammatory therapeutics
    • Klein TW. Cannabinoid based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005; 5: 400-11.
    • (2005) Nat Rev Immunol , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 54
    • 16544377251 scopus 로고    scopus 로고
    • Win 55212,2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in a experimental autoimmune encephalomyelitis model
    • Ni X, Geller EB, Eppihimer MJ, Eisenstein TK, Adler MW, Tuma RF. Win 55212,2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in a experimental autoimmune encephalomyelitis model. Mult Scler 2004; 10: 258-64.
    • (2004) Mult Scler , vol.10 , pp. 258-264
    • Ni, X.1    Geller, E.B.2    Eppihimer, M.J.3    Eisenstein, T.K.4    Adler, M.W.5    Tuma, R.F.6


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