Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes

Molecular and Cellular Biology

Volumn 27, Issue 13, 2007, Pages 4708-4719

  Pick, Elah ^a   Lau, On Sun ^a   Tsuge, Tomohiko ^b,c   Menon, Suchithra ^a   Tong, Yingchun ^a   Dohmae, Naoshi ^c   Plafker, Scott M ^d   Xing, Wang Deng ^a   Wei, Ning ^a  

^a YALE UNIVERSITY   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c RIKEN   (Japan)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN CUL4A; PROTEIN DET1; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARABIDOPSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MAMMAL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; CARRIER PROTEINS; CELL CYCLE PROTEINS; CULLIN PROTEINS; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; SUBSTRATE SPECIFICITY; THERMODYNAMICS; UBIQUITIN; UBIQUITIN-CONJUGATING ENZYMES; ULTRAVIOLET RAYS;

ARABIDOPSIS; ARABIDOPSIS THALIANA; MAMMALIA;

EID: 34347349073     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02432-06     Document Type: Article

References (43)

1. Angers, S., T. Li, X. Yi, M. J. Maccoss, R. T. Moon, and N. Zheng. 2006. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Nature 443:590-593.
2. Benvenuto, G., F. Formiggini, P. Laflamme, M. Malakhov, and C. Bowler. 2002. The photomorphogenesis regulator DET1 binds the amino-terminal tail of histone H2B in a nucleosome context. Curr. Biol. 12:1529-1534.
3. Bernhardt, A., E. Lechner, P. Hano, V. Schade, M. Dieterle, M. Anders, M. J. Dubin, G. Benvenuto, C. Bowler, P. Genschik, and H. Hellmann. 2006. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 47:591-603.
4. Bondar, T., E. V. Mirkin, D. S. Ucker, W. E. Walden, S. M. Mirkin, and P. Raychaudhuri. 2003. Schizosaccharomyces pombe Ddb1 is functionally linked to the replication checkpoint pathway. J. Biol. Chem. 278:37006-37014.
5. Chen, H., Y. Shen, X. Tang, L. Yu, J. Wang, L. Guo, Y. Zhang, H. Zhang, S. Feng, E. Strickland, N. Zheng, and X. W. Deng. 2006. Arabidopsis CULLIN4 forms an E3 ubiquitin ligase with RBX1 and the CDD complex in mediating light control of development. Plant Cell 18:1991-2004.
6. Chory, J., C. Peto, R. Feinbaum, L. Pratt, and F. Ausubel. 1989. Arabidopsis thaliana mutant that develops as a light-grown plant in the absence of light. Cell 58:991-999.
7. + channel. Mol. Cell. Biol. 24:2397-2409.
8. Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351-361.
9. Gao, M., T. Labuda, Y. Xia, E. Gallagher, D. Fang, Y. C. Liu, and M. Karin. 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science 306:271-275.
10. Groisman, R., J. Polanowska, I. Kuraoka, J. Sawada, M. Saijo, R. Drapkin, A. F. Kisselev, K. Tanaka, and Y. Nakatani. 2003. The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage. Cell 113:357-367.
11. He, Y. J., C. M. McCall, J. Hu, Y. Zeng, and Y. Xiong. 2006. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases. Genes Dev. 20:2949-2954.
12. Hershko, A., and A. Ciechanover. 1998. The ubiquitin system. Annu. Rev. Biochem. 67:425-479.
13. Higa, L. A., I. S. Mihaylov, D. P. Banks, J. Zheng, and H. Zhang. 2003. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat. Cell Biol. 5:1008-1015.
14. Hochstrasser, M. 2006. Lingering mysteries of ubiquitin-chain assembly. Cell 124:27-44.
15. Hofmann, R. M., and C. M. Pickart. 1999. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96:645-653.
16. Ito, K., S. Adachi, R. Iwakami, H. Yasuda, Y. Muto, N. Seki, and Y. Okano. 2001. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Eur. J. Biochem. 268:2725-2732.
17. Jin, J., E. E. Arias, J. Chen, J. W. Harper, and J. C. Walter. 2006. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol. Cell 23:709-721.
18. Kamura, T., K. Maenaka, S. Kotoshiba, M. Matsumoto, D. Kohda, R. C. Conaway, J. W. Conaway, and K. I. Nakayama. 2004. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Genes Dev. 18:3055-3065.
19. Kapetanaki, M. G., J. Guerrero-Santoro, D. C. Bisi, C. L. Hsieh, V. Rapic-Otrin, and A. S. Levine. 2006. The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc. Natl. Acad. Sci. USA 8:2588-2593.
20. Kraft, E. L., S. Stone, L. Ma, N. Su, Y. Gao, O. Lau, X. W. Deng, and J. Callis. 2005. Genome analysis and functional characterization of the E2 and RING-type E3 ligase ubiquitination enzymes of Arabidopsis. Plant Physiol. 139:1597-1611.
21. Li, T., X. Chen, K. C. Garbutt, P. Zhou, and N. Zheng. 2006. Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase. Cell 124:105-117.
22. Lieberman, M., O. Segev, N. Gilboa, A. Lalazar, and I. Levin. 2004. The tomato homolog of the gene encoding UV-damaged DNA binding protein 1 (DDB1) underlined as the gene that causes the high pigment-1 mutant phenotype. Theor. Appl. Genet. 108:1574-1581.
23. + stimulates a Pcu4-Ddb1-CSN ubiquitin ligase. EMBO J. 24: 3940-3951.
24. Ma, L., H. Zhao, and X. W. Deng. 2003. Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development. Development 5:969-981.
25. Matuschewski, K., H. P. Hauser, M. Treier, and S. Jentsch. 1996. Identification of a novel family of ubiquitin-conjugating enzymes with distinct aminoterminal extensions. J. Biol. Chem. 271:2789-2794.
26. Mustilli, A. C., F. Fenzi, R. Ciliento, F. Alfano, and C. Bowler. 1999. Phenotype of the tomato high pigment-2 mutant is caused by a mutation in the tomato homolog of DEETIOLATED1. Plant Cell 11:145-157.
27. Nateri, A. S., L. Riera-Sans, C. Da Costa, and A. Behrens. 2004. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303: 1374-1378.
28. Pepper, A., T. Delaney, T. Washburn, D. Poole, and J. Chory. 1994. DET1, a negative regulator of light-mediated development and gene expression in Arabidopsis, encodes a novel nuclear-localized protein. Cell 78:109-116.
29. Plafker, S. M., and I. G. Macara. 2000. Importin-11, a nuclear import receptor for the ubiquitin-conjugating enzyme, UbcM2. EMBO J. 19:5502-5513.
30. Plafker, S. M., K. S. Plafker, A. M. Weissman, and I. G. Macara. 2004. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. J. Cell Biol. 167:649-659.
31. Rapic-Otrin, V., V. Navazza, T. Nardo, E. Botta, M. McLenigan, D. C. Bisi, A. S. Levine, and M. Stefanini. 2003. True XP group E patients have a defective UV-damaged DNA binding protein complex and mutations in DDB2 which reveal the functional domains of its p48 product. Hum. Mol. Genet. 12:1507-1522.
32. Sabile, A., A. M. Meyer, C. Wirbelauer, D. Hess, U. Kogel, M. Scheffner, and W. Krek. 2006. Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein. Mol. Cell. Biol. 26:5994-6004.
33. Schroeder, D. F., M. Gahrtz, B. B. Maxwell, R. K. Cook, J. M. Kan, J. M. Alonso, J. R. Echer, and J. Chory. 2002. De-etiolated 1 and damaged DNA binding protein 1 interact to regulate Arabidopsis photomorphogenesis. Curr. Biol. 12:1462-1472.
34. Song, H. R., and I. A. Carre. 2005. DET1 regulates the proteasomal degradation of LHY, a component of the Arabidopsis circadian clock. Plant Mol. Biol. 57:761-771.
35. Sugasawa, K., Y. Okuda, M. Saijo, R. Nishi, N. Matsuda, G. Chu, T. Mori, S. Iwai, K. Tanaka, K. Tanaka, and F. Hanaoka. 2005. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell 121:387-400.
36. Suzuki, G., Y. Yanagawa, S. F. Kwok, M. Matsui, and X. W. Deng. 2002. Arabidopsis COP10 is a ubiquitin-conjugating enzyme variant that acts together with COP1 and the COP9 signalosome in repressing photomorphogenesis. Genes Dev. 16:554-559.
37. Wang, H., L. Zhai, J. Xu, H. Y. Joo, S. Jackson, H. Erdjument-Bromage, P. Tempst Y. Xiong, and Y. Zhang. 2006. Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol. Cell 3:383-394.
38. Wei, N., and X. W. Deng. 2003. The COP9 signalosome. Annu. Rev. Cell Dev. Biol. 19:261-286.
39. Wertz, I. E., K M. O'Rourke, Z. Zhang, D. Dornan, D. Arnott, R. J. Deshaies, and V. M. Dixit. 2004. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science 303:1371-1374.
40. Wu, K., K. Yamoah, G. Dolios, T. Gan-Erdene, P. Tan, A. Chen, C. G. Lee, N. Wei, K. D. Wilkinson, R. Wang, and Z. Q. Pan. 2003. DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1 J. Biol. Chem. 278:28882-28891.
41. Yanagawa, Y., J. A. Sullivan, S. Komatsu, G. Gusmaroli, G. Suzuki, J. Yin, T. Ishibashi, Y. Sayo, V. Rubio, S. Kimura, J. Wang, and X. W. Deng. 2004. Arabidopsis COP10 forms a complex with DDB1 and DET1 in vivo and enhances the activity of ubiquitin conjugating enzymes. Genes Dev. 18:2172-2181.
42. Yi, C., and X. W. Deng. 2005. COP1-from plant photomorphogenesis to mammalian tumorigenesis. Trends Cell Biol. 15:618-625.
43. Zhu, B., Y. Zheng, A. D. Pham, S. S. Mandal, H. Erdjument-Bromage, P. Tempst, and D. Reinberg. 2005. Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20:601-611.