The role of epithelial-mesenchymal transition in oral squamous cell carcinoma and oral submucous fibrosis

Clinica Chimica Acta

Volumn 383, Issue 1-2, 2007, Pages 51-56

  Yanjia, Hu ^a   Xinchun, Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

(TGF ); Epithelial mesenchymal transition (EMT); Oral submucous fibrosis (OSF); Pathway; Transforming growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKERATIN 18; CYTOSKELETON PROTEIN; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR; FIBRONECTIN; GELATINASE A; GELATINASE B; HIGH MOBILITY GROUP A2 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOGENIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SCATTER FACTOR; SMAD2 PROTEIN; SMAD3 PROTEIN; SOMATOMEDIN; TENASCIN; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; UVOMORULIN; VIMENTIN;

CANCER SURVIVAL; EPITHELIUM CELL; FIBROGENESIS; HISTOPATHOLOGY; HUMAN; KERATINOCYTE; MESENCHYME CELL; MORPHOGENESIS; MOUTH CARCINOMA; MOUTH DISEASE; MOUTH INJURY; MOUTH MUCOSA; NONHUMAN; PATHOGENESIS; PRECANCER; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; SYSTEMATIC REVIEW; WOUND HEALING;

CARCINOMA, SQUAMOUS CELL; EPITHELIUM; HUMANS; MESODERM; MOUTH NEOPLASMS; ORAL SUBMUCOUS FIBROSIS;

PIPER BETEL;

EID: 34347336432     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2007.04.014     Document Type: Review

References (75)

1. Ranganathan K., Kavitha R., Sawant S., et al. Cytokeratin expression in oral submucous fibrosis-an immunohistochemical study. J Oral Pathol Med 35 (2006) 25-32
2. Tilakaratne W.M., Klinikowski M.F., Saku T., et al. Oral submucous fibrosis: review on aetiology and pathogenesis. Oral Oncol 42 (2006) 561-568
3. Chiang C.P., Hsieh R.P., Chen T.H., et al. High incidence of autoantibodies in Taiwanese patients with oral submucous fibrosis. J Oral Pathol Med 31 (2002) 402-409
4. Shook D., and Keller R. Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development. Mech Dev 120 (2003) 1351-1383
5. Iwano M., Plieth D., Danoff T.M., et al. Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest 110 (2002) 341-350
6. Desmouliere A. Factors influencing myofibroblast differentiation during wound healing and fibrosis. Cell Biol Int 19 (1995) 471-476
7. Ackland M.L., Newgreen D.F., Fridman M., et al. Epidermal growth factor-induced epithelio-mesenchymal transition in human breast carcinoma cells. Lab Invest 83 (2003) 435-448
8. Yang J., Mani S.A., Donaher J.L., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117 (2004) 927-939
9. Grunert S., Jechlinger M., and Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nat Rev Mol Cell Biol 4 (2003) 657-665
10. Okada H., Danoff T.M., Kalluri R., et al. Early role of Fsp1 in epithelial-mesenchymal transformation. Am J Physiol 273 (1997) 563-574
11. Greenburg G., and Hay E.D. Epithelia suspended in collagen gels can lose polarity and express characteristics of migrating mesenchymal cells. J Cell Biol 95 (1982) 333-339
12. Hay E.D. An overview of epithelio-mesenchymal transformation. Acta Anat (Basel) 154 (1995) 8-20
13. Saika S., Kono-Saika S., Ohnishi Y., et al. Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury. Am J Pathol 164 (2004) 651-663
14. Wu Z., Yang L., Cai L., et al. Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse. Respir Res 8 (2007) 1
15. Tahashi Y., Matsuzaki K., Date M., et al. Differential regulation of TGF-beta signal in hepatic stellate cells between acute and chronic rat liver injury. Hepatology 35 (2002) 49-61
16. Neilson E.G. Setting a trap for tissue fibrosis. Nat Med 11 (2005) 373-374
17. Kalluri R., and Neilson E.G. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112 (2003) 1776-1784
18. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2 (2002) 442-454
19. Peinado H., Portillo F., and Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int J Dev Biol 48 (2004) 365-375
20. Barrallo-Gimeno A., and Nieto M.A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132 (2005) 3151-3161
21. Moody S.E., Perez D., Pan T.C., et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8 (2005) 197-199
22. Petersen O.W., Nielsen H.L., Gudjonsson T., et al. Epithelial to mesenchymal transition in human breast cancer can provide a nonmalignant stroma. Am J Pathol 162 (2003) 391-392
23. Huber M.A., Azoitei N., Baumann B., et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 114 (2004) 569-581
24. Yang Y., Zhao S., and Song J. Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor beta1. Int J Biochem Cell Biol 36 (2004) 223-234
25. Ten D.P., Goumans M.J., Itoh F., et al. Regulation of cell proliferation by Smad proteins. J Cell Physiol 191 (2002) 1-16
26. Massague J., and Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 19 (2000) 1745-1754
27. Saika S., Ikeda K., Yamanaka O., et al. Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest 84 (2004) 1259-1270
28. Kloth J.N., Fleuren G.J., Oosting J., et al. Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines. Carcinogenesis 26 (2005) 1493-2
29. Zeisberg M., Hanai J., Sugimoto H., et al. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9 (2003) 964-968
30. Zeisberg M., Bottiglio C., Kumar N., et al. Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Renal Physiol 285 (2003) 1060-1067
31. Yoshikawa M., Hishikawa K., Marumo T., et al. Inhibition of histone deacetylase activity suppresses epithelial-to-mesenchymal transition induced by TGF-beta1 in human renal epithelial cells. J Am Soc Nephrol 18 (2007) 58-65
32. Rees J.R., Onwuegbusi B.A., Save V.E., et al. In vivo and in vitro evidence for transforming growth factor-{beta}1-mediated epithelial to mesenchymal transition in esophageal adenocarcinoma. Cancer Res 66 (2006) 9583-9590
33. Tan X., Li Y., and Liu Y. Therapeutic role and potential mechanisms of active vitamin D in renal interstitial fibrosis. J Steroid Biochem Mol Biol 103 (2007) 491-496
34. Xavier S., Piek E., Fujii M., et al. Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 279 (2004) 15167-15176
35. Portella G., Cumming S.A., Liddell J., et al. Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ 9 (1998) 393-394
36. Birchmeier C., Birchmeier W., and Brand-Saberi B. Epithelial-mesenchymal transitions in cancer progression. Acta Anat (Basel) 156 (1996) 217-226
37. Ellenrieder V., Hendler S.F., Boeck W., et al. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 61 (2001) 4222-4228
38. Miyazawa J., Mitoro A., Kawashiri S., et al. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res 64 (2004) 2024-2029
39. Reeves R., Edberg D.D., and Li Y. Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells. Mol Cell Biol 21 (2001) 575-594
40. Mattijssen V., Peters H.M., Schalkwijk L., et al. E-cadherin expression in head and neck squamous-cell carcinoma is associated with clinical outcome. Int J Cancer 55 (1993) 580-585
41. Yokoyama K., Kamata N., Hayashi E., et al. Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro. Oral Oncol 37 (2001) 65-71
42. Maeda G., Chiba T., Okazaki M., et al. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int J Oncol 27 (2005) 1535-1541
43. Comijn J., Berx G., Vermassen P., et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 7 (2001) 1267-1278
44. Guaita S., Puig I., Franci C., et al. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem 277 (2002) 39209-39216
45. Peinado H., Quintanilla M., and Cano A. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278 (2003) 21113-21123
46. Taki M., Verschueren K., Yokoyama K., et al. Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Int J Oncol 28 (2006) 487-496
47. Yokoyama K., Kamata N., Fujimoto R., et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int J Oncol 22 (2003) 891-898
48. Taki M., Kamata N., Yokoyama K., et al. Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Cancer Sci 94 (2003) 593-597
49. Onoue T., Uchida D., Begum N.M., et al. Epithelial-mesenchymal transition induced by the stromal cell-derived factor-1/CXCR4 system in oral squamous cell carcinoma cells. Int J Oncol 29 (2006) 1133-1138
50. Grille S.J., Bellacosa A., Upson J., et al. The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res 63 (2003) 2172-2178
51. Chung C.H., Parker J.S., Ely K., et al. Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-{kappa}B signaling as characteristics of a high-risk head and neck squamous cell carcinoma. Cancer Res 66 (2006) 8210-8218
52. Barker J.N., Mitra R.S., Griffiths C.E., et al. Keratinocytes as initiators of inflammation. Lancet 337 (1991) 211-214
53. Jeng J.H., Hahn L.J., Lin B.R., et al. Effects of areca nut, inflorescence piper betel extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. J Oral Pathol Med 28 (1999) 64-71
54. Jeng J.H., Wang Y.J., Chiang B.L., et al. Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. Carcinogenesis 24 (2003) 1301-1315
55. Gao Y., Ling T., and Wu H. Expression of transforming growth factor beta 1 in keratinocytes of oral submucous fibrosis tissue. Zhonghua Kou Qiang Yi Xue Za Zhi 32 (1997) 239-241
56. Xu C., Peng X., and Liu S. Localization of endothelin-1 in biopsies from oral submucous fibrosis: immunoelectron microscopic study. Zhonghua Kou Qiang Yi Xue Za Zhi 35 (2000) 215-217
57. Feng Y., and Ling T. Changes of cytokines secreted by human oral mucosa keratinocytes from oral submucous fibrosis in vitro. Hua Xi Kou Qiang Yi Xue Za Zhi 18 (2000) 23-25
58. Rajalalitha P., and Vali S. Molecular pathogenesis of oral submucous fibrosis-a collagen metabolic disorder. J Oral Pathol Med 34 (2005) 321-328
59. Chang M.C., Ho Y.S., Lee P.H., et al. Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. Carcinogenesis 22 (2001) 1527-1535
60. Sundqvist K., and Grafstrom R.C. Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. Int J Cancer 52 (1992) 305-310
61. Chang Y.C., Tsai C.H., Tai K.W., et al. Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis. Oral Oncol 38 (2002) 425-430
62. Ranganathan K., Kavitha R., Sawant S.S., et al. Cytokeratin expression in oral submucous fibrosis-an immunohistochemical study. J Oral Pathol Med 35 (2006) 25-32
63. Utsunomiya H., Tilakaratne W.M., Oshiro K., et al. Extracellular matrix remodeling in oral submucous fibrosis: its stage-specific modes revealed by immunohistochemistry and in situ hybridization. J Oral Pathol Med 34 (2005) 498-7
64. Liu S.Y., Lin M.H., Yang S.C., et al. Increased expression of matrix metalloproteinase-2 in oral cells after short-term stimulation and long-term usage of areca quid. J Formos Med Assoc 104 (2005) 390-397
65. Liu S.Y., Lin M.H., Yang S.C., et al. Areca quid chewing enhances the expression of salivary matrix metalloproteinase-9. J Formos Med Assoc 104 (2005) 113-119
66. Yang S.F., Hsieh Y.S., Tsai C.H., et al. Increased plasminogen activator inhibitor-1/tissue type plasminogen activator ratio in oral submucous fibrosis. Oral Dis 13 (2007) 234-238
67. Haque M.F., Harris M., Meghji S., et al. Immunolocalization of cytokines and growth factors in oral submucous fibrosis. Cytokine 10 (1998) 713-719
68. Tsai C.H., Yang S.F., Chen Y.J., et al. The upregulation of insulin-like growth factor-1 in oral submucous fibrosis. Oral Oncol 41 (2005) 940-946
69. Ni W.F., Tsai C.H., Yang S.F., et al. Elevated expression of NF-kappaB in oral submucous fibrosis - evidence for NF-kappaB induction by safrole in human buccal mucosal fibroblasts. Oral Oncol (2006) 1430195913-0
70. Chen J., and Liu Z. Study on the expression of Smad2/3 protein in oral submucous fibrosis. J Clin Stomatol 22 (2006) 43-45
71. Lin S.C., Lu S.Y., Lee S.Y., et al. Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes. Int J Cancer 116 (2005) 526-535
72. Yang Y., Pan X., Lei W., et al. Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene (2006) 7235-7244
73. Lu S.Y., Chang K.W., Liu C.J., et al. Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte. Carcinogenesis 27 (2006) 1273-1284
74. Yang S.C., Lin S.C., Chiang W.F., et al. Areca nut extract treatment elicits the fibroblastoid morphological changes, actin re-organization and signaling activation in oral keratinocytes. J Oral Pathol Med 32 (2003) 600-605
75. Liu Y. Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15 (2004) 1-12