Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice

Journal of Neuroscience

Volumn 17, Issue 23, 1997, Pages 9113-9121

  Liebl, Daniel J ^a   Tessarollo, Lino ^b   Palko, Mary Ellen ^b   Parada, Luis F ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

BDNF; Gene targeting; Neurotrophins; NT 3; Sensory neurons; Trk

Indexed keywords

NEUROTROPHIC FACTOR; NEUROTROPHIN 3;

ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL SURVIVAL; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE MUTATION; GENE TARGETING; GENETIC HETEROGENEITY; MOUSE; NERVE FUNCTION; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SENSORY NERVE CELL;

EID: 0030670840     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-23-09113.1997     Document Type: Article

References (25)

1. Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M (1996) Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron 16:287-295.
2. Angeletti PU, Levi-Montalcini R (1972) Growth inhibition of sympathetic cells by some adrenergic blocking agents (6-hydroxydopaminemice and rats-immunosympathectomy-chemical sympathectomy-superior cervical ganglion). Proc Natl Acad Sci USA 69:86-88.
3. Barbacid M (1994) The Trk family of neurotrophin receptors [review]. J Neurobiol 25:1386-1403.
4. Barde YA (1994) Neurotrophins: a family of proteins supporting the survival of neurons [review]. Prog Clin Biol Res 390:45-56.
5. Barker PA, Lomen-Hoerth C, Gensch EM, Meakin SO, Glass DJ, Shooter EM (1993) Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J Biol Chem 268:15150-15157.
6. Clary DO, Reichardt LF (1994) An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc Natl Acad Sci USA 91:11133-11137.
7. Conover JC, Erickson JT, Katz DM, Bianchi LM, Poueymirou WT, McClain J, Pan L, Helgren M, Ip NY, Boland P, Friedman B, Wiegand S, Veisada R, Kato AC, DeChiara TM, Yancopoulos GO (1995) Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4. Nature 375:235-238.
8. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, Ling LH, MacMahon SB, Shelton DL, Levinson AD, Phillips HS (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011.
9. Davies AM (1994) Neurotrophic factors. Switching neurotrophin dependence [review]. Curr Biol 4:273-276.
10. Davies AM, Lumsden A (1990) Ontogeny of the somatosensory system: origins and early development of primary sensory neurons [review]. Annu Rev Neurosci 13:61-73.
11. ElShamy WM, Linnarsson S, Lee KF, Jaenisch R, Ernfors P (1996) Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets. Development 122:491-500.
12. Ernfors P (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron 14:1153-1164.
13. Ernfors P, Lee KF, Jaenisch R (1994a) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368:147-150.
14. Ernfors P, Lee KF, Kucera J, Jaenisch R (1994b) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503-512.
15. Fariñas I, Jones KR, Backus C, Wang XY, Reichardt LF (1994) Severe sensory and sympathetic deficits in mice lacking neurotrophin-3. Nature 369:658-661.
16. Farinas I, Yoshida CK, Backus C, Reichardt LF (1996) Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors. Neuron 17:1065-1078.
17. Hamburger V, Yip JW (1984) Reduction of experimentally induced neuronal death in spinal ganglia of the chick embryo by nerve growth factor. J Neurosci 4:767-774.
18. Johnson Jr EM, Gorin PD, Brandeis LD, Pearson J (1980) Dorsal root ganglion neurons are destroyed by exposure in utero to maternal antibody to nerve growth factor. Science 210:916-918.
19. Jones KR, Fariñas I, Backus C, Reichardt LF (1994) Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76:989-999.
20. Kaplan DR, Hempstead BL, Martin-Zanca D, Chao MV, Parada LF (1991) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor [see comments]. Science 252:554-558.
21. Klein R, Conway D, Parada LF, Barbacid M (1990) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 61:647-656.
22. Klein R, Silas-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M (1994) Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements [see comments]. Nature 368:249-251.
23. Lamballe F, Smeyne RJ, Barbacid M (1994) Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J Neurosci 14:14-28.
24. Vogel KS, Brannan CI, Jenkins NA, Copeland NG, Parada LF (1995) Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell 82:733-742.
25. White FA, Silos-Santiago I, Molliver DC, Nishimura M, Phillips H, Barbacid M, Snider WD (1996) Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. J Neurosci 16:4662-4672.