A model for triple helix formation on human telomerase reverse transcriptase (hTERT) promoter and stabilization by specific interactions with the water soluble perylene derivative, DAPER

Biophysical Chemistry

Volumn 129, Issue 1, 2007, Pages 70-81

  Rossetti, Luigi ^a   D'Isa, Giuliana ^b   Mauriello, Clementina ^a   Varra, Michela ^b   De Santis, Pasquale ^a   Mayol, Luciano ^b   Savino, Maria ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

DNA triple helix; hTERT promoter; Perylene derivative DAPER; Telomerase inhibition; Triplex and duplex DAPER complexes; Triplex forming oligonucleotide

Indexed keywords

DOUBLE STRANDED DNA; N,N' BIS[3,3' (DIMETHYLAMINO)PROPYLAMINE] 3,4,9,10 PERYLENETETRACARBOXYLIC ACID DIIMIDE; NUCLEASE; OLIGONUCLEOTIDE; PERYLENE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CHROMATIN; CIRCULAR DICHROISM; DRUG BINDING; GENE; GENE SEQUENCE; HUMAN TELOMERASE REVERSE TRANSCRIPTASE GENE; NUCLEOSOME; PRIORITY JOURNAL; PROMOTER REGION; THERMODYNAMICS; TRIPLE HELIX;

BASE SEQUENCE; BINDING SITES; HUMANS; IMIDES; NUCLEIC ACID CONFORMATION; PERYLENE; PROMOTER REGIONS (GENETICS); SOLUBILITY; TELOMERASE; THERMODYNAMICS;

EID: 34347214448     PISSN: 03014622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpc.2007.05.009     Document Type: Article

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