Selective inhibition of transcription of the Ets2 gene in prostate cancer cells by a triplex-forming oligonucleotide

Nucleic Acids Research

Volumn 31, Issue 3, 2003, Pages 833-843

  Carbone, Giuseppina M ^a,b   McGuffie, Eileen M ^a   Collier, Angela ^a   Catapano, Carlo V ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3; TRIPLEX FORMING OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

BINDING AFFINITY; CANCER CELL; COMPLEX FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG BINDING SITE; DRUG DESIGN; DRUG PROTEIN BINDING; GENE EXPRESSION REGULATION; GENE MUTATION; GENE REPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; PROTEIN FAMILY; REVIEW; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; DNA; DNA-BINDING PROTEINS; HUMANS; MALE; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEIN C-ETS-2; PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RNA, NEOPLASM; SP1 TRANSCRIPTION FACTOR; SP2 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0037324315     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg198     Document Type: Review

References (46)

1. Sementchenko,V.I. and Watson,D.K. (2000) Ets target genes: past, present and future. Oncogene, 19, 6533-6548.
2. Yang,B.S., Hauser,C.A., Henkel,G., Colman,M.S., Van Beveren,C., Stacey,K.J., Hume,D.A., Maki,R.A. and Ostrowski,M.C. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol. Cell. Biol., 16, 538-547.
3. McCarthy,S.A., Chen,D., Yang,B.S., Garcia Ramirez,J.J., Cherwinski,H., Chen,X.R., Klagsbrun,M., Hauser,C.A., Ostrowski,M.C. and McMahon,M. (1997) Rapid phosphorylation of Ets-2 accompanies mitogen-activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1. Mol. Cell. Biol., 17, 2401-2412.
4. Gioeli,D., Mandell,J.W., Petroni,G.R., Frierson,H.F.,Jr and Weber,M.J. (1999) Activation of mitogen-activated protein kinase associated with prostate cancer progression. Cancer Res., 59, 279-284.
5. Seth,A., Watson,D.K., Blair,D.G. and Papas,T.S. (1989) c-ets-2 protooncogene has mitogenic and oncogenic activity. Proc. Natl Acad. Sci. USA, 86, 7833-7837.
6. Seth,A. and Papas,T.S. (1990) The c-ets-1 proto-oncogene has oncogenic activity and is positively autoregulated. Oncogene, 5, 1761-1767.
7. Wasylyk,C., Maira,S.M., Sobieszczuk,P. and Wasylyk,B. (1994) Reversion of Ras transformed cells by Ets transdominant mutants. Oncogene, 9, 3665-3673.
8. Galang,C.K., Der,C.J. and Hauser,C.A. (1994) Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites. Oncogene, 9, 2913-2921.
9. Gilliland,D.G. (2001) The diverse role of the ETS family of transcription factors in cancer. Clin. Cancer Res., 7, 451-453.
10. Liu,A.Y., Corey,E., Vessella,R.L., Lange,P.H., True,L.D., Huang,G.M., Nelson,P.S. and Hood,L. (1997) Identification of differentially expressed prostate genes: increased expression of transcription factor ETS-2 in prostate cancer. Prostate, 30, 145-153.
11. Sementchenko,V.I., Schweinfest,C.W., Papas,T.S. and Watson,D.K. (1998) ETS2 function is required to maintain the transformed state of human prostate cancer cells. Oncogene, 17, 2883-2888.
12. Sapi,E., Flick,M.B., Rodov,S. and Kacinski,B.M. (1998) Ets-2 transdominant mutant abolishes anchorage-independent growth and macrophage colony-stimulating factor-stimulated invasion by BT20 breast carcinoma cells. Cancer Res., 58, 1027-1033.
13. Neznanov,N., Man,A.K., Yamamoto,H., Hauser,C.A., Cardiff,R.D. and Oshima,R.G. (1999) A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice. Cancer Res., 59, 4242-4246.
14. de Nigris,F., Mega,T., Berger,N., Barone,M.V., Santoro,M., Viglietto,G., Verde,P. and Fusco,A. (2001) Induction of ETS-1 and ETS-2 transcription factors is required for thyroid cell transformation. Cancer Res., 61, 2267-2275.
15. Chan,P.P. and Glazer,P.M. (1997) Triplex DNA: fundamentals, advances, and potential applications for gene therapy. J. Mol. Med., 75, 267-282.
16. Praseuth,D., Guieysse,A.L. and Helene,C. (1999) Triple helix formation and the antigene strategy for sequence-specific control of gene expression. Biochim. Biophys. Acta, 1489, 181-206.
17. Winters,T.A. (2000) Gene targeted agents: new opportunities for rational drug development. Curr. Opin. Mol. Ther., 2, 670-681.
18. Wang,G., Seidman,M.M. and Glazer,P.M. (1996) Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair. Science, 271, 802-805.
19. Giovannangeli,C., Diviacco,S., Labrousse,V., Gryaznov,S., Charneau,P. and Helene,C. (1997) Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target. Proc. Natl Acad. Sci. USA, 94, 79-84.
20. Oh,D.H. and Hanawalt,P.C. (1999) Triple helix-forming oligonucleotides target psoralen adducts to specific chromosomal sequences in human cells. Nucleic Acids Res., 27, 4734-4742.
21. Vasquez,K.M., Narayanan,L. and Glazer,P.M. (2000) Specific mutations induced by triplex-forming oligonucleotides in mice. Science, 290, 530-533.
22. Faria,M., Wood,C.D., Perrouault,L., Nelson,J.S., Winter,A., White,M.R., Helene,C. and Giovannangeli,C. (2000) Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides. Proc. Natl Acad. Sci. USA, 97, 3862-3867.
23. Lebedeva,I. and Stein,C.A. (2001) Antisense oligonucleotides: promise and reality. Annu. Rev. Pharmacol. Toxicol., 41, 403-419.
24. Bates,P.J., Kahlon,J.B., Thomas,S.D., Trent,J.O. and Miller,D.M. (1999) Antiproliferative activity of G-rich oligonucleotides correlates with protein binding. J. Biol. Chem., 274, 26369-26377.
25. Scaggiante,B., Morassutti,C., Dapas,B., Tolazzi,G., Ustulin,F. and Quadrifoglio,F. (1998) Human cancer cell lines growth inhibition by GTn oligodeoxyribonucleotides recognizing single-stranded DNA-binding proteins. Eur. J. Biochem., 252, 207-215.
26. Benimetskaya,L., Berton,M., Kolbanovsky,A., Benimetsky,S. and Stein,C.A. (1997) Formation of a G-tetrad and higher order structures correlates with biological activity of the RelA (NF-kappaB p65) 'antisense' oligodeoxynucleotide. Nucleic Acids Res., 25, 2648-2656.
27. Burgess,T.L., Fisher,E.F., Ross,S.L., Bready,J.V., Qian,Y.X., Bayewitch,L.A., Cohen,A.M., Herrera,C.J., Hu,S.S., Kramer,T.B. et al. (1995) The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc. Natl Acad. Sci. USA, 92, 4051-4055.
28. Crooke,S.T. and Bennett,C.F. (1996) Progress in antisense oligonucleotide therapeutics. Annu. Rev. Pharmacol. Toxicol., 36, 107-129.
29. Mavrothalassitis,G.J., Watson,D.K. and Papas,T.S. (1990) The human ETS-2 gene promoter: molecular dissection and nuclease hypersensitivity. Oncogene, 5, 1337-1342.
30. Mavrothalassitis,G.J., Watson,D.K. and Papas,T.S. (1990) Molecular and functional characterization of the promoter of ETS2, the human c-ets-2 gene. Proc. Natl Acad. Sci. USA, 87, 1047-1051.
31. Mavrothalassitis,G.J. and Papas,T.S. (1991) Positive and negative factors regulate the transcription of the ETS2 gene via an oncogene-responsive-like unit within the ETS2 promoter region. Cell Growth Differ., 2, 215-224.
32. McGuffie,E.M. and Catapano,C.V. (2002) Design of a novel triple helix-forming oligodeoxyribonucleotide directed to the major promoter of the c-myc gene. Nucleic Acids Res., 30, 2701-2709.
33. Catapano,C.V., McGuffie,E.M., Pacheco,D. and Carbone,G.M. (2000) Inhibition of gene expression and cell proliferation by triple helix-forming oligonucleotides directed to the c-myc gene. Biochemistry, 39, 5126-5138.
34. Bonham,K. and Fujita,D.J. (1993) Organization and analysis of the promoter region and 5′ non-coding exons of the human c-src protooncogene. Oncogene, 8, 1973-1981.
35. Durland,R.H., Kessler,D.J., Gunnell,S., Duvic,M., Pettitt,B.M. and Hogan,M.E. (1991) Binding of triple helix forming oligonucleotides to sites in gene promoters. Biochemistry, 30, 9246-9255.
36. Tu,G.C., Cao,Q.N. and Israel,Y. (1995) Inhibition of gene expression by triple helix formation in hepatoma cells. J. Biol. Chem., 270, 28402-28407.
37. Aggarwal,B.B., Schwarz,L., Hogan,M.E. and Rando,R.F. (1996) Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells. Cancer Res., 56, 5156-5164.
38. McGuffie,E.M., Pacheco,D., Carbone,G.M. and Catapano,C.V. (2000) Antigene and antiproliferative effects of a c-myc-targeting phosphorothioate triple helix-forming oligonucleotide in human leukemia cells. Cancer Res., 60, 3790-3799.
39. Hacia,J.G., Wold,B.J. and Dervan,P.B. (1994) Phosphorothioate oligonucleotide-directed triple helix formation. Biochemistry, 33, 5367-5369.
40. Kim,H.G., Reddoch,J.F., Mayfield,C., Ebbinghaus,S., Vigneswaran,N., Thomas,S., Jones,D.E.,Jr and Miller,D.M. (1998) Inhibition of transcription of the human c-myc protooncogene by intermolecular triplex. Biochemistry, 37, 2299-2304.
41. Black,A.R., Black,J.D. and Azizkhan-Clifford,J. (2001) Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell Physiol., 188, 143-160.
42. Ritchie,S., Boyd,F.M., Wong,J. and Bonham,K. (2000) Transcription of the human c-Src promoter is dependent on Sp1, a novel pyrimidine binding factor SPy, and can be inhibited by triplex-forming oligonucleotides. J. Biol. Chem., 275, 847-854.
43. Roussel,M.F., Davis,J.N., Cleveland,J.L., Ghysdael,J. and Hiebert,S.W. (1994) Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1. Oncogene, 9, 405-415.
44. Michelotti,E.F., Tomonaga,T., Krutzsch,H. and Levens,D. (1995) Cellular nucleic acid binding protein regulates the CT element of the human c-myc protooncogene. J. Biol. Chem., 270, 9494-9499.
45. Kinniburgh,A.J., Firulli,A.B. and Kolluri,R. (1994) DNA triplexes and regulation of the c-myc gene. Gene, 149, 93-100.
46. Simonsson,T., Pecinka,P. and Kubista,M. (1998) DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res., 26, 1167-1172.