Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene

Anticancer Research

Volumn 21, Issue 3 B, 2001, Pages 1777-1787

  Ding Cheng Yang, ^a   Xien Peng Jiang, ^a   Elliott, R L ^a   Head, J F ^a  

^a The Mastology Research Institute   (United States)

Author keywords

Antisense oligonucleotide; Breast cancer; Human; RT PCR; Transferrin receptor

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DEFEROXAMINE; DNA; ENZYME INHIBITOR; HYDROXYUREA; IRON; IRON CHELATE; MESSENGER RNA; RIBONUCLEOTIDE REDUCTASE INHIBITOR; THYMIDINE; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR ANTISENSE OLIGONUCLEOTIDE PHOSPHOROTHIOATE; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; START CODON;

BREAST NEOPLASMS; CELL DIVISION; CELL SURVIVAL; DEFEROXAMINE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYUREA; IMMUNOHISTOCHEMISTRY; INHIBITORY CONCENTRATION 50; OLIGONUCLEOTIDES, ANTISENSE; RECEPTORS, TRANSFERRIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0034903090     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Regulation of transferrin receptor expression and control of cell growth
2. Transferrin receptor gene expression during rat liver regeneration
3. Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials
4. Transferrin and transferrin receptor in carcinoma of the breast
5. Transferrin receptor (TrfR) expression in breast carcinoma and its possible relationship to prognosis
6. Transferrin receptor mRNA and ferritin H-chain mRNA expression are associated with prognostic indicators for breast cancer
7. Human T lymphotopic virus I infection deregulates surface expression of the transferrin receptor
8. Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro
9. Primary structure of human transferrin receptor deduced from the mRNA sequence
10. Evolution of the functional human β-actin gene and its multi-pseudogene family: Conservation of noncoding regions and chromosomal dispersion of pseudogenes
11. Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation
12. Antitumor effect of deferoxamine on human hepatocellular carcinoma growing in athymic nude mice
13. The effect of the iron (III) chelator, desferioxamine, on iron and transferrin uptake by the human malignant melanoma cell
14. Effects of anti-transferrin receptor antibodies on the growth of neoplastic cells
15. Mechanism of growth inhibition by anti-transferrin receptor monoclonal antibodies
16. Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies
17. The use of RNAs complementary to specific mRNAs to regulate the expression of individual bacterial genes
18. Phenocopy of discoidin I-minus mutants by antisense transformation in dictyostelium
19. Inhibition of DNA synthesis by cross-linking the template to platinum-thiol derivatives of complementary oligonucleotides