A copper-binding site in the cytoplasmic domain of BACE1 identifies a possible link to metal homoeostasis and oxidative stress in Alzheimer's disease

Biochemical Society Transactions

Volumn 35, Issue 3, 2007, Pages 571-573

  Dingwall, C ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

site amyloid precursor protein cleaving enzyme 1 (BACE1); Alzheimer's disease; Amyloid; Aspartic proteinase; Copper; Proteinase

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BACE1 ENZYME; BETA SECRETASE; CHAPERONE; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTEINE; GAMMA SECRETASE; IRON; UNCLASSIFIED DRUG; ZINC;

ALZHEIMER DISEASE; BINDING SITE; CONFERENCE PAPER; ENZYME BINDING; HOMEOSTASIS; METAL BINDING; OXIDATIVE STRESS; PRIORITY JOURNAL; SENILE PLAQUE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BRAIN; COPPER; HOMEOSTASIS; HUMANS; METALS; MICE; MOLECULAR CHAPERONES; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; SUPEROXIDE DISMUTASE;

EID: 34250834446     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0350571     Document Type: Conference Paper

References (23)

1. Crichton, R.R. and Ward, R.J. (2006) Metal-Based Neurodegeneration, John Wiley & Sons Ltd, New Jersey
2. Hardy, J. (2006) J. Alzheimer's Dis. 9 (Suppl.), 151-153
3. Bush, A.I. (2003) Alzheimer Dis. Assoc. Disord. 17, 147-150
4. Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C.L. and Beyreuther, K. (1996) Science 271, 1406-1409
5. Hutchinson, R.W., Cox, A.G., McLeod, C.W., Marshall, P.S., Harper, A., Dawson, E.L. and Howlett, D.R. (2005) Anal. Biochem. 346, 225-233
6. White, A.R., Reyes, R., Mercer, J.F., Camakaris, J., Zheng, H., Bush, A.I., Multhaup, G., Beyreuther, K., Masters, C.L. and Cappai, R. (1999) Brain Res. 842, 439-444
7. Cherny, R.A., Atwood, C.S., Xilinas, M.E., Gray, D.N., Jones, W.D., McLean, C.A., Barnham, K.J., Volitakis, I., Fraser, F.W., Kim, Y. et al. (2001) Neuron 30, 665-676
8. White, A.R., Du, T., Laughton, K.M., Volitakis, I., Sharples, R.A., Xilinas, M.E., Hoke, D.E., Holsinger, R.M., Evin, G., Cherny, R.A. et al. (2006) J. Biol. Chem. 281, 17670-17680
9. Erreger, K. and Traynelis, S.F. (2005) J. Physiol. 569, 381-393
10. Harter, D.E. and Barnea, A. (1988) Synapse 2, 412-415
11. Kay, A.R. (2006) Trends Neurosci. 29, 200-206
12. Cirrito, J.R., Yamada, K.A., Finn, M.B., Sloviter, R.S., Bales, K.R., May, P.C., Schoepp, D.D., Paul, S.M., Mennerick, S. and Holtzman, D.M. (2005) Neuron 48, 913-922
13. Zlokovic, B.V. (2004) J. Neurochem. 89, 807-811
14. Huse, J.T., Pijak, D.S., Leslie, G.J., Lee, V.M. and Doms, R.W. (2000) J. Biol. Chem. 275, 33729-33737
15. Walter, J., Fluhrer, R., Hartung, B., Willem, M., Kaether, C., Capell, A., Lammich, S., Multhaup, G. and Haass, C. (2001) J. Biol. Chem. 276, 14634-14641
16. Benjannet, S., Elagoz, A., Wickham, L., Mamarbachi, M., Munzer, J.S., Basak, A., Lazure, C., Cromlish, J.A., Sisodia, S., Checler, F. et al. (2001) J. Biol. Chem. 276, 10879-10887
17. Angeletti, B., Waldron, K.J., Freeman, K.B., Bawagan, H., Hussain, I., Miller, C.C., Lau, K.F., Tennant, M.E., Dennison, C., Robinson, N.J. and Dingwall, C. (2005) J. Biol. Chem. 280, 17930-17937
18. Lippard, S.J. (1999) Science 284, 748-749
19. Furukawa, Y., Torres, A.S. and O'Halloran, T.V. (2004) EMBOJ. 23, 2872-2881
20. Rothstein, J.D., Dykes-Hoberg, M., Corson, L.B., Becker, M., Cleveland, D.W., Price, D.L., Culotta, V.C. and Wong, P.C. (1999) J. Neurochem. 72, 422-429
21. Lamb, A.L., Torres, A.S., O'Halloran, T.V. and Rosenzweig, A.C. (2001) Nat. Struct. Biol. 8, 751-755
22. McLoughlin, D.M., Standen, C.L., Lau, K.F., Ackerley, S., Bartnikas, T.P., Gitlin, J.D. and Miller, C.C. (2001) J. Biol. Chem. 276, 9303-9307
23. Miller, C.C., McLoughlin, D.M., Lau, K.F., Tennant, M.E. and Rogelj, B. (2006) Trends Neurosci. 29, 280-285