Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors

Journal of Physiology

Volumn 569, Issue 2, 2005, Pages 381-393

  Erreger, Kevin ^a,b   Traynelis, Stephen F ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMIC ACID; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; PROTEIN SUBUNIT; ZINC;

ACTION POTENTIAL; ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DATA ANALYSIS; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; STEADY STATE; CHANNEL GATING; CONCENTRATION (PARAMETERS); EMBRYO; PH; RECEPTOR BINDING;

ALLOSTERIC REGULATION; BINDING SITES; CELL LINE; DATA INTERPRETATION, STATISTICAL; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; GLYCINE; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS; ZINC;

EID: 29244474382     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.095497     Document Type: Article

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