The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain

Journal of Neurochemistry

Volumn 72, Issue 1, 1999, Pages 422-429

  Rothstein, Jeffrey D ^a   Dykes Hoberg, Margaret ^a   Corson, Laura B ^a,b   Becker, Mark ^a   Cleveland, Don W ^b,c   Price, Donald L ^a   Culotta, Valeria Cizewski ^a   Wong, Phillip C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Amyotrophic lateral sclerosis; CCS; Copper chaperone; Motor neuron; Superoxide dismutase

Indexed keywords

ANTIOXIDANT; CHAPERONE; COPPER; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN; GENE MUTATION; HUMAN; HUMAN CELL; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SPINAL CORD;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIBODIES; ASTROCYTES; BRAIN CHEMISTRY; CHAPERONINS; COPPER; HUMANS; MICE; MOLECULAR CHAPERONES; MOTOR NEURONS; NERVOUS SYSTEM; RATS; SUPEROXIDE DISMUTASE;

ANIMALIA; MAMMALIA; RODENTIA;

EID: 0032901111     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0720422.x     Document Type: Article

References (25)

1. Bensimon G., Lacomblez L., Meininger V., and the ALS/Riluzole Study Group (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. N. Engl. J. Med. 330, 585-591.
2. Blackstone C. D., Levey A. I., Martin L. J., Price D. L., and Huganir R. L. (1992) Immunological detection of glutamate receptor subtypes in human central nervous system. Ann. Neurol. 31, 680-683.
3. Borchelt D. R., Lee M. K., Slunt H. H., Guarnieri M., Xu Z.-S., Wong P. C., Brown R. H. Jr., Price D. L., Sisodia S. S., and Cleveland D. W. (1994) Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc. Natl. Acad. Sci. USA 91, 8292-8296.
4. Bruijn L. I., Becher M. W., Lee M. K., Anderson K. L., Jenkins N. A., Copeland N. G., Sisodia S. S., Rothstein J. D., Borchelt D. R., Price D. L., and Cleveland D. W. (1997) ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron 18, 327-338.
5. Corson L. B., Strain J. J., Culotta V. C., and Cleveland D. W. (1998) Chaperone-facilitated copper binding is a property common to several classes of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants. Proc. Natl. Acad. Sci. USA 95, 6361-6366.
6. Culotta V. C., Klomp L. W. J., Strain J., Casareno R. L. B., Krems B., and Gitlin J. D. (1997) The copper chaperone for superoxide dismutase. J. Biol. Chem. 272, 23469-23472.
7. Fridovich I. (1986) Superoxide dismutases. Adv. Enzymol. Relat. Areas Mol. Biol. 58, 61-97.
8. Glerum D. M., Shtanko A., and Tzagoloff A. (1996a) SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J. Biol. Chem. 271, 20531-20535.
9. Glerum D. M., Shtanko A., and Tzagoloff A. (1996b) Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase. J. Biol. Chem. 271, 14504-14509.
10. Gurney M. E., Pu H., Chiu A. Y., Dal Canto M. C., Polchow C. Y., Alexander D. D., Caliendo J., Hentati A., Kwon Y. W., Deng H.-X., Chen W., Zhai P., Sufit R. L., and Siddique T. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 264, 1772-1775.
11. Harris Z. L. and Gitlin J. D. (1996) Genetic and molecular basis for copper toxicity. Am. J. Clin. Nutr. 63, 836S-841S.
12. Klomp L. W. J., Lin S.-J., Yuan D. S., Klausner R. D., Culotta V. C., and Gitlin J. D. (1997) Identification and functional expression of HAHI, a novel human gene involved in copper homeostasis. J. Biol. Chem. 272, 9221-9226.
13. Kuncl R. W., Crawford T. O., Rothstein J. D., and Drachman D. B. (1992) Motor neuron diseases, in Diseases of the Nervous System (Asbury A. K., McKhann G. M., and McDonald W. I., eds), pp. 1179-1208. W. B. Saunders, Philadelphia.
14. Lacomblez L., Bensimon G., Leigh P. N., Guillet P., and Meininger V. (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Lancet 347, 1425-1431.
15. Lin S.-J., and Culotta V. C. ( 1995) The ATX1 gene of Saccharomyces cerevisiae encodes a small metal homeostasis factor that protects cells against reactive oxygen toxicity. Proc. Natl. Acad. Sci. USA 92, 3784-3788.
16. Miller R. G., Gelinas D., Moore D., Mendoza M., Quien A., Young L., Armon C., Linda L., Barohn R., Bryan W., Bromberg M., Petajan J., Neville H., Ringel S., Parry G., Ravits J., Ross M., and Leiderman D. (1996) A placebo-controlled trial of gabapentin in amyotrophic lateral sclerosis. Neurology 46, A469.
17. Pardo C. A., Xu Z., Borchelt D. R., Price D. L., Sisodia S. S., and Cleveland D. W. (1995) Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc. Natl. Acad. Sci. USA 92, 954-958.
18. Pufahl R. A., Singer C. P., Peariso K. L., Lin S.-J., Schmidt P. J., Fahrni C. J., Culotta V. C., Penner-Hahn J. E., and O'Halloran T. V. (1997) Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science 278, 853-856.
19. Ripps M. E., Huntley G. W., Hof P. R., Morrison J. H., and Gordon J. W. (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 92, 689-693.
20. Rothstein J. D., Martin L., Levey A. I., Dykes-Hoberg M., Jin L., Wu D., Nash N., and Kuncl R. W. (1994) Localization of neuronal and glial glutamate transporters. Neuron 13, 713-725.
21. Rowland L. P. (1994) Natural history and clinical features of amyotrophic lateral sclerosis and related motor neuron diseases, in Neurodegenerative Diseases (Calne D. B., ed), pp. 507-521. W. B. Saunders, Philadelphia.
22. Siddique T. and Deng H. X. (1996) Genetics of amyotrophic lateral sclerosis. Hum. Mol. Genet. 5, 1465-1470.
23. Solomon E. I. and Lowery M. D. (1993) Electronic structure contributions to function in bioinorganic chemistry. Science 259, 1575-1581.
24. Valentine J. S. and Gralla E. B. (1997) Delivering copper inside yeast and humans. Science 278, 817-818.
25. Wong P. C., Pardo C. A., Borchelt D. R., Lee M. K., Copeland N. G., Jenkins N. A., Sisodia S. S., Cleveland D. W., and Price D. L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14, 1105-1116.