Engineered polymeric micelles: A novel tool for solubilization and stabilization of membrane protein targets for proteomics and drug discovery

American Laboratory

Volumn 37, Issue 24, 2005, Pages 19-22

  Trubetskoy, Vladimir S ^a   Burke, Thomas J ^b  

^a Quintessence Biosciences Inc   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 33744802908     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (7)

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2. Hopkins AL, Groom CR. Target analysis: a priori assessment of druggability. Ernst Schering Res Found Workshop 2003; 42:11-17.
3. Bledi Y, Inberg A, Linial M. PROCEED: a proteomic method for analysing plasma membrane proteins in living mammalian cells. Brief Funct Genomic Proteomic 2003; 2(3):254-65.
4. Zheng W, Spencer RH, Kiss L. High throughput assay technologies for ion channel drug discovery. Assay Drug Dev Technol 2004; 2(5):543-52.
5. Kurkela M, Garcia-Horsman JA, Luukkanen L, et al. Expression and characterization of recombinant human UDP-glucuronosyltransferases (UGTs). UGT1A9 is more resistant to detergent inhibition than other UGTs and was purified as an active dimeric enzyme. J Biol Chem 2003; 278(6):3536-44.
6. McGregor CL, Chen L, Pomroy NC, et al. Lipopeptide detergents designed for the structural study of membrane proteins. Nat Biotechnol 2003 ; 21(2): 171-6.
7. Trubetskoy VS. Polymeric micelles as carriers of diagnostic agents. Adv Drug Deliv Rev 1999; 37(1-3):81-8.