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The sole literature precedent: Herbert, B. Arch. Pharm. 1982, 315, 684.
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34250834455
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The bisvinylphosphate 3 is stable for several months at 4°C under argon atmosphere.
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The bisvinylphosphate 3 is stable for several months at 4°C under argon atmosphere.
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34250828540
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Addition of HMPA, which stabilizes the formed anion, was in most cases useful to improve the reaction's yield.
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Addition of HMPA, which stabilizes the formed anion, was in most cases useful to improve the reaction's yield.
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43
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34250897436
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Diederich, F, Stang, P. J, Eds, Wiley-VCH: New York, Chapter 5
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Sonogashira, K.1
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47
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34250878476
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In the case of compounds 6c and 6k, only 1.5 equiv of n-BuLi (instead of 2 equiv) was used in order to preclude the reaction of the base directly on the 3,4,5-trimethoxyaldehyde. The obtained corresponding alcohol is difficult to separate effectively from the desired trisubstituted compound
-
In the case of compounds 6c and 6k, only 1.5 equiv of n-BuLi (instead of 2 equiv) was used in order to preclude the reaction of the base directly on the 3,4,5-trimethoxyaldehyde. The obtained corresponding alcohol is difficult to separate effectively from the desired trisubstituted compound.
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48
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34250838097
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The regioselective functionalization of the oxazine 5 at the C-3 position was confirmed by the following reaction. The analytical data of compound 11 are depicted in the Experimental Section. (Chemical Equation Presented)
-
The regioselective functionalization of the oxazine 5 at the C-3 position was confirmed by the following reaction. The analytical data of compound 11 are depicted in the Experimental Section. (Chemical Equation Presented)
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