A simple solid phase diversity linker strategy using enol phosphonates

Organic and Biomolecular Chemistry

Volumn 2, Issue 19, 2004, Pages 2725-2727

  Campbell, Ian B ^a   Guo, Jun ^b   Jones, Edward ^b   Steel, Patrick G ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CATALYSTS; NUCLEAR MAGNETIC RESONANCE; PHENOLS; PHOSPHATES; POLYSTYRENES; SYNTHESIS (CHEMICAL);

BORONIC ACIDS; PHOSPHONATES; SOLID PHASE SYNTHESIS; SUZUKI REACTIONS;

RESINS;

LATEOLABRAX JAPONICUS;

CROSS LINKING REAGENT; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY;

CROSS-LINKING REAGENTS; MOLECULAR STRUCTURE; PHOSPHONIC ACIDS;

EID: 6344240542     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b411111g     Document Type: Article

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36. Phosphonate linkers have been reported for use in other cleavage strategies. See for example C. R. Johnson and B. R. Zhang, Tetrahedron Lett., 1995, 36, 9253; X. D. Cao and A. M. M. Mjalli, Tetrahedron Lett., 1996 37 6073; C. Z. Zhang and A. M. M. Mjalli, Tetrahedron Lett., 1996, 37, 5457; K. C. Nicolaou, J. Pastor, N. Winssinger and F. Murphy, J. Am. Chem. Soc., 1998, 120, 5132.
37. Phosphonate linkers have been reported for use in other cleavage strategies. See for example C. R. Johnson and B. R. Zhang, Tetrahedron Lett., 1995, 36, 9253; X. D. Cao and A. M. M. Mjalli, Tetrahedron Lett., 1996 37 6073; C. Z. Zhang and A. M. M. Mjalli, Tetrahedron Lett., 1996, 37, 5457; K. C. Nicolaou, J. Pastor, N. Winssinger and F. Murphy, J. Am. Chem. Soc., 1998, 120, 5132.
38. Phosphonate linkers have been reported for use in other cleavage strategies. See for example C. R. Johnson and B. R. Zhang, Tetrahedron Lett., 1995, 36, 9253; X. D. Cao and A. M. M. Mjalli, Tetrahedron Lett., 1996 37 6073; C. Z. Zhang and A. M. M. Mjalli, Tetrahedron Lett., 1996, 37, 5457; K. C. Nicolaou, J. Pastor, N. Winssinger and F. Murphy, J. Am. Chem. Soc., 1998, 120, 5132.
39. Phosphonate linkers have been reported for use in other cleavage strategies. See for example C. R. Johnson and B. R. Zhang, Tetrahedron Lett., 1995, 36, 9253; X. D. Cao and A. M. M. Mjalli, Tetrahedron Lett., 1996 37 6073; C. Z. Zhang and A. M. M. Mjalli, Tetrahedron Lett., 1996, 37, 5457; K. C. Nicolaou, J. Pastor, N. Winssinger and F. Murphy, J. Am. Chem. Soc., 1998, 120, 5132.
40. In all cases the 2-arylenamide products 15 are isolated as rotomeric mixtures interconvertable at 60°C as ascertained by simple VT NMR studies.