Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line

Nephron - Experimental Nephrology

Volumn 103, Issue 3, 2006, Pages

  Wen, Yu Jie ^a   Su, Tao ^a   Tang, Jia Wei ^a   Zhang, Cui Ying ^b   Wang, Xuang ^b   Cai, Shao Qing ^b   Li, Xiao Mei ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Aristolochia contorta; Aristolochic acid nephropathy; Human renal proximal tubular epithelial cells; Phenanthrenes; Renal cytotoxicity of phenanthrenes

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 7 METHOXYARISTOLOLACTAM IV; ARISTOLOCHIA CONTORTA EXTRACT; ARISTOLOCHIC ACID; ARISTOLOCHIC ACID I; ARISTOLOLACTAM IVA; LACTATE DEHYDROGENASE; PHENANTHRENE DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARISTOLOCHIA; ARISTOLOCHIA CONTORTA; ARISTOLOCHIC ACID NEPHROPATHY; ARTICLE; CELL ASSAY; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; INTERSTITIAL NEPHRITIS; KIDNEY PROXIMAL TUBULE; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

ARISTOLOCHIA; ARISTOLOCHIC ACIDS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; HUMANS; KIDNEY TUBULES, PROXIMAL; L-LACTATE DEHYDROGENASE; MICROSCOPY, ELECTRON; PHENANTHRENES; PLANT EXTRACTS; TETRAZOLIUM SALTS;

EID: 33745462527     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000092194     Document Type: Article

References (46)

1. Li X, Wang H: Aristolochic acid nephropathy: what we know and what we have to do. Nephrology (Carlton) 2004;9:109-111.
2. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, Vanhaelen-Fastre R, et al: Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet 1993;341:387-391.
3. Cosyns JP, Jadoul M, Squifflet JP, De Plaen JF, Ferluga D, van Ypersele de Strihou C: Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 1994;45:1680-1688.
4. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM, van Ypersele de Strihou C: Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy? Kidney Int 2001;59:2164-2173.
5. Debelle FD, Nortier JL, De Prez EG, Garbar CH, Vienne AR, Salmon IJ, Deschodt-Lanckman MM, Vanherweghem JL: Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol 2002;13:431-436.
6. Gillerot G, Jadoul M, Arlt VM, van Ypersele de Strihou C, Schmeiser HH, But PP, Bieler CA, Cosyns JP: Aristolochic acid nephropathy in a Chinese patient: time to abandon the term 'Chinese herbs nephropathy'? Am J Kidney Dis 2001;38:E26.
7. Sato N, Takahashi D, Chen SM, Tsuchiya R, Mukoyama T, Yamagata S, Ogawa M, Yoshida M, Kondo S, Satoh N, Ueda S: Acute nephrotoxicity of aristolochic acids in mice. J Pharm Pharmacol 2004;56:221-229.
8. Arlt VM, Stiborova M, Schmeiser HH: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis 2002;17:265-277.
9. Schwetz BA: From the Food and Drug Administration. JAMA 2002;287:1103.
10. Mengs U: Acute toxicity of aristolochic acid in rodents. Arch Toxicol 1987;59:328-331.
11. Lord GM, Tagore R, Cook T, Gower P, Pusey CD: Nephropathy caused by Chinese herbs in the UK. Lancet 1999;354:481-482.
12. Lee S, Lee T, Lee B, Choi H, Yang M, Ihm CG, Kim M: Fanconi's syndrome and subsequent progressive renal failure caused by a Chinese herb containing aristolochic acid. Nephrology (Carlton) 2004;9:126-129.
13. Pena JM, Borras M, Ramos J, Montoliu J: Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996;11:1359-1360.
14. Cosyns JP, Goebbels RM, Liberton V, Schmeiser HH, Bieler CA, Bernard AM: Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats. Arch Toxicol 1998;72:738-743.
15. Stiborova M, Frei E, Sopko B, Wiessler M, Schmeiser HH: Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 2002;23:617-625.
16. Nortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereerstraeten P, Vanherweghem JL: Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 2000;342:1686-1692.
17. Krumbiegel G, Hallensleben J, Mennicke WH, Rittmann N, Roth HJ: Studies on the metabolism of aristolochic acids I and II. Xenobiotica 1987;17:981-991.
18. Rietjens IM, Martena MJ, Boersma MG, Spiegelenberg W, Alink GM: Molecular mechanisms of toxicity of important food-borne phytotoxins. Mol Nutr Food Res 2005;49:131-158.
19. Li X, Yang L, Yu Y: An analysis of the clinical and pathological characteristics of mu-tong (a Chinese herb) induced tubulointerstitial nephropathy (in Chinese). Zhonghua Nei Ke Za Zhi 2001;40:681-687.
20. Martinez MC, Nortier J, Vereerstraeten P, Vanherweghem JL: Progression rate of Chinese herb nephropathy: impact of Aristolochia fangchi ingested dose. Nephrol Dial Transplant 2002;17:408-412.
21. Reginster F, Jadoul M, van Ypersele de Strihou C: Chinese herbs nephropathy presentation, natural history and fate after transplantation. Nephrol Dial Transplant 1997;12:81-86.
22. Ng YY, Yu S, Chen TW, Wu SC, Yang AH, Yang WC: Interstitial renal fibrosis in a young woman: association with a Chinese preparation given for irregular menses. Nephrol Dial Transplant 1998;13:2115-2117.
23. Yang CS, Lin CH, Chang SH, Hsu HC: Rapidly progressive fibrosing interstitial nephritis associated with Chinese herbal drugs. Am J Kidney Dis 2000;35:313-318.
24. Chang CH, Wang YM, Yang AH, Chiang SS: Rapidly progressive interstitial renal fibrosis associated with Chinese herbal medications. Am J Nephrol 2001;21:441-448.
25. Kabanda A, Jadoul M, Lauwerys R, Bernard A, van Ypersele de Strihou C: Low molecular weight proteinuria in Chinese herbs nephropathy. Kidney Int 1995;48:1571-1576.
26. Depierreux M, Van Damme B, Vanden Houte K, Vanherweghem JL: Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs. Am J Kidney Dis 1994;24:172-180.
27. Nortier JL, Deschodt-Lanckman MM, Simon S, Thielemans NO, de Prez EG, Depierreux MF, Tielemans CL, Richard C, Lauwerys RR, Bernard AM, Vanherweghem JL: Proximal tubular injury in Chinese herbs nephropathy: monitoring by neutral endopeptidase enzymuria. Kidney Int 1997;51:288-293.
28. Lebeau C, Arlt VM, Schmeiser HH, Boom A, Verroust PJ, Devuyst O, Beauwens R: Aristolochic acid impedes endocytosis and induces DNA adducts in proximal tubule cells. Kidney Int 2001;60:1332-1342.
29. Balachandran P, Wei F, Lin RC, Khan IA, Pasco DS: Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int 2005;67:1797-1805.
30. Lebeau C, Debelle FD, Arlt VM, Pozdzik A, De Prez EG, Phillips DH, Deschodt-Lanckman MM, Vanherweghem JL, Nortier JL: Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies. Nephrol Dial Transplant 2005;20:2321-2332.
31. Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B: HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Kidney Int 1994;45:48-57.
32. Koul S, Fu S, Koul H: Oxalate exposure promotes reinitiation of the DNA synthesis and apoptosis of HK-2 cells, a line of human renal epithelial cells. Ann NY Acad Sci 2003;1010:292-295.
33. Ortiz A, Justo P, Sanz A, Melero R, Caramelo C, Guerrero MF, Strutz F, Muller G, Barat A, Egido J: Tubular cell apoptosis and cidofovir-induced acute renal failure. Antivir Ther 2005;10:185-190.
34. Zager RA: Polyene antibiotics: relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content. Am J Kidney Dis 2000;36:238-249.
35. Li B, Li XM, Zhang CY, Wang X, Cai SQ: Cellular mechanism of renal proximal tubular epithelial cell injury induced by aristolochic acid I and aristololactam I. Beijing Da Xue Xue Bao 2004;36:36-40.
36. Li B, Li XM, Zhang CY, Wang X, Cai SQ: Injury in renal proximal tubular epithelial cells induced by aristololactam I (in Chinese). Zhongguo Zhong Yao Za Zhi 2004;29:78-83.
37. Bergmeyer HU, Bernt E, Bergmeyer HU: Lactate dehydrogenase: UV assay with pyruvate and NADH; in Methods of Enzymatic Analysis. New York, Academic Press, 1974, vol 2, pp 574-579.
38. Sauvant MP, Pepin D, Bohatier J, Groliere CA, Guillot J: Toxicity assessment of 16 inorganic environmental pollutants by six bioassays. Ecotoxicol Environ Saf 1997;37:131-140.
39. Hasan CM, Asha KN, Rashid MA: Aristolactams from the stem bark of Uvaria hamiltonii. Biochem Syst Ecol 2001;29:207-208.
40. Jumana S, Hasan CM, Rashid MA: Alakaloids from the stem bark of Miliusa velutina. Biochem Syst Ecol 2000;28:483-485.
41. Zhang YJ, Kong M, Chen RY, Yu DQ: Alkaloids from the roots of goniothalamus griffithii. J Nat Prod 1999;62:1050-1052.
42. Sun NJ, Antoun M, Chang CJ, Cassady JM: New cytotoxic aristolactams from Pararistolochia flos-avis. J Nat Prod 1987;50:843-846.
43. Kim SK, Ryu SY, No J, Choi SU, Kim YS: Cytotoxic alkaloids from Houttuynia cordata. Arch Pharm Res 2001;24:518-521.
44. Couture A, Deniau E, Grandclaudon P, Rybalko-Rosen H, Leonce S, Pfeiffer B, Renard P: Synthesis and biological evaluation of aristolactams. Bioorg Med Chem Lett 2002;12:3557-3559.
45. Cosyns JP: Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date. Drug Saf 2003;26:33-48.
46. Nortier JL, Vanherweghem JL: Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). Toxicology 2002;181-182:577-580.