Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 16, 2007, Pages 5406-5416

  Brizzi, Antonella ^a   Cascio, Maria Grazia ^b,c   Brizzi, Vittorio ^a   Bisogno, Tiziana ^b   Dinatolo, Maria Teresa ^a   Martinelli, Adriano ^d   Tuccinardi, Tiziano ^d   Di Marzo, Vincenzo ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF SALERNO   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Anandamide; Cannabinoid receptors; Docking; Endocannabinoids

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; LIGAND;

ALKYLATION; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIELECTRIC CONSTANT; GENETIC ALGORITHM; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; MOLECULAR RECOGNITION; MONTE CARLO METHOD; NONHUMAN; PHARMACOPHORE; QUALITATIVE ANALYSIS; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CHEMISTRY, PHYSICAL; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, CANNABINOID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34250693214     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.060     Document Type: Article

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