Telomere length, telomere-binding proteins, and DNA damage signaling

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 65, Issue , 2000, Pages 275-279

  Hemann, M T ^a   Hackett, J ^a   Ijpma, A ^a   Greider, C W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA BINDING PROTEIN; TELOMERASE; TELOMERE BINDING PROTEIN;

APOPTOSIS; CHROMOSOME; CONFERENCE PAPER; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME ACTIVITY; GENE REARRANGEMENT; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TANDEM REPEAT; TELOMERE; ANIMAL; BIOLOGICAL MODEL; GENETICS; HUMAN; METABOLISM; REVIEW; SACCHAROMYCES CEREVISIAE; ULTRASTRUCTURE; ARTICLE; DNA DAMAGE RESPONSE; TELOMERE LENGTH; TELOMERE SHORTENING;

ANIMAL; DNA DAMAGE; HUMAN; MODELS, GENETIC; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.; TELOMERE; TELOMERE-BINDING PROTEINS;

EID: 0034437343     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2000.65.275     Document Type: Conference Paper

References (50)

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2. Ku binds telomeric DNA in vitro
3. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
4. Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing
5. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
6. p53 deficiency rescues the adverse effects of telomere loss in vivo and cooperates with telomere dysfunction to accelerate carcinogenesis
7. A human telomeric protein
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9. Fission yeast Tazl protein is required for meiotic telomere clustering and recombination
10. Regulation of telomere length and function by a Myb-domain protein in fission yeast
11. Single-stranded DNA arising at telomeres in cdc 13 mutants may constitute a specific signal for the RAD9 checkpoint
12. Yeast Ku as a regulator of chromosomal DNA end structure
13. Inhibition of telomerase limits the growth of human cancer cells
14. Telomeres shorten during ageing of human fibroblasts
15. Ku is associated with the telomere in mammals
16. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
17. TIN2, a new regulator of telomere length in human cells
18. Block in anaphase chromosome separation caused by a telomerase template mutation
19. Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres
20. Essential role of mouse telomerase in highly proliferative organs
21. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
22. Identification of human Rap1: Implications for telomere evolution
23. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
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25. An alternative pathway for yeast telomere maintenance rescues est1- senescence
26. A mutant with a defect in telomere elongation leads to senescence in yeast
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28. The fusion of broken ends of sister half-chromatids following chromatid breakage at meiotic anaphases
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30. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
31. The remaking of chromosomes
32. Defective meiosis in telomere-silencing mutants of Schizosaccharomyces pombe
33. Cdc 13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
34. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
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36. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
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38. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
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40. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
41. Targeted breakage of paracentromeric heterochromatin induces chromosomal instability
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45. Silencing factors participate in DNA repair and recombination in Saccharomyees cerevisiae
46. Control of telomere length by the human telomeric protein TRF1
47. TRF2 protects human telomeres from end-to-end fusions
48. A novel Rap 1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae
49. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
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