Promoter hypomethylation of protease-activated receptor 2 associated with carcinogenesis in the stomach

Journal of Gastroenterology and Hepatology (Australia)

Volumn 22, Issue 6, 2007, Pages 943-948

  Arisawa, Tomiyasu ^a,b   Tahara, Tomomitsu ^a   Shibata, Tomoyuki ^a   Nagasaka, Mitsuo ^a   Nakamura, Masakatsu ^a   Kamiya, Yoshio ^a   Fujita, Hiroshi ^a   Takagi, Tamaki ^a   Hasegawa, Shin ^a   Wang, Fang Yu ^a   Hirata, Ichiro ^a   Nakano, Hiroshi ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE   (Japan)

Author keywords

Chronic gastritis; Gastric cancer; Promoter methylation; Protease activated receptor 2

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2;

ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; FEMALE; GENDER; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION; STOMACH CANCER; STOMACH MUCOSA;

EID: 34250325945     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.04847.x     Document Type: Article

References (31)

1. Hirahara F, Miyagi Y, Miyagi E et al. Trypsinogen expression in human ovarian carcinomas. Int. J. Cancer 1995 63 : 176 81.
2. Kawano N, Osawa H, Ito T et al. Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin (ogen) in lung neoplasms: an immunohistochemical study. Hum. Pathol. 1997 28 : 613 22.
3. Miyata S, Miyagi Y, Koshikawa N et al. Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells. Clin. Exp. Metastasis 1998 16 : 613 22.
4. Williams SJ, Gotley DC, Antalis TM. Human trypsinogen in colorectal cancer. Int. J. Cancer 2001 93 : 67 73.
5. Dery O, Corvera CU, Steinhoff M, Bunnett NW. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 1998 274 : C1429 52.
6. Schmildlin F, Bunnett NW. Protease-activated receptors: how proteases signal to cells. Curr. Opin. Pharmacol. 2001 1 : 575 82.
7. Molino M, Barnathan ES, Numerof R et al. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 1997 272 : 4043 9.
8. Molino M, Woolkalis MJ, Reavey-Cantwell J et al. Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment. J. Biol. Chem. 1997 272 : 11133 41.
9. Howells GL, Macey MG, Chinni C et al. Proteinase-activated receptor-2: expression by human neutrophils. J. Cell Sci. 1997 110 : 881 7.
10. Bertog M, Letz B, Kong W et al. Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. J. Physiol. 1999 521 : 3 17.
11. Fujimoto D, Hirono Y, Goi T, Katayama K, Hirose K, Yamaguchi A. Expression of protease activated receptor-2 (PAR-2) in gastric cancer. J. Surg. Oncol. 2006 93 : 139 44.
12. Yamashita K, Mimori K, Inoue H, Mori M, Sidransky D. A tumor-supressive role for trypsin in human cancer progression. Cancer Res. 2003 63 : 6575 8.
13. Arisawa T, Tahara T, Shibata T et al. A F240S polymorphism of protease-activated receptor 2 (PAR-2) is not detected in Japanese population with upper gastrointestinal symptoms. J. Clin. Biochem. Nutr. 2006 39 : 98 101.
14. Baylin SB, Herman JG, Graff JR, Vertino PM, Issa JP. Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv. Cancer Res. 1998 72 : 141 96.
15. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet 2002 3 : 415 28.
16. Oue N, Sentani K, Yokozaki H, Kitadai Y, Ito R. Yasui W. Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa. Pathobiology 2001 69 : 143 9.
17. Kang GH, Lee S, Lim JS, Jung HY. Profile of aberrant CpG island methylation along the multistep pathway of gastric carcinogenesis. Lab. Invest 2003 83 : 635 41.
18. Maekita T, Nakazawa K, Mihara M et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin. Cancer Res. 2006 12 : 989 95.
19. Oue N, Mitani Y, Motoshita J et al. Accumulation of DNA methylation is associated with tumor stage in gastric cancer. Cancer 2006 106 : 1250 9.
20. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis: the updated Sydney system. Am. J. Surg. Pathol. 1996 20 : 1161 81.
21. Issa JP. GpG-island methylation in aging and cancer. Curr. Top. Microbiol. Immunol. 2000 249 : 101 18.
22. Fujii S, Tominaga K, Kitajima K et al. Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis. Gut 2005 54 : 1287 92.
23. Kang GH, Lee HJ, Hwang KS, Lee S, Kim JH, Kim JS. Abberant CpG island hypermethylation of charonic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am. J. Pathol. 2003 163 : 1551 6.
24. To KF, Leung WK, Lee TL et al. Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer. Int. J. Cancer 2002 102 : 623 8.
25. Waki T, Tamura G, Tsuchiya T, Sato K, Nishizuka S, Motoyama T. Promoter methylation status of E-cadhelin, hMLH1, and p16 genes in nonneoplastic gastric epithelia. Am. J. Pathol. 2002 161 : 399 403.
26. Lauren P. The two histologic main types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand. 1965 64 : 31 49.
27. Yoshimura T, Shimoyama T, Fukuda S, Tanaka M, Axon AT, Munakata A. Most gastric cancer occurs on the distal side of the endoscopic atrophic border. Scand. J. Gastroenterol. 1999 32 : 377 82.
28. Valle J, Kekki M, Sipponen P, Ihamaki T, Siurala M. Long-term course and consequences of Helicobacter pylori gastritis. Results of a 32-year follow-up study. Scand. J. Gastroenterol. 1996 31 : 546 50.
29. Asaka M, Sugiyama T, Nobuta A, Kato M, Takeda H, Graham DY. Atrophic gastritis and intestinal metaplasia are strongly related to Helicobacter pylori infection and not to aging in Japan: results of a large multi-center study. Helicobacter 2001 6 : 294 9.
30. Nakamura A, Park A, Nagata K et al. Oxidative cellular damage associated with transformation of Helicobacter pylori from a bacillary to a coccoid form. Free Radic. Biol. Med. 2000 28 : 1611 18.
31. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic. Biol. Med. 2002 33 : 323 36.