A F240S polymorphism of protease-activated receptor 2 (PAR2) is not detected in Japanese population with gastro-esophageal symptoms

Journal of Clinical Biochemistry and Nutrition

Volumn 39, Issue 2, 2006, Pages 98-101

  Arisawa, Tomiyasu ^a   Tahara, Tomomitsu ^a   Shibata, Tomoyuki ^a   Nagasaka, Mitsuo ^a   Nakamura, Masakatsu ^a   Kamiya, Yoshio ^a   Fujita, Hiroshi ^a   Hasegawa, Shin ^a   Nakamura, Masahiko ^a   Takagi, Tamaki ^a   Hirata, Ichiro ^a   Nakano, Hiroshi ^a  

^a FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Gastric cancer; Polymorphism; Protease activated receptor 2 (PAR2)

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2;

AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HELICOBACTER PYLORI; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; STOMACH CANCER;

HELICOBACTER PYLORI;

EID: 33748925527     PISSN: 09120009     EISSN: None     Source Type: Journal    
DOI: 10.3164/jcbn.39.98     Document Type: Article

References (15)

1. Dery, O., Corvera, C.U., Steinhoff, M., and Bunnett, N.W.: Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol., 274, C1429-C1452, 1998.
2. Schmildlin, F. and Bunnett, N.W.: Protease-activated receptors: how proteases signal to cells. Curr. Opin. Pharmacol., 1(6), 575-582, 2001.
3. Molino, M., Barnathan, E.S., Numerof, R., Clark, J., Dreyer, M., Cumashi, A., Hoxie, J.A., Schechter, N., Woolkalis, M., and Brass, L.F.: Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem., 272, 4043-4049, 1997.
4. Molino, M., Woolkalis, M.J., Reavey-Cantwell, J., Pratico, D., Andrade-Gordon, P., Barnathan, E.S., and Brass, L.F.: Endothelial cell thrombin receptors and PAR-2. Two protease-activated receptors located in a single cellular environment. J. Biol. Chem., 272, 11133-11141, 1997.
5. Howells, G.L., Macey, M.G., Chinni, C., Hou, L., Fox, M.T., Harriott, P., and Stone, S.R.: Proteinase-activated receptor-2: expression by human neutrophils. J. Cell Sci., 110, 881-887, 1997.
6. Bertog, M., Letz, B., Kong, W., Steinhoff, M., Higgins, M.A., Bielfeld-Aclermann, A., Fromter, E., Bunnett, N.W., and Korbmacher, C.: Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells. J. Physiol., 521, 3-17, 1999.
7. Compton, S.J., Cairns, J.A., Palmer, K.J., Al-Ani, B., Hollenberg, M.D., and Walls, A.F.: A polymorphic protease-activated receptor 2 (PAR2) displaying reduced sensitivity to trypsin and differential responses to PAR agonists. J. Biol. Chem., 275(50), 39207-39212, 2000.
8. Hirahara, F., Miyagi, Y., Miyagi, E., Yasumitsu, H., Koshikawa, N., Nagashima, Y., Kitamura, H., Minaguchi, H., Umeda, M., and Miyazaki, K.: Trypsinogen expression in human ovarian carcinomas. Int. J. Cancer, 63, 176-181, 1995.
9. Kawano, N., Osawa, H., Ito, T., Nagashima, Y., Hirahara, F., Inayama, Y., Nakatani, Y., Kimura, S., Kitajima, H., Koshikawa, N., Miyazaki, K., and Kitamura, H.: Expression of gelatinase A, tissue inhibitor of metalloproteinases-2, matrilysin, and trypsin(ogen) in lung neoplasms: an immunohistochemical study. Hum. Pathol., 28, 613-622, 1997.
10. Miyata, S., Miyagi, Y., Koshikawa, N., Nagashima, Y., Kato, Y., Yasumitsu, H., Hirahara, F., Miyagi, K., and Miyazaki, K.: Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells. Clin. Exp. Metastasis, 16, 613-622, 1998.
11. Williams, S.J., Gotley, D.C., and Antalis, T.M.: Human trypsinogen in colorectal cancer. Int. J. Cancer, 93, 67-73, 2001.
12. Lukkonen, A., Sorsa, T., Salo, T., Tervahartiala, T., Koivunen, E., Golub, L., Simon, S., and Stenman, U.H.: Down-regulation of trypsinogen-2 expression by chemically modified tetracyclines: association with reduced cancer cell migration. Int. J. Cancer, 86, 577-581, 2000.
13. Kennedy, A.R., Billings, P.C., Wan, X.S., and Newberne, P.M.: Effects of Bowman-Birk inhibitor on rat colon carcinogenesis. Nutr. Cancer, 43, 174-186, 2001.
14. Yamashita, K., Mimori, K., Inoue, H., Mori, M., and Sidransky, D.: A tumor-supressive role for trypsin in human cancer progression. Cancer Res., 63, 6575-6578, 2003.
15. Jemal, A., Tiwari, R.C., Murray, T., Ghafoor, A., Samuels, A., Ward, E., Feuer, E.J., and Thun, M.J.: American Cancer Society: Cancer statistics, 2004. C.A. Cancer J. Clin., 54, 8-29, 2004.