Promoter methylation status of the DNA repair genes hMLH1 and MGMT in gastric carcinoma and metaplastic mucosa

Pathobiology

Volumn 69, Issue 3, 2001, Pages 143-149

  Oue, Naohide ^a   Sentani, Kazuhiro ^a   Yokozaki, Hiroshi ^a   Kitadai, Yasuhiko ^a   Ito, Reiko ^a   Yasui, Wataru ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

DNA methylation; Gastric carcinoma; hMLH1; Intestinal metaplastic mucosa; MGMT

Indexed keywords

METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN; PROTEIN MLH1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPAIR; DNA SEQUENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MAJOR CLINICAL STUDY; METHYLATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEQUENCE ANALYSIS; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CARRIER PROTEINS; DNA METHYLATION; DNA REPAIR; DNA, NEOPLASM; GASTRIC MUCOSA; HUMANS; IMMUNOENZYME TECHNIQUES; NEOPLASM PROTEINS; NUCLEAR PROTEINS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POLYMERASE CHAIN REACTION; PRECANCEROUS CONDITIONS; PROMOTER REGIONS (GENETICS); STOMACH NEOPLASMS;

MARTES PENNANTI;

EID: 0035724734     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048769     Document Type: Article

References (32)

1. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
2. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
3. Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability
4. Methylation of CpG island transcription factor binding sites is unnecessary for aberrant silencing of the human MGMT gene
5. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
6. A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers
7. Promoter hypermethylation of MGMT is associated with protein loss in gastric carcinoma
8. Epigenetic phenotypes distinguish microsatellite-stable and -unstable colorectal cancers
9. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
10. Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype
11. The two histological main types of gastric carcinoma. Diffuse and so-called intestinal type carcinoma: An attempt at histological classification
12. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
13. DNA methylation status of hMLH1, p16INK4a, and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas
14. Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas
15. Expression of transforming growth factor alpha in human tissues: Immunohistochemical study and Northern blot analysis
16. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
17. Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype
18. CpG island methylator phenotype in colorectal cancer
19. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
20. Genetic and epigenetic changes in stomach cancer
21. Loss of DNA mismatch repair in acquired resistance to cisplatin
22. Loss of DNA mismatch repair: Effects on the rate of mutation to drug resistance
23. Enrichment for DNA mismatch repair-deficient cells during treatment with cis-platin
24. Analysis of MLH1 and MSH2 expression in ovarian cancer before and after platinum drug-based chemotherapy
25. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
26. Separation of killing and tumori-genic effects of an alkylating agent in mice defective in two of the DNA repair genes
27. Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage
28. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
29. Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer
30. Altered microsatellites in incomplete-type intestinal metaplasia adjacent to primary gastric cancers
31. Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1
32. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer