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Volumn 48, Issue 1, 2007, Pages 16-24

Bcl-2 expression and apoptosis in the regulation of hematopoietic stem cells

Author keywords

[No Author keywords available]

Indexed keywords

BH3 PROTEIN; CASPASE; CYTOKINE; FAS ANTIGEN; FLT3 LIGAND; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; STEM CELL FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

EID: 34247235661     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190601032529     Document Type: Review
Times cited : (17)

References (74)
  • 1
    • 0026493579 scopus 로고
    • The haemopoietic stem cell and its clonal progeny: Mechanisms regulating the hierarchy of primitive haematopoietic cells
    • Lemischka, I. R. (1992) The haemopoietic stem cell and its clonal progeny: Mechanisms regulating the hierarchy of primitive haematopoietic cells. Cancer Surveys, 15, pp. 3-18.
    • (1992) Cancer Surveys , vol.15 , pp. 3-18
    • Lemischka, I.R.1
  • 2
    • 0032078573 scopus 로고    scopus 로고
    • Development of the definitive hematopoietic hierarchy in the mouse
    • Medvinsky, A. L. and Dzierzak, E. A. (1998) Development of the definitive hematopoietic hierarchy in the mouse. Dev Comp Immunol, 22, pp. 289-301.
    • (1998) Dev Comp Immunol , vol.22 , pp. 289-301
    • Medvinsky, A.L.1    Dzierzak, E.A.2
  • 3
    • 0034303586 scopus 로고    scopus 로고
    • Diversification of haematopoietic stem cells to specific lineages
    • Orkin, S. (2000) Diversification of haematopoietic stem cells to specific lineages. Nature Rev, 1, pp. 57-64.
    • (2000) Nature Rev , vol.1 , pp. 57-64
    • Orkin, S.1
  • 4
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M. J., Yilmaz, O. H., Iwashita, T., Yilmaz, O. H., Terhorst, C. and Morrison, S. J. (2005) SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121, pp. 1109-1121.
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1    Yilmaz, O.H.2    Iwashita, T.3    Yilmaz, O.H.4    Terhorst, C.5    Morrison, S.J.6
  • 5
    • 0026500983 scopus 로고
    • Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
    • Ikuta, K. and Weissman, I. L. (1992) Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation. Proc Natl Acad Sci USA, 89, pp. 1502-1506.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1502-1506
    • Ikuta, K.1    Weissman, I.L.2
  • 6
    • 0030483541 scopus 로고    scopus 로고
    • Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo
    • Sanchez, M. J., Holmes, A., Miles, C. and Dzierzak, E. (1996) Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo. Immunity, 5, pp. 513-525.
    • (1996) Immunity , vol.5 , pp. 513-525
    • Sanchez, M.J.1    Holmes, A.2    Miles, C.3    Dzierzak, E.4
  • 7
    • 0036458657 scopus 로고    scopus 로고
    • The Ly-6A (Sca-1) GFP transgene is expressed in all adult mouse hematopoietic stem cells
    • Robin, C., Ottersbach, K. and Dzierzak, E. (2002) The Ly-6A (Sca-1) GFP transgene is expressed in all adult mouse hematopoietic stem cells. Stem Cells, 20, pp. 514-521.
    • (2002) Stem Cells , vol.20 , pp. 514-521
    • Robin, C.1    Ottersbach, K.2    Dzierzak, E.3
  • 8
    • 0031779076 scopus 로고    scopus 로고
    • Qualitative and quantitative aspects of hematopoietic cell development in the mammalian embryo
    • Dzierzak, E., Medvinsky, A. and de Bruijn, M. (1998) Qualitative and quantitative aspects of hematopoietic cell development in the mammalian embryo. Imm Today, 19, pp. 228-236.
    • (1998) Imm Today , vol.19 , pp. 228-236
    • Dzierzak, E.1    Medvinsky, A.2    de Bruijn, M.3
  • 9
    • 0038021272 scopus 로고    scopus 로고
    • Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more
    • Marsden, V. S. and Strasser, A. (2003) Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol, 21, pp. 71-105.
    • (2003) Annu Rev Immunol , vol.21 , pp. 71-105
    • Marsden, V.S.1    Strasser, A.2
  • 10
    • 0032980506 scopus 로고    scopus 로고
    • In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
    • Cheshier, S. H., Morrison, S. J., Liao, X. and Weissman, I. L. (1999) In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells. Proc Natl Acad Sci USA, 96, pp. 3120-3125.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3120-3125
    • Cheshier, S.H.1    Morrison, S.J.2    Liao, X.3    Weissman, I.L.4
  • 11
    • 0031028973 scopus 로고    scopus 로고
    • Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity
    • de Haan, G., Nijhof, W. and van Zant, G. (1997) Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity. Blood, 89, pp. 1543-1550.
    • (1997) Blood , vol.89 , pp. 1543-1550
    • de Haan, G.1    Nijhof, W.2    van Zant, G.3
  • 12
    • 0037105365 scopus 로고    scopus 로고
    • A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
    • de Haan, G., Bystrykh, L. V., Weersing, E., Dontje, B., Geiger, H. and Ivanova, N. (2002) A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover. Blood, 100, pp. 2056-2062.
    • (2002) Blood , vol.100 , pp. 2056-2062
    • de Haan, G.1    Bystrykh, L.V.2    Weersing, E.3    Dontje, B.4    Geiger, H.5    Ivanova, N.6
  • 13
    • 0033562357 scopus 로고    scopus 로고
    • Dynamic changes in mouse hematopoietic stem cell numbers during aging
    • de Haan, G. and van Zant, G. (1999) Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood, 93, pp. 3294-3301.
    • (1999) Blood , vol.93 , pp. 3294-3301
    • de Haan, G.1    van Zant, G.2
  • 14
    • 0030248792 scopus 로고    scopus 로고
    • Telomerase activity in hematopoietic cells is associated with self-renewal potential
    • Morrison, S. J., Prowse, K. R. and Weismann, I. L. (1996) Telomerase activity in hematopoietic cells is associated with self-renewal potential. Immunity, 5, pp. 207-216.
    • (1996) Immunity , vol.5 , pp. 207-216
    • Morrison, S.J.1    Prowse, K.R.2    Weismann, I.L.3
  • 15
    • 0037089438 scopus 로고    scopus 로고
    • Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells
    • Samper, E., Fernandez, P., Eguia, R., Martin-Rivera, L., Bernad, A. and Blasco, M. A. (2002) Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood, 99, pp. 2767-2775.
    • (2002) Blood , vol.99 , pp. 2767-2775
    • Samper, E.1    Fernandez, P.2    Eguia, R.3    Martin-Rivera, L.4    Bernad, A.5    Blasco, M.A.6
  • 16
    • 0028467947 scopus 로고
    • Development of hematopoietic stem cell activity in the mouse embryo
    • Muller, A. M., Medvinsky, A., Strouboulis, J., Grosveld, F. and Dzierzak, E. (1994) Development of hematopoietic stem cell activity in the mouse embryo. Immunity, 1, pp. 291-301.
    • (1994) Immunity , vol.1 , pp. 291-301
    • Muller, A.M.1    Medvinsky, A.2    Strouboulis, J.3    Grosveld, F.4    Dzierzak, E.5
  • 17
    • 0030595341 scopus 로고    scopus 로고
    • Definitive hematopoiesis is autonomously initiated by the AGM region
    • Medvinsky, A. and Dzierzak, E. (1996) Definitive hematopoiesis is autonomously initiated by the AGM region. Cell, 86, pp. 897-906.
    • (1996) Cell , vol.86 , pp. 897-906
    • Medvinsky, A.1    Dzierzak, E.2
  • 18
    • 0034214284 scopus 로고    scopus 로고
    • Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo
    • de Bruijn, M. F., Speck, N. A., Peeters, M. C. and Dzierzak, E. (2000) Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo. EMBO J, 19, pp. 2465-2474.
    • (2000) EMBO J , vol.19 , pp. 2465-2474
    • de Bruijn, M.F.1    Speck, N.A.2    Peeters, M.C.3    Dzierzak, E.4
  • 20
    • 16844372863 scopus 로고    scopus 로고
    • Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny
    • Mendes, S. C., Robin, C. and Dzierzak, E. (2005) Mesenchymal progenitor cells localize within hematopoietic sites throughout ontogeny. Development, 132, pp. 1127-1136.
    • (2005) Development , vol.132 , pp. 1127-1136
    • Mendes, S.C.1    Robin, C.2    Dzierzak, E.3
  • 21
    • 14644437071 scopus 로고    scopus 로고
    • The murine placenta contains hematopoietic stem cells within the vascular labyrinth region
    • Ottersbach, K. and Dzierzak, E. (2005) The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. Dev Cell, 8, pp. 377-387.
    • (2005) Dev Cell , vol.8 , pp. 377-387
    • Ottersbach, K.1    Dzierzak, E.2
  • 22
    • 14644416569 scopus 로고    scopus 로고
    • The placenta is a niche for hematopoietic stem cells
    • Gekas, C., Dieterlen-Lievre, F., Orkin, S. H. and Mikkola, H. K. (2005) The placenta is a niche for hematopoietic stem cells. Dev Cell, 8, pp. 365-375.
    • (2005) Dev Cell , vol.8 , pp. 365-375
    • Gekas, C.1    Dieterlen-Lievre, F.2    Orkin, S.H.3    Mikkola, H.K.4
  • 23
    • 0036848557 scopus 로고    scopus 로고
    • Quantitative developmental anatomy of definitive hematopoietic stem cells/long-term repopulating units (HSC/RUs): Role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver
    • Kumaravelu, P., Hook, L., Morrison, A. M., Ure, J., Zhao, S. and Zuyev, S. (2002) Quantitative developmental anatomy of definitive hematopoietic stem cells/long-term repopulating units (HSC/RUs): Role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver. Development, 129, pp. 4891-4899.
    • (2002) Development , vol.129 , pp. 4891-4899
    • Kumaravelu, P.1    Hook, L.2    Morrison, A.M.3    Ure, J.4    Zhao, S.5    Zuyev, S.6
  • 24
    • 0034177619 scopus 로고    scopus 로고
    • Expansion of hematopoietic stem cells in the developing liver of a mouse embryo
    • Ema, H. and Nakauchi, H. (2000) Expansion of hematopoietic stem cells in the developing liver of a mouse embryo. Blood, 95, pp. 2284-2288.
    • (2000) Blood , vol.95 , pp. 2284-2288
    • Ema, H.1    Nakauchi, H.2
  • 25
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore, K. A. and Lemischka, I. R. (2006) Stem cells and their niches. Science, 311, pp. 1880-1885.
    • (2006) Science , vol.311 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 26
    • 33644855216 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
    • Maurer, U., Charvet, C., Wagman, A. S., Dejardin, E. and Green, D. R. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell, 21, pp. 749-760.
    • (2006) Mol Cell , vol.21 , pp. 749-760
    • Maurer, U.1    Charvet, C.2    Wagman, A.S.3    Dejardin, E.4    Green, D.R.5
  • 27
    • 0346100667 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes
    • Karlsson, R., Engstrom, M., Jonsson, M., Karlberg, P., Pronk, C. J. and Richter, J. (2003) Phosphatidylinositol 3-kinase is essential for kit ligand-mediated survival, whereas interleukin-3 and flt3 ligand induce expression of antiapoptotic Bcl-2 family genes. J Leukoc Biol, 74, pp. 923-931.
    • (2003) J Leukoc Biol , vol.74 , pp. 923-931
    • Karlsson, R.1    Engstrom, M.2    Jonsson, M.3    Karlberg, P.4    Pronk, C.J.5    Richter, J.6
  • 28
    • 0034194365 scopus 로고    scopus 로고
    • Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells
    • Sanz, C., Benito, A., Inohara, N., Ekhterae, D., Nunez, G. and Fernandez-Luna, J. L. (2000) Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells. Blood, 95, pp. 2742-2747.
    • (2000) Blood , vol.95 , pp. 2742-2747
    • Sanz, C.1    Benito, A.2    Inohara, N.3    Ekhterae, D.4    Nunez, G.5    Fernandez-Luna, J.L.6
  • 29
    • 0035135349 scopus 로고    scopus 로고
    • Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors
    • Shinjyo, T., Kuribara, R., Inukai, T., Hosoi, H., Kinoshita, T. and Miyajima, A. (2001) Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors. Mol Cell Biol, 21, pp. 854-864.
    • (2001) Mol Cell Biol , vol.21 , pp. 854-864
    • Shinjyo, T.1    Kuribara, R.2    Inukai, T.3    Hosoi, H.4    Kinoshita, T.5    Miyajima, A.6
  • 31
    • 0242363225 scopus 로고    scopus 로고
    • Identification of the haematopoietic stem cell niche and control of the niche size
    • Zhang, J., Niu, C., Huang, H. and Tong, W. G. (2003) Identification of the haematopoietic stem cell niche and control of the niche size. Nature, 425, pp. 836-841.
    • (2003) Nature , vol.425 , pp. 836-841
    • Zhang, J.1    Niu, C.2    Huang, H.3    Tong, W.G.4
  • 32
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai, F., Hirao, A., Ohmura, M., Sato, H., Matsuoka, S. and Takubo, K. (2004) Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell, 118, pp. 149-161.
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1    Hirao, A.2    Ohmura, M.3    Sato, H.4    Matsuoka, S.5    Takubo, K.6
  • 33
    • 0037092512 scopus 로고    scopus 로고
    • Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis
    • Oostendorp, R. A., Medvinsky, A. J., Kusadasi, N., Nakayama, N., Harvey, K. and Orelio, C. (2002) Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis. J Cell Sci, 115, pp. 2099-2108.
    • (2002) J Cell Sci , vol.115 , pp. 2099-2108
    • Oostendorp, R.A.1    Medvinsky, A.J.2    Kusadasi, N.3    Nakayama, N.4    Harvey, K.5    Orelio, C.6
  • 34
    • 20344370721 scopus 로고    scopus 로고
    • Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures
    • Oostendorp, R. A., Robin, C., Steinhoff, C., Marz, S., Brauer, R. and Nuber, U. A. (2005) Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures. Stem Cells, 23, pp. 842-851.
    • (2005) Stem Cells , vol.23 , pp. 842-851
    • Oostendorp, R.A.1    Robin, C.2    Steinhoff, C.3    Marz, S.4    Brauer, R.5    Nuber, U.A.6
  • 35
    • 0029930165 scopus 로고    scopus 로고
    • Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain long-term repopulating stem cells
    • Wineman, J., Moore, K., Lemischka, I. and Muller-Sieburg, C. (1996) Functional heterogeneity of the hematopoietic microenvironment: Rare stromal elements maintain long-term repopulating stem cells. Blood, 87, pp. 4082-4090.
    • (1996) Blood , vol.87 , pp. 4082-4090
    • Wineman, J.1    Moore, K.2    Lemischka, I.3    Muller-Sieburg, C.4
  • 36
    • 33746520121 scopus 로고    scopus 로고
    • An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells
    • Robin, C., Ottersbach, K., Durand, C., Peeters, M., Vanes, L. and Tybulewicz, V. (2006) An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells. Dev Cell, 11, pp. 171-180.
    • (2006) Dev Cell , vol.11 , pp. 171-180
    • Robin, C.1    Ottersbach, K.2    Durand, C.3    Peeters, M.4    Vanes, L.5    Tybulewicz, V.6
  • 37
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha, J., Harada, H., Yang, E., Jockel, J. and Korsmeyer, S. J. (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell, 87, pp. 619-628.
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 38
    • 0033534594 scopus 로고    scopus 로고
    • Interleukin-3 induces the phosphorylation of a distinct fraction of bcl-2
    • Poommipanit, P. B., Chen, B. and Oltvai, Z. N. (1999) Interleukin-3 induces the phosphorylation of a distinct fraction of bcl-2. J Biol Chem, 274, pp. 1033-1039.
    • (1999) J Biol Chem , vol.274 , pp. 1033-1039
    • Poommipanit, P.B.1    Chen, B.2    Oltvai, Z.N.3
  • 39
    • 0030959304 scopus 로고    scopus 로고
    • Bcl-2 phosphorylation required for anti-apoptosis function
    • Ito, T., Deng, X., Carr, B. and May, W. S. (1997) Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem, 272, pp. 11671-11673.
    • (1997) J Biol Chem , vol.272 , pp. 11671-11673
    • Ito, T.1    Deng, X.2    Carr, B.3    May, W.S.4
  • 40
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M. O. (2000) The biochemistry of apoptosis. Nature, 407, pp. 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 41
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen, G. M. (1997) Caspases: The executioners of apoptosis. Biochem J, 326, pp. 1-16.
    • (1997) Biochem J , vol.326 , pp. 1-16
    • Cohen, G.M.1
  • 42
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: Signaling and modulation
    • Ashkenazi, A. and Dixit, V. M. (1998) Death receptors: Signaling and modulation. Science, 281, pp. 1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 43
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry, N. A. and Lazebnik, Y. (1998) Caspases: Enemies within. Science, 281, pp. 1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 44
    • 33645299092 scopus 로고    scopus 로고
    • Caspases at the crossroads of immune-cell life and death
    • Siegel, R. M. (2006) Caspases at the crossroads of immune-cell life and death. Nat Rev Immunol, 6, pp. 308-317.
    • (2006) Nat Rev Immunol , vol.6 , pp. 308-317
    • Siegel, R.M.1
  • 45
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Tsujimoto, Y., Gorham, J., Cossman, J., Jaffe, E. and Croce, C. M. (1985) The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science, 229, pp. 1390-1393.
    • (1985) Science , vol.229 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3    Jaffe, E.4    Croce, C.M.5
  • 46
    • 0022971142 scopus 로고
    • Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/ immunoglobulin transcript resulting from the t(14;18) translocation
    • Cleary, M. L., Smith, S. D. and Sklar, J. (1986) Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell, 47, pp. 19-28.
    • (1986) Cell , vol.47 , pp. 19-28
    • Cleary, M.L.1    Smith, S.D.2    Sklar, J.3
  • 47
    • 0023786047 scopus 로고
    • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
    • Vaux, D. L., Cory, S. and Adams, J. M. (1988) Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature, 335, pp. 440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, J.M.3
  • 48
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J. (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature, 348, pp. 334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenbery, D.1    Nunez, G.2    Milliman, C.3    Schreiber, R.D.4    Korsmeyer, S.J.5
  • 49
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
    • McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U. and McKearn, J. P. (1989) Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell, 57, pp. 79-88.
    • (1989) Cell , vol.57 , pp. 79-88
    • McDonnell, T.J.1    Deane, N.2    Platt, F.M.3    Nunez, G.4    Jaeger, U.5    McKearn, J.P.6
  • 50
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams, J. M. and Cory, S. (1998) The Bcl-2 protein family: Arbiters of cell survival. Science, 281, pp. 1322-1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 51
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross, A., McDonnell, J. M. and Korsmeyer, S. J. (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev, 13, pp. 1899-1911.
    • (1999) Genes Dev , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 52
    • 0033450756 scopus 로고    scopus 로고
    • A portrait of the Bcl-2 protein family: Life, death, and the whole picture
    • Pellegrini, M. and Strasser, A. (1999) A portrait of the Bcl-2 protein family: Life, death, and the whole picture. J Clin Immunol, 19, pp. 365-377.
    • (1999) J Clin Immunol , vol.19 , pp. 365-377
    • Pellegrini, M.1    Strasser, A.2
  • 53
    • 0034523818 scopus 로고    scopus 로고
    • Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
    • Korsmeyer, S. J., Wei, M. C., Saito, M., Weiler, S., Oh, K. J. and Schlesinger, P. H. (2000) Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ, 7, pp. 1166-1173.
    • (2000) Cell Death Differ , vol.7 , pp. 1166-1173
    • Korsmeyer, S.J.1    Wei, M.C.2    Saito, M.3    Weiler, S.4    Oh, K.J.5    Schlesinger, P.H.6
  • 54
    • 0025835716 scopus 로고
    • Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death
    • Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. and Korsmeyer, S. J. (1991) Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc Natl Acad Sci USA, 88, pp. 6961-6965.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6961-6965
    • Hockenbery, D.M.1    Zutter, M.2    Hickey, W.3    Nahm, M.4    Korsmeyer, S.J.5
  • 55
    • 0027958313 scopus 로고
    • Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages
    • Lagasse, E. and Weissman, I. L. (1994) Bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J Exp Med, 179, pp. 1047-1052.
    • (1994) J Exp Med , vol.179 , pp. 1047-1052
    • Lagasse, E.1    Weissman, I.L.2
  • 56
    • 0028362899 scopus 로고
    • Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes
    • Park, J. R., Robertson, K., Hickstein, D. D., Tsai, S., Hockenbery, D. M. and Collins, S. J. (1994) Dysregulated bcl-2 expression inhibits apoptosis but not differentiation of retinoic acid-induced HL-60 granulocytes. Blood, 84, pp. 440-445.
    • (1994) Blood , vol.84 , pp. 440-445
    • Park, J.R.1    Robertson, K.2    Hickstein, D.D.3    Tsai, S.4    Hockenbery, D.M.5    Collins, S.J.6
  • 57
    • 0025786164 scopus 로고
    • Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    • Strasser, A., Harris, A. W. and Cory, S. (1991) Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell, 67, pp. 889-899.
    • (1991) Cell , vol.67 , pp. 889-899
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 58
    • 0025939204 scopus 로고
    • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
    • Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M. and Cory, S. (1991) Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA, 88, pp. 8661-8665.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 8661-8665
    • Strasser, A.1    Whittingham, S.2    Vaux, D.L.3    Bath, M.L.4    Adams, J.M.5    Cory, S.6
  • 60
    • 0029156492 scopus 로고
    • Primitive human hematopoietic precursors express Bcl-x but not Bcl-2
    • Park, J. R., Bernstein, I. D. and Hockenbery, D. M. (1995) Primitive human hematopoietic precursors express Bcl-x but not Bcl-2. Blood, 86, pp. 868-876.
    • (1995) Blood , vol.86 , pp. 868-876
    • Park, J.R.1    Bernstein, I.D.2    Hockenbery, D.M.3
  • 61
    • 0032530301 scopus 로고    scopus 로고
    • Apoptotic regulation in primitive hematopoietic precursors
    • Peters, R., Leyvraz, S. and Perey, L. (1998) Apoptotic regulation in primitive hematopoietic precursors. Blood, 92, pp. 2041-2052.
    • (1998) Blood , vol.92 , pp. 2041-2052
    • Peters, R.1    Leyvraz, S.2    Perey, L.3
  • 62
    • 0028175759 scopus 로고
    • Targeted disruption of Bcl-2 alpha beta in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
    • Nakayama, K., Nakayama, K., Negishi, I., Kuida, K., Sawa, H. and Loh, D. Y. (1994) Targeted disruption of Bcl-2 alpha beta in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA, 91, pp. 3700-3704.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3700-3704
    • Nakayama, K.1    Nakayama, K.2    Negishi, I.3    Kuida, K.4    Sawa, H.5    Loh, D.Y.6
  • 63
    • 0027427492 scopus 로고
    • Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • Veis, D. J., Sorenson, C. M., Shutter, J. R. and Korsmeyer, S. J. (1993) Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell, 75, pp. 229-240.
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 64
    • 0028922885 scopus 로고
    • Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
    • Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K. and Nakayama, K. (1995) Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science, 267, pp. 1506-1510.
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.5    Nakayama, K.6
  • 65
    • 0031962758 scopus 로고    scopus 로고
    • Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment
    • Ogilvy, S., Elefanty, A. G., Visvader, J., Bath, M. L., Harris, A. W. and Adams, J. M. (1998) Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment. Blood, 91, pp. 419-430.
    • (1998) Blood , vol.91 , pp. 419-430
    • Ogilvy, S.1    Elefanty, A.G.2    Visvader, J.3    Bath, M.L.4    Harris, A.W.5    Adams, J.M.6
  • 66
    • 0033593038 scopus 로고    scopus 로고
    • Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival
    • Ogilvy, S., Metcalf, D., Print, C. G., Bath, M. L., Harris, A. W. and Adams, J. M. (1999) Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA, 96, pp. 14943-14948.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14943-14948
    • Ogilvy, S.1    Metcalf, D.2    Print, C.G.3    Bath, M.L.4    Harris, A.W.5    Adams, J.M.6
  • 67
    • 0032055166 scopus 로고    scopus 로고
    • Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation
    • Domen, J., Gandy, K. L. and Weissman, I. L. (1998) Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood, 91, pp. 2272-2282.
    • (1998) Blood , vol.91 , pp. 2272-2282
    • Domen, J.1    Gandy, K.L.2    Weissman, I.L.3
  • 68
    • 0034684662 scopus 로고    scopus 로고
    • Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other
    • Domen, J. and Weissman, I. L. (2000) Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. J Exp Med, 192, pp. 1707-1718.
    • (2000) J Exp Med , vol.192 , pp. 1707-1718
    • Domen, J.1    Weissman, I.L.2
  • 69
    • 0034677173 scopus 로고    scopus 로고
    • The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential
    • Domen, J., Cheshier, S. H. and Weissman, I. L. (2000) The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potential. J Exp Med, 191, pp. 253-264.
    • (2000) J Exp Med , vol.191 , pp. 253-264
    • Domen, J.1    Cheshier, S.H.2    Weissman, I.L.3
  • 70
    • 2542418036 scopus 로고    scopus 로고
    • The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression
    • Orelio, C., Harvey, K. N., Miles, C., Oostendorp, R. A., van der Horn, K. and Dzierzak, E. (2004) The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression. Blood, 103, pp. 4084-4092.
    • (2004) Blood , vol.103 , pp. 4084-4092
    • Orelio, C.1    Harvey, K.N.2    Miles, C.3    Oostendorp, R.A.4    van der Horn, K.5    Dzierzak, E.6
  • 71
    • 0036285647 scopus 로고    scopus 로고
    • Hematopoietic stem cells localize to the endothelial cell layer in the mid-gestation mouse aorta
    • de Bruijn, M. F., Robin, C., Ottersbach, K., Sanchez, M. J. and Dzierzak, E. (2002) Hematopoietic stem cells localize to the endothelial cell layer in the mid-gestation mouse aorta. Immunity, 16, pp. 673-683.
    • (2002) Immunity , vol.16 , pp. 673-683
    • de Bruijn, M.F.1    Robin, C.2    Ottersbach, K.3    Sanchez, M.J.4    Dzierzak, E.5
  • 74
    • 0037737728 scopus 로고    scopus 로고
    • A role for Wnt signalling in self-renewal of haematopoietic stem cells
    • Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C. and Willert, K. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423, pp. 409-414.
    • (2003) Nature , vol.423 , pp. 409-414
    • Reya, T.1    Duncan, A.W.2    Ailles, L.3    Domen, J.4    Scherer, D.C.5    Willert, K.6


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