Mitochondrial permeability transition and swelling can occur reversibly without inducing cell death in intact human cells

Experimental Cell Research

Volumn 246, Issue 1, 1999, Pages 26-37

  Minamikawa, Tetsuhiro ^a   Williams, David A ^b   Bowser, David N ^b   Nagley, Phillip ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Confocal microscopy; Fluorescence; Mitochondrial membrane potential; Mitochondrial permeability transition; Mitochondrial swelling

Indexed keywords

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; OSTEOSARCOMA; PRIORITY JOURNAL;

MAMMALIA;

EID: 0033540289     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1998.4290     Document Type: Article

References (35)

1. Petit P. X., Lecoeur H., Zorn E., Dauguet C., Mignotte B., Gougeon M.-L. Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis. J. Cell Biol. 130:1995;157-167.
2. Yang J., Liu X., Bhalla K., Kim C. N., Ibrado A. M., Cai J., Peng T. I., Jones D. P., Wang X. Prevention of apoptosis by Bcl-2: Release of cytochromec. Science. 275:1997;1129-1132.
3. Scarlett J. L., Murphy M. P. Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition. FEBS Lett. 418:1997;282-286.
4. Kluck R. M., Bossy-Wetzel E., Green D. R., Newmeyer D. D. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 275:1997;1132-1136.
5. Mignotte B., Vayssiere J.-L. Mitochondria and apoptosis. Eur. J. Biochem. 252:1998;1-15.
6. Petronilli V., Nicolli A., Costantini P., Colonna R., Bernardi P. Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A. Biochim. Biophys. Acta. 1187:1994;255-259.
7. Ichas F., Jouaville L. S., Mazat J.-P. Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell. 89:1997;1145-1153.
8. Hueser J., Rechenmacher C. E., Blatter L. A. Imaging the permeability pore transition in single mitochondria. Biophys. J. 74:1998;2129-2137.
9. Cassarino D. S., Swerdlow R. H., Parks J. K., Parker J. W. D., Bennett J. J. P. Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids. Biochem. Biophys. Res. Commun. 248:1998;168-173.
10. Petronilli V., Bernardi P., Canton M., Colonna R., Miotto G., Di Lisa F. Direct evidence of the mitochondrial permeability transition pore in single living cells. Biophys. J. 74:1998;A383.
11. Wallach D. F. H., Steck T. L. Fluorescence techniques in the microdetermination of metals in biological materials. Anal. Chem. 35:1963;1035-1044.
12. Llopis J., McCaffery J. M., Miyawaki A., Farquhar M. G., Tsien R. Y. Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc. Natl. Acad. Sci. USA. 95:1998;6803-6808.
13. Salet C., Moreno G., Ricchelli F., Bernardi P. Singlet oxygen produced by photodynamic action causes inactivation of the mitochondrial permeability transition pore. J. Biol. Chem. 272:1997;21938-21943.
14. Kaye A. H., Morstyn G., Ashcroft R. G. Uptake and retention of haematoporphyrin derivative in an in vivo/in vitro model of cerebral glioma. Neurosurgery. 17:1985;883-890.
15. Reers M., Smiley S. T., Mottola-Hartshorn C., Chen A., Lin M., Chen L. B. Mitochondrial membrane potential monitored by JC-1 dye. Methods Enzymol. 260:1995;406-417.
16. Ankarcrona M., Dypbukt J. M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S. A., Nicotera P. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
17. Camilleri-Broet S., Vanderwerff H., Caldwell E., Hockenbery D. Distinct alterations in mitochondrial mass and function characterize different models of apoptosis. Exp. Cell Res. 239:1998;277-292.
18. Troyan M. B., Gilman V. R., Gay C. V. Mitochondrial membrane potential changes in osteoblasts treated with parathyroid hormone and estradiol. Exp. Cell Res. 233:1997;274-280.
19. Poot M., Zhang Y.-Z., Kraemer J. A., Wells K. S., Jones L. J., Hanzel D. K., Lugade A. G., Singer V. L., Haugland R. P. Analysis of mitochondrial morphology and function with novel fixable fluorescent stains. J. Histochem. Cytochem. 44:1996;1363-1372.
20. Macho A., Decaudin D., Castedo M., Hirsch T., Susin S. A., Zamzami N., Kroemer G. Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis. Cytometry. 25:1996;333-340.
21. Nieminen A.-L., Saylor A. K., Tesfai S. A., Herman B., Lemasters J. J. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes tot. Biochem. J. 307:1995;99-106.
22. Zoratti M., Szabo I. The mitochondrial permeability transition. Biochim. Biophys. Acta. 1241:1995;139-176.
23. Zamzami N., Marchetti P., Castedo M., Hirsch T., Susin S. A., Masse B., Kroemer G. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 384:1996;53-57.
24. Bossy-Wetzel E., Newmeyer D. D., Green D. R. Mitochondrial cytochromec. EMBO J. 17:1998;37-49.
25. Pastorino J. G., Chen S.-T., Tafani M., Snyder J. W., Farber J. L. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition. J. Biol. Chem. 273:1998;7770-7775.
26. Scorrano L., Petronilli V., Bernardi P. On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal. J. Biol. Chem. 272:1997;12295-12299.
27. 2+. J. Biol. Chem. 268:1993;1005-1010.
28. Bowser D. N., Minamikawa T., Nagley P., Williams D. A. Role of mitochondria in calcium regulation of spontaneously contracting cardiac muscle cells. Biophys. J. 75:1998;2004-2014.
29. Petit P. X., Susin S.-A., Zamzami N., Mignotte B., Kroemer G. Mitochondria and programmed cell death: Back to the future. FEBS Lett. 396:1996;7-13.
30. Hoek J. B., Farber J. L., Thomas A. P., Wang X. Calcium ion-dependent signalling and mitochondrial dysfunction: Mitochondrial calcium uptake during hormonal stimulation in intact liver cells and its implication for the mitochondrial permeability transition. Biochim. Biophys. Acta. 1271:1995;93-102.
31. Gunter T. E., Pfeiffer D. R. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258:1990;C755-C786.
32. Reipert S., Berry J., Hughes M. F., Hickman J. A., Allen T. D. Changes of mitochondrial mass in the hemopoietic stem cell line FDCP-mix after treatment with etoposide: A correlative study by multiparameter flow cytometry and confocal and electron microscopy. Exp. Cell Res. 221:1995;281-288.
33. Mancini M., Anderson B. O., Caldwell E., Sedghinasab M., Paty P. B., Hockenbery D. M. Mitochondrial proliferation and paradoxical membrane depolarization during terminal differentiation and apoptosis in a human colon carcinoma cell line. J. Cell Biol. 138:1997;449-469.
34. Trost L. C., Lemasters J. J. Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: Implications for the pathogenesis of Reye's syndrome. Toxicol. Appl. Pharmacol. 147:1997;431-441.
35. Petit P. X., Gourbern M., Diolez P., Susin S. A., Zamzami N., Kroemer G. Disruption of the outer mitochondrial membrane as a result of large amplitude swelling: The impact of irreversible permeability transition. FEBS Lett. 426:1998;111-116.