Vitamin E attenuates biochemical and morphological features associated with development of chronic pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 287, Issue 1 50-1, 2004, Pages

  Gómez, José Antonio ^a   Molero, Xavier ^a   Vaquero, Eva ^a   Alonso, Ana ^a   Salas, Antonio ^b   Malagelada, Juan R ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b HOSPITAL MÚTUA DE TERRASSA   (Spain)

Author keywords

Caerulein; Cyclosporin; Fibrogenesis; Myofibroblasts

Indexed keywords

8 ISOPROSTANE; ALPHA TOCOPHEROL; ANTIOXIDANT; CERULETIDE; COLLAGEN; CYCLOSPORIN A; HYALURONIC ACID; HYDROXYPROLINE; ISOPROSTANE DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL COUNT; CELL PROLIFERATION; CHRONIC PANCREATITIS; CONNECTIVE TISSUE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; MALE; MICROSCOPY; MYOFIBROBLAST; NONHUMAN; ORGAN WEIGHT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; SCORING SYSTEM; TISSUE HOMOGENATE;

ANIMALS; CAERULEIN; CHRONIC DISEASE; COLLAGEN; CYCLOSPORINE; FIBROBLASTS; FIBROSIS; LIPID PEROXIDATION; LIPOPROTEINS; MALE; MYOCYTES, SMOOTH MUSCLE; PANCREAS; PANCREATITIS; RATS; RATS, WISTAR; VITAMIN E;

EID: 3042552573     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00333.2003     Document Type: Article

References (60)

1. Abdu KM, Rao G, Montgomery CA, Dinowitz M, and Kanagalingam K. Thirteen-week toxicity study of D-alpha-tocopheryl acetate (vitamin E) in Fisher 344 rats. Food Chem Toxicol 24: 1043-1050, 1986.
2. Andres D and Cascales M. Novel mechanism of vitamin E protection against cyclosporine A cytotoxicity in cultured rat hepatocytes. Biochem Pharmacol 64: 267-276, 2002.
3. Apte MV, Haber PS, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, and Wilson JS. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut 44: 534-541, 1999.
4. Apte MV, Phillips PA, Fahmi RG, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, and Wilson J. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 118: 780-794, 2000.
5. Ballantyne CM, Podet EJ, Patsch WP, Harati Y, Appel V, Gotto AM Jr, and Young JB. Effects of cyclosporine therapy on plasma lipoprotein levels. JAMA 262: 53-56, 1989.
6. Brown KE, Poulos JE, Li L, Soweid AM, Ramm GA, O'Neill R, Britton RS, and Bacon BR. Effect of vitamin E supplementation on hepatic fibrogenesis in chronic dietary iron overload. Am J Physiol Gastrointest Liver Physiol 272: G116-G123, 1997.
7. Card JW, Racz WJ, Brien JF, and Massey TE. Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-β1 gene expression but not prevention of mitochondrial dysfunction. J Pharmacol Exp Ther 304: 277-283, 2003.
8. Chow CK, Ibrahim W, Wei Z, and Chan AC. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Radic Biol Med 27: 580-587, 1999.
9. Constantinescu A, Han D, and Packer L. Vitamin E recycling in human erythrocyte membranes. J Biol Chem 268: 10906-10913, 1993.
10. Crompton M, Virji S, Doyle V, Johnson N, and Ward JM. The mitochondrial permeability transition pore. Biochem Soc Symp 66: 167-179, 1999.
11. De Bleser PJ, Xu G, Rombouts K, Rogiers V, and Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274: 33881-33887, 1999.
12. Demols A, Van Laethem JL, Quertinmont E, Degraef C, Delhaye M, Geerts A, and Desviere J. Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 282: G1105-G112, 2002.
13. Elsasser HP, Adler G, and Kern HF. Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat. Pancreas 1: 421-429, 1986.
14. Esposito C, Fornoni A, Cornacchia F, Bellotti N, Fasoli G, Foschi A, Mazzucchelli I, Mazzullo T, Semeraro L, and Dal Canton A. Cyclosporine induces different responses in human epithelial, endothelial and fibroblast cell cultures. Kidney Int 58: 123-130, 2000.
15. Goldkorn T, Balaban N, Shannon M, Chea V, Matsukuma K, Gilchrist D, Wang H, and Chan C. H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J Cell Sci 111: 3209-3220, 1998.
16. Guechot J, Loria A, Serfaty L, Giral P, Giboudeau J, and Poupon R. Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: effect of α-interferon therapy. J Hepatol 22: 22-26, 1995.
17. Gutteridge JM and Halliwell B. The measurement and mechanism of lipid peroxidation in biological systems. Trends Biochem Sci 15: 129-135, 1990.
18. Hoidal JR. Reactive oxygen species and cell signaling. Am J Respir Cell Mol Biol 25: 661-663, 2001.
19. Ibrahim WH, Bhagavan HN, Chopra RK, and Chow CK. Dietary coenzyme Q10 and vitamin E alter the status of these compounds in rat tissues and mitochondria. J Nutr 130: 2343-2348, 2000.
20. Ichimaru N, Takahara S, Kokado Y, Wang JD, Hatori M, Kameoka H, Inoue T, and Okuyama A. Changes in lipid metabolism and effect of simvastatin in renal transplant recipients induced by cyclosporine or tacrolimus. Atherosclerosis 158: 417-423, 2001.
21. Inan C, Kilic I, Kilic K, Kalayci O, and Kotiloglu E. The effect of high dose antenatal vitamin E on hypoxia-induced changes in newborn rats. Pediatr Res 38: 685-689, 1995.
22. Iredale JP, Benyon RC, Pickering J, McCullen M, Northrop M, Pawley S, Hovell C, and Arthur MJ. Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest 102: 538-549, 1998.
23. Israel K, Yu W, Sanders BG, and Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: role of Fas in vitamin E succinate-triggered apoptosis. Nutr Cancer 36: 90-100, 2000.
24. Johnson DW, Saunders HJ, Johnson FJ, Huq SO, Field MJ, and Pollock CA. Fibrogenic effects of cyclosporin A on the tubulointerstitium: role of cytokines and growth factors. Exp Nephrol 7: 470-478, 1999.
25. Johnson DW, Saunders HJ, Johnson FJ, Huq SO, Field MJ, and Pollock CA. Cyclosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: roles of insulin-like growth factor I, transforming growth factor β1, and platelet-derived growth factor. J Pharmacol Exp Ther 289: 535-542, 1999.
26. Kanno T, Utsumi T, Takehara Y, Ide A, Akiyama J, Yoshioka T, Horton AA, Utsumi K. Inhibition of nutrophil-superoxide generation by alpha-tocopherol and coenzyme Q. Free Radic Res 24: 281-286, 1996.
27. Klee CB, Ren H, and Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273: 13367-13370, 1998.
28. Kopp JB and Klotman PE. Cellular and molecular mechanisms of cyclosporin nephrotoxicity. J Am Soc Nephrol 1: 162-179, 1990.
29. Krauskopf A, Buetler TM, Nguyen NS, Mace K, and Ruegg UT. Cyclosporin A-induced free radical generation is not mediated by cytochrome P-450. Br J Pharmacol 135: 977-986, 2002.
30. Kropf J, Schurek JO, Wollner A, and Gressner AM. Immunological measurement of transforming growth factor-beta 1 (TGF-β1) in blood; assay development and comparison. Clin Chem 43: 1965-1974, 1997.
31. Lass A and Sohal RS. Effect of coenzyme Q 10 and α-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J 14: 87-94, 2000.
32. Lawson JA, Rokach J, and FitzGerald GA. Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J Biol Chem 274: 24441-24444, 1999.
33. Lohr M, Fischer B, Weber H, Emmrich J, Nizze H, Liebe S, and Kloppel G. Release of hyaluronan and laminin into pancreatic secretions. Digestion 60: 48-55, 1999.
34. Mansouri A, Demeilliers C, Amsellem S, Pessayre D, and Fromenty B. Acute ethanol administration oxidatively damages and depletes mitochondrial DNA in mouse liver, brain, heart, and skeletal muscles: protective effects of antioxidants. J Pharmacol Exp Ther 298: 737-743, 2001.
35. Mathew P, Wyllie R, Van Lente F, Steffen RM, and Kay MH. Antioxidants in hereditary pancreatitis. Am J Gastroenterol 91: 1558-1562, 1996.
36. Matsumura N, Ochi K, Ichimura M, Mizushima T, Harada H, and Harada M. Study on free radicals and pancreatic fibrosis-pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor. Pancreas 22: 53-57, 2001.
37. Menke A, Yamaguchi H, Gress TM, and Adler G. Extracellular matrix is reduced by inhibition of transforming growth factor beta 1 in pancreatitis in the rat. Gastroenterology 113: 295-303, 1997.
38. Nieto N, Friedman SL, and Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology 35: 62-73, 2002.
39. Oberti F, Valsesia E, Pilette C, Rousselet MC, Bedossa P, Aube C, Gallois Y, Riffiet H, Maiga MY, Penneau-Fontbonne D, and Cales P. Noninvasive diagnosis of hepatic fibrosis or cirrhosis. Gastroenterology 113: 1609-1616, 1997.
40. Packer L, Weber SU, and Rimbach G. Molecular aspects of alphatocotrienol antioxidant action and cell signalling. J Nutr 131: 369S-373S, 2001.
41. Parola M, Muraca R, Dianzani I, Barrera G, Leonarduzzi G, Bendinelli P, Piccoletti R, and Poli G. Vitamin E dietary supplementation inhibits transforming growth factor beta 1 gene expression in the rat liver. FEBS Lett 308: 267-270, 1992.
42. Perez de Lema G, Arribas I, Prieto A, de Arriba G, Rodríguez-Puyal D, and Rodríguez Puyol M. Cyclosporin A-induced hydrogen peroxide synthesis by cultured human mesangial cells is blocked by exogenous antioxidants. Life Sci 62: 1745-1753, 1998.
43. Ricciarelli R, Maroni P, Ozer N, Zingg J, and Azzi A. Age-dependent increase of collagenase expression can be reduced by alpha-tocopherol via protein kinase C inhibition. Free Radic Biol Med 27: 729-737, 1999.
44. Riesle E, Friess H, Zhao L, Wagner M, Uhl W, Baczako K, Korc M, and Buchler MW. Increased expression of transforming growth factor beta after acute oedematous pancreatitis in rats suggests a role in pancreatic repair. Gut 40: 73-79, 1997.
45. 14C-hydroxyproline in collagen and non-collagen proteins. Anal Biochem 57: 1-7, 1974.
46. Rusnak F and Mertz P. Calcineurin: form and function. Physiol Rev 80: 1483-1521, 2000.
47. Salaris SC and Babbs CF. A rapid, widely applicable screen for drugs that suppress free radical formation in ischemia/reperfusion. J Pharmacol Methods 20: 335-345, 1988.
48. Sparmann G, Merkord J, Jaschke A, Nizze H, Jonas L, Lohr M, Liebe S, and Emmrich J. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology 112: 1664-1672, 1997.
49. Studer RK, Craven PA, and DeRubertis FR. Antioxidant inhibition of protein kinase C-signaled increases in transforming growth factor-beta in mesangial cells. Metabolism 46: 918-925, 1997.
50. Thomas SE, Andoh TF, Pichler RH, Shankland SJ, Couser WG, Bennett WM, and Johnson RJ. Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis. Kidney Int 53: 897-908, 1998.
51. Van Dam PS, Bravenboer B, van Asbeck BS, Marx JJ, and Gispen WH. High rat food vitamin E content improves nerve function in streptozotocin-diabetic rats. Eur J Pharmacol 376: 217-222, 1999.
52. Van Laethem JL, Robberecht P, Resibois A, and Deviere J. Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice. Gastroenterology 110: 576-582, 1996.
53. Vaquero V, Molero X, Tian X, Salas A, and Malagelada JR. Myofibroblast proliferation, fibrosis, and defective pancreatic repair induced by cyclosporin in rats. Gut 45: 269-277, 1999.
54. Wallig MA. Xenobiotic metabolism, oxidant stress and chronic pancreatitis. Focus on glutathione. Digestion 59, Suppl 4: 13-24, 1998.
55. Wells RG. Fibrogenesis. V. TGF-β signaling pathways. Am J Physiol Gastrointest Liver Physiol 279: G845-G850, 2000.
56. Wolf A, Trendelenburg CF, Díez-Fernández C, Prieto P, Houy S, Trommer WE, and Cordier A. Cyclosporin A-induced oxidative stress in rat hepatocytes. J Pharmacol Exp Ther 280: 1328-1334, 1997.
57. Yamada T, Sartor RB, Marshall S, Specian RD, and Grisham MB. Mucosal injury and inflammation in a model of chronic granulomatous colitis in rats. Gastroenterology 104: 759-771, 1993.
58. Yu W, Heim K, Qian M, Simmons-Menchaca M, Sanders BG, and Kline K. Evidence for role of transforming growth factor-beta in RRR-alpha-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells. Nutr Cancer 27: 267-278, 1997.
59. Zhang JG, Nicholls-Grzemski FA, Tirmenstein MA, and Fariss MW. Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents. Chem Biol Interact 138: 267-284, 2001.
60. Zingarelli B, Szabó C, and Salzman AL. Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase. Gut 45: 199-209, 1999.