Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats

Journal of Nutritional Biochemistry

Volumn 18, Issue 1, 2007, Pages 64-72

  Xi, Liang ^a   Qian, Zhiyu ^a   Xu, Guanglin ^b   Zheng, Shuguo ^a   Sun, Sai ^a   Wen, Na ^a   Sheng, Liang ^a   Shi, Yun ^a   Zhang, Yabing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING NORMAL UNIVERSITY   (China)

Author keywords

Adiponectin; Adipose tissue; Crocetin; Insulin resistance; Leptin; TNF

Indexed keywords

ADIPONECTIN; CAROTENOID; CROCETIN; FATTY ACID; FRUCTOSE; LEPTIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET; DRUG DOSE COMPARISON; DYSLIPIDEMIA; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; RAT; WHITE ADIPOSE TISSUE;

ADIPOCYTES; ADIPONECTIN; ADIPOSE TISSUE; ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; CAROTENOIDS; CHOLESTEROL, LDL; CROCUS; DIETARY CARBOHYDRATES; ENERGY INTAKE; FRUCTOSE; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; ORGAN SIZE; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS NORVEGICUS;

EID: 34249934672     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2006.03.010     Document Type: Article

References (43)

1. Sampathu S.R., Shivashankar S., and Lewis Y.S. Saffron (Crocus sativus Linne): cultivation, processing, chemistry and standardization. Crit Rev Food Sci Nutr 20 (1984) 123-157
2. Giaccio M. Crocetin from saffron: an active component of an ancient spice. Crit Rev Food Sci Nutr 44 (2004) 155-172
3. Zheng S., Qian Z., Tang F., and Sheng L. Suppression of vascular cell adhesion molecule-1 expression by crocetin contributes to attenuation of atherosclerosis in hypercholesterolemic rabbits. Biochem Pharmacol 70 (2005) 1192-1199
4. Xi L., Qian Z., Shen X., Wen N., and Zhang Y. Crocetin prevents dexamethasone-induced insulin resistance in rats. Planta Med 71 (2005) 917-922
5. Reaven G.M., and Laws A. Insulin resistance, compensatory hyperinsulinemia, and coronary heart disease. Diabetologia 37 (1994) 948-952
6. Thresher J.S., Podolin D.A., Wei Y., Mazzeo R.S., and Pagliassotti M.J. Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance. Am J Physiol Regul Integr Comp Physiol 279 (2000) R1334-R1340
7. Arner P. The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 14 (2003) 137-145
8. Borden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46 (1997) 3-10
9. Bays H., Mandarino L., and DeFronzo R.A. Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89 (2004) 63-478
10. Shimada K., Miyazaki T., and Daida H. Adiponectin and atherosclerotic disease. Clin Chim Acta 344 (2004) 1-12
11. Ruana H., and Lodish H.F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α. Cytokine Growth Factor Rev 14 (2003) 447-455
12. Pittas A.G., Joseph N.A., and Greenberg A.S. Adipocytokines and insulin resistance. J Clin Endocrinol Metab 89 (2004) 447-452
13. Furukawa S., Fujita T., Shimabukuro M., Iwaki M., Yamada Y., Nakajima Y., et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114 (2004) 1752-1761
14. Evans J.L., Youngren J.F., and Goldfine I.D. Effective treatments for insulin resistance: trim the fat and douse the fire. Trends Endocrinol Metab 15 (2004) 425-431
15. Rudich A., Tirosh A., Potashnik R., Hemi R., Kanety H., and Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes 47 (1998) 1562-1569
16. Tsuda T., Ueno Y., Aoki H., Koda T., Horio F., Takahashi N., et al. Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 316 (2004) 149-157
17. Vasdev S., Longerich L., and Gill V. Prevention of fructose-induced hypertension by dietary vitamins. Clin Biochem 37 (2004) 1-9
18. Muller-Wieland D., and Krone W. Disorders of lipid metabolism in insulin resistance. (abstract). Herz 20 (1995) 33-46
19. Lombardo Y.B., and Chicco A.G. Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. J Nutr Biochem 17 (2006) 1-13
20. Rodbell M. Metabolism of isolated fat cells: I. Effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239 (1964) 375-380
21. Elliott S.S., Keim N.L., Stern J.S., Teff K., and Havel P.J. Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76 (2002) 911-922
22. Park J., Lemieux S., Lewis G.F., Kuksis A., and Steiner G. Chronic exogenous insulin and chronic carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in rats. J Lipid Res 38 (1997) 2529-2536
23. Roglans N., Sanguino E., Peris C., Alegret M., Vázquez M., Adzet T., et al. Atorvastatin treatment induced peroxisome proliferator-activated receptor α expression and decreased plasma nonesterified fatty acids and liver triglyceride in fructose-fed rats. J Pharmacol Exp Ther 302 (2002) 232-239
24. Dai S., and McNeill J.H. Fructose-induced hypertension in rats is concentration- and duration-dependent. J Pharmacol Toxicol Methods 33 (1995) 101-107
25. Hotamisligil G.S. Molecular mechanisms of insulin resistance and the role of the adipocyte. Int J Obes Relat Metab Disord 24 (2000) S23-S27
26. Goldstein B.J. Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 90 (2002) 3G-10G
27. Abel E.D., Peroni O., Kim J.K., Kim Y.B., Boss O., Hadro E., et al. Adipose-selective targeting of GLUT4 gene impairs insulin action in muscle and liver. Nature 409 (2001) 729-733
28. Riemens S.C., Sluiter W.J., and Dullaart R.P. Enhanced escape of non-esterified fatty acids from tissue uptake: its role in impaired insulin-induced lowering of total rate of appearance in obesity and type II diabetes mellitus. Diabetologia 43 (2000) 416-426
29. Grundy S.M. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83 (1999) F25-F29
30. Steiner G. Hyperinsulinaemia and hypertriglyceridaemia. J Intern Med 736 Suppl (1994) 23-26
31. Berg A.H., Combs T.P., Du X., Brownlee M., and Scherer P.E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 7 (2001) 947-953
32. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7 (2001) 941-946
33. Kubota N., Terauchi Y., Yamauchi T., Kubota T., Moroi M., Matsui J., et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 227 (2002) 25863-25866
34. Hotamisligil G.S., Shargill N.S., and Spiegelman B.M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259 (1993) 87-91
35. Hotamisligil G.S., Murray D.L., Choy L.N., and Spiegelman B.M. TNF-α inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A 91 (1994) 4854-4858
36. Togashi N., Ura N., Higashiura K., Murakami H., and Shimamoto K. Effect of TNF-α-converting enzyme inhibitor on insulin resistance in fructose-fed rats. Hypertension 39 (2002) 578-580
37. Stennett A.K., and Gainer J.L. TSC for hemorrhagic shock: effects on cytokines and blood pressure. Shock 22 (2004) 569-574
38. Frederich R.C., Hamann A., Anderson S., Loellmann B., Lowell B.B., and Flier J.S. Leptin levels reflect body lipid content in mice: evidence for diet induced resistance to leptin action. Nat Med 1 (1995) 1311-1314
39. Segal K.R., Landt M., and Klein S. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45 (1996) 988-991
40. Juan C.C., Au L.C., Fang V.S., Kang S.F., Ko Y.H., Kuo S.F., et al. Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids. Biochem Biophys Res Commun 289 (2001) 1328-1333
41. Lonnqvist F., Arner P., Nordfors L., and Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1 (1995) 950-953
42. Rentsch J., and Chiesi M. Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett 379 (1996) 55-59
43. Rossi A.S., Lombardo Y.B., Lacorte J.M., Chicco A.G., Rouault C., Slama G., et al. Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. Am J Physiol Regul Integr Comp Physiol 289 (2005) R486-R494