Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 15, 2007, Pages 5316-5321

  Leopoldo, Marcello ^a   Lacivita, Enza ^a   Colabufo, Nicola A ^a   Niso, Mauro ^a   Berardi, Francesco ^a   Perrone, Roberto ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

5 HT1A receptors; 5 HT7 receptors; Arylpiperazine; Bivalent ligands; Structure affinity relationships

Indexed keywords

4 [2 (3 METHOXYPHENYL)ETHYL] 1 (2 METHOXYPHENYL)PIPERAZINE; DIMER; LIGAND; MONOMER; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 7 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; EMBRYO; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; RECEPTOR BINDING; SYNTHESIS;

ANIMALS; CELL LINE; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34249931572     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.010     Document Type: Article

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