Assessing the dynamics of nuclear glucocorticoid-receptor complex: Adding flexibility to gene expression modeling

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 34, Issue 3, 2007, Pages 333-354

  Hazra, Anasuya ^a   DuBois, Debra C ^a   Almon, Richard R ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Glucocorticoid receptor; Glucocorticoids; Methylprednisolone; Nuclear localization; Pharmaco dynamics; Pharmacogenomics

Indexed keywords

BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN BETA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE; TRANSCRIPTION FACTOR; TYROSINE AMINOTRANSFERASE;

ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; GENE EXPRESSION PROFILING; IN VITRO STUDY; LIVER CYTOSOL; MALE; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOGENOMICS; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TRANSPORT; RAT; RETROSPECTIVE STUDY; SINGLE DRUG DOSE;

ACTIVE TRANSPORT, CELL NUCLEUS; ADRENALECTOMY; ANIMALS; CELL NUCLEUS; CYTOSOL; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOCORTICOIDS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; KINETICS; LIVER; MALE; METHYLPREDNISOLONE; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, WISTAR; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER;

EID: 34249876884     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-007-9049-1     Document Type: Article

References (35)

1. Schacke H., Docke W.D., Asadullah K. (2002). Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Therap. 96:23-43
2. Wilcke J.R., Davis L.E. (1982). Review of glucocorticoid pharmacology. Vet. Clin. North Am. - Small Anim. Pract. 12:3-17
3. Belvisi M.G., Wicks S.L., Battram C.H., Bottoms S.E., Redford J.E., Woodman P., Brown T.J., Webber S.E., Foster M.L. (2001). Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity. J. Immunol. 166:1975-1982
4. Maxwell S.R., Moots R.J., Kendall M.J. (1994). Corticosteroids: Do they damage the cardiovascular system?. Postgrad. Med. J. 70:863-870
5. Czock D., Keller F., Rasche F.M., Haussler U. (2005). Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin. Pharmacokinet. 44:61-98
6. Dostert A., Heinzel T. (2004). Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr. Pharm. Des. 10:2807-2816
7. Vamvakopoulos N.O. (1993). Tissue-specific expression of heat shock proteins 70 and 90: Potential implication for differential sensitivity of tissues to glucocorticoids. Mol. Cell Endocrinol. 98:49-54
8. Schoneveld O.J., Gaemers I.C., Lamers W.H. (2004). Mechanisms of glucocorticoid signalling. Biochim. Biophys. Acta 1680:114-128
9. Swartz S.L., Dluhy R.G. (1978). Corticosteroids: Clinical pharmacology and therapeutic use. Drugs 16:238-255
10. Hache R.J., Tse R., Reich T., Savory J.G., Lefebvre Y.A. (1999). Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor. J. Biol. Chem. 274:1432-1439
11. Oakley R.H., Cidlowski J.A. (1993). Homologous down regulation of the glucocorticoid receptor: The molecular machinery. Crit. Rev. Eukaryot. Gene Expr. 3:63-88
12. Sun Y.N., DuBois D.C., Almon R.R., Jusko W.J. (1998). Fourth-generation model for corticosteroid pharmacodynamics: A model for methylprednisolone effects on receptor/gene-mediated glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J. Pharmacokinet. Biopharma. 26:289-317
13. Haughey D.B., Jusko W.J. (1992). Receptor-mediated methylprednisolone pharmacodynamics in rats: Steroid-induced receptor down-regulation. J. Pharmacokinet. Biopharm. 20:333-355
14. Ramakrishnan R., DuBois D.C., Almon R.R., Pyszczynski N.A., Jusko W.J. (2002). Fifth-generation model for corticosteroid pharmacodynamics: Application to steady-state receptor down-regulation and enzyme induction patterns during seven-day continuous infusion of methylprednisolone in rats. J. Pharmacokinet. Pharmacodyn. 29:1-24
15. Jin J.Y., DuBois D.C., Almon R.R., Jusko W.J. (2004). Receptor/gene-mediated pharmacodynamic effects of methylprednisolone on phosphoenolpyruvate carboxykinase regulation in rat liver. J. Pharmacol. Exp. Ther. 309:328-339
16. Sun Y.N., McKay L.I., DuBois D.C., Jusko W.J., Almon R.R. (1999). Pharmacokinetic/pharmacodynamic models for corticosteroid receptor down-regulation and glutamine synthetase induction in rat skeletal muscle by a receptor/gene-mediated mechanism. J. Pharmacol. Exp. Ther. 288:720-728
17. Almon R.R., Dubois D.C., Jin J.Y., Jusko W.J. (2005). Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle. J. Endocrinol. 184:219-232
18. Jin J.Y., Almon R.R., DuBois D.C., Jusko W.J. (2003). Modeling of corticosteroid pharmacogenomics in rat liver using gene microarrays. J. Pharmacol. Exp. Ther. 307:93-109
19. Htun H., Barsony J., Renyi I., Gould D.L., Hager G.L. (1996). Visualization of glucocorticoid receptor translocation and intranuclear organization in living cells with a green fluorescent protein chimera. Proc. Natl. Acad. Sci. USA 93:4845-4850
20. Sun Y.N., DuBois D.C., Almon R.R., Pyszczynski N.A., Jusko W.J. (1998). Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver. J. Pharmacokinet. Biopharm. 26:619-648
21. Ramakrishnan R., DuBois D.C., Almon R.R., Pyszczynski N.A., Jusko W.J. (2002). Pharmacodynamics and pharmacogenomics of methylprednisolone during 7-day infusions in rats. J. Pharmacol. Exp. Therap. 300:245-256
22. Haughey D.B., Jusko W.J. (1988). Analysis of methylprednisolone, methylprednisone and corticosterone for assessment of methylprednisolone disposition in the rat. J. Chromatogr. 430:241-248
23. Boudinot F.D., D'Ambrosio R., Jusko W.J. (1986). Receptor-mediated pharmacodynamics of prednisolone in the rat. J. Pharmacokinet. Biopharm. 14:469-493
24. D'Argenio D.S., Schumitzky A. ADAPT II User's Guide: Pharmacokinetic/ pharmacodynamic Systems Analysis Software, Biomedical Simulations Resource, LA 1997.
25. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275
26. DuBois D.C., Almon R.R., Jusko W.J. (1993). Molar quantification of specific messenger ribonucleic acid expression in northern hybridization using cRNA standards. Anal. Biochem. 210:140-144
27. Ebling W.F., Milsap R.L., Szefler S.J., Jusko W.J. (1986). 6 alpha-Methylprednisolone and 6 alpha-methylprednisone plasma protein binding in humans and rabbits. J. Pharm. Sci. 75:760-763
28. Haughey D.B., Jusko W.J. (1992). Receptor-mediated methylprednisolone pharmacodynamics in rats: Steroid-induced receptor down-regulation. J. Pharmacokinet. Biopharm. 20:333-355
29. Dayneka N.L., Garg V., Jusko W.J. (1993). Comparison of four basic models of indirect pharmacodynamic responses. J. Pharmacokinet. Biopharm. 21:457-478
30. Newton R. (2000). Molecular mechanisms of glucocorticoid action: What is important?. Thorax 55:603-613
31. Falkner K.C., Xiao G.H., Pinaire J.A., Pendleton M.L., Lindahl R., Prough R.A. (1999). The negative regulation of the rat aldehyde dehydrogenase 3 gene by glucocorticoids: Involvement of a single imperfect palindromic glucocorticoid responsive element. Mol. Pharmacol. 55:649-657
32. Lindahl R., Xiao G.H., Falkner K.C., Prough R.A. (1999). Negative regulation of rat hepatic aldehyde dehydrogenase 3 by glucocorticoids. Adv. Exp. Med. Biol. 463: 159-164
33. Hager G.L., Smith C.L., Fragoso G., Wolford R., Walker D., Barsony J., Htun H. (1998). Intranuclear trafficking and gene targeting by members of the steroid/nuclear receptor superfamily. J. Steroid Biochem. Mol. Biol. 65:125-132
34. Sackey F.N., Hache R.J., Reich T., Kwast-Welfeld J., Lefebvre Y.A. (1996). Determinants of subcellular distribution of the glucocorticoid receptor. Mol. Endocrinol. 10:1191-1205
35. Haughey D.B., Jusko W.J. (1992). Bioavailability and nonlinear disposition of methylprednisolone and methylprednisone in the rat. J. Pharm. Sci. 81:117-121